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SUMMARY:McAllister Heart Institute Seminar Series: Deepak Voora\, MD\, “Genotype-informed Statin Therapy”
DESCRIPTION:Speaker: Dr. Deepak Voora\, MD\, Associate Professor of Medicine\, Department of Cardiology\, Center for Applied Genomics and Precision Medicine at Duke University Topic: “Genotype-informed Statin Therapy” \nSeminar Synopsis: Statins are among the most commonly prescribed medications to lower cholesterol and to prevent cardiovascular disease. Although well tolerated by most patients\, a significant proportion of patients develop musculoskeletal symptoms associated with statin therapy that can lead to premature statin discontinuation\, elevated cholesterol\, and increased risk for cardiovascular events. Our group was among the first to discover a reduced function genetic variant in the SLCO1B1 gene that predisposes to higher statin concentrations and statin-associated musculoskeletal symptoms (SAMS). We have extended this finding to higher cholesterol levels in patients with cardiovascular disease treated with statins and tested for effects on cardiovascular events. The statin-specific nature of SLCO1B1 associations with SAMS that we and others have identified laid the foundation to translate our findings into the clinic. We have developed a genotype-informed statin therapy (GIST) intervention based on communicating SLCO1B1 genotype based risk for SAMS and tailored prescriptions to reduce the risk of SAMS. In two prospective studies\, including a randomized clinical trial\, GIST improves perceptions of statin therapy\, increased statin re-initiation\, and lowered cholesterol levels in patients with statin-intolerance.
URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-dr-deepak-voora-md-201cgenotype-informed-statin-therapy201d/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20180222T120000
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SUMMARY:Medicine Grand Rounds\, Nancy Allbritton "Organs-on-Chips"
DESCRIPTION:Organ-on-chips are miniaturized devices that arrange living cells to simulate functional subunits of tissues and organs. These microdevices provide exquisite control of tissue microenviroment for the investigation of organ-level physiology and disease. Human organ-on-chips are expected to transform biomedical research providing platforms that accurately replicate human tissues\, enable a better understanding of human-to-human physiologic variations and even permit patient-specific organ mimics. These human organ facsimiles will fundamentally alter drug discovery and development by providing human constructs for screening assays\, toxicity measurements and investigation of molecular-level drug actions. \nNancy L. Allbritton is the Kenan Professor and Chair of the Joint Department of Biomedical Engineering at UNC and NC State\, and Kenan Professor in the UNC Department of Chemistry.  Her research focuses on the development of novel technologies for applications in single-cell analysis\, micro-arrays and fluidics\, and organ-on-chip. It has resulted in over 180 full-length journal publications and patents and led to 15 commercial products. Her research program has been well funded by the National Institutes of Health with nearly $60 million in grants since 1994.
URL:https://www.med.unc.edu/medicine/event/feb-22/
CATEGORIES:Medicine Grand Rounds
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