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X-WR-CALDESC:Events for Department of Medicine
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DTSTART;TZID=America/New_York:20180109T140000
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DTSTAMP:20260622T110615
CREATED:20180109T190000Z
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SUMMARY:McAllister Heart Institute Seminar Series: Nenad Bursac\, PhD\, “Engineering Excitable Tissues for Experimental Studies and Regenerative Therapy”
DESCRIPTION:Speaker: Nenad Bursac\, PhD\, Professor of Biomedical Engineering\, Duke UniversityTopic: Engineering Excitable Tissues for Experimental Studies and Regenerative Therapy \nPresentation Preview: In this talk\, I will present our recent progress on engineering of human excitable tissues using primary\, stem cell-derived\, and genetically engineered cell sources. I will first describe scalable methodology for engineering of functional human cardiac tissues for use in medium-throughput in vitro studies and treatment of cardiac injury. Then I will describe how building on our work with rat cells\, we for the first time engineered electrically and chemically responsive\, contractile human skeletal muscle tissues made of primary cells isolated from standard muscle biopsies and induced pluripotent stem cells. Finally\, I will describe methods to convert human unexcitable fibroblasts into an autonomous source of electrically excitable and actively conducting cells using forced expression of prokaryotic and mammalian ion channels. Together\, these results open doors to new studies of human excitable tissue function\, disease\, and regeneration\, and provide preclinical assays for testing of novel therapeutics.
URL:https://www.med.unc.edu/medicine/event/copy3_of_mcallister-heart-institute-seminar-series-hossein-ardehali-md-phd-role-of-iron-in-cardiovascular-disease/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20180111T120000
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SUMMARY:Medicine Grand Rounds\, Balfour Sartor and Edward Barnes\, "Post-Operative Crohn’s Disease: Current and Future Management"
DESCRIPTION:Rescheduled from January 4 — In this lecture\, Drs. Sartor and Barnes will summarize an evidence-based approach to the management of post-operative Crohn’s disease\, and describe the future landscape based on novel molecular and microbial predictors of risk of recurrence. This topic is clinically important because the majority of patients with Crohn’s disease eventually undergo surgical resection for refractory disease or complications (obstruction or abscess/fistulae)\, and experience recurrent disease after resection. There are important advances in the field\, but the goal of preventing recurrence after surgery has not yet been achieved; this goal will require innovative approaches. \nBalfour Sartor is a gastroenterologist and mucosal immunologist with a long-standing interest in mechanisms by which commensal microbiota induce chronic intestinal inflammation vs. mucosal homeostasis. He specializes in inflammatory bowel diseases (IBD) and co-directs the UNC Multidisciplinary IBD Center. \nEdward Barnes is assistant professor of Medicine in the Division of Gastroenterology and Hepatology. Dr. Barnes’ interests include evaluation of clinical outcomes related to differing treatment strategies among patients with Inflammatory Bowel Disease\, as well as the effects that these strategies have on cost and resource utilization.
URL:https://www.med.unc.edu/medicine/event/jan-11/
CATEGORIES:Medicine Grand Rounds
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