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DTSTART;TZID=America/New_York:20180319T120000
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SUMMARY:Cardiovascular Grand Rounds: Dr. Joshua Vega\, “UNC Project Health for Leon: A Joint Mission for Global Health”
DESCRIPTION:Speaker: Joshua Vega\, UNC Cardiology FellowTopic: “UNC Project Health for Leon: A Joint Mission for Global Health”
URL:https://www.med.unc.edu/medicine/event/cardiovascular-grand-rounds-dr-joshua-vega/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20180320T140000
DTEND;TZID=America/New_York:20180320T150000
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SUMMARY:McAllister Heart Institute Seminar Series: James F. Martin\, MD\, PhD\, “Hippo Signaling in Heart Regeneration”
DESCRIPTION:Speaker: Joan Taylor\, PhD\, Professor and Vice Chair for Research in Pathology and Lab Medicine\, UNC School of MedicineTopic: “GRAFs mind the GAP between muscle fate and function” \nSeminar Synopsis: The overall goal of our research is to characterize the intracellular signaling pathways that govern normal and aberrant growth responses in the cardiovascular and musculoskeletal system.  For this seminar\, I will focus on the role of GRAF family member RhoGAPs in muscle fate and function.  We originally identified GRAF1 (GTPase-regulator for RhoA associated with FAK) in an un-biased screen for Focal Adhesion Kinase binding partners and over the past several years we have shown that GRAF1 (Arhgap26) and it’s family members GRAF2 (Arhgap10) and -3 (Arhgap42) are critical for limiting RhoA activity in muscle (cardiac\, skeletal and smooth) wherein they play unique roles in co-regulating actin and membrane dynamics. In this seminar\, I will highlight our latest studies on GRAF3 which indicate a critical role for this protein in the development and pathogenesis of human hypertension. Moreover\, I will present new evidence to suggest that GRAF1 and GRAF2 may be equally as important for maintaining cardiac and skeletal muscle homeostasis respectively by novel mechanisms that involve mitochondrial quality control. Collectively\, our findings support the possibility that targeting GRAFs might provide promising therapeutic strategies to limit hypertension and striated muscle degeneration.
URL:https://www.med.unc.edu/medicine/event/mcallister-heart-institute-seminar-series-james-f-martin-md-phd-201chippo-signaling-in-heart-regeneration201d/
CATEGORIES:Medicine Grand Rounds
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DTSTART;TZID=America/New_York:20180322T000000
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CREATED:20180322T040000Z
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SUMMARY:Medicine Grand Rounds\, Edwin Kim "Drug Allergies Affecting the Care of Inpatients"
DESCRIPTION:Drug allergies–in particular allergy to beta-lactam antibiotics–affects as many as 15% of all hospitalized patients. There is a growing pool of data demonstrating the significant effect a drug allergy diagnosis can have on morbidity and mortality of the hospitalized patient\, as well as the immense cost it can add to the health care system. A simple skin-based testing procedure has been commercially available since 2009; data on its use has shown that the vast majority of penicillin-allergic patients are no longer allergic at the time of testing. However\, far too few patients receive this testing. Dr. Kim will review data showing the scope of the drug allergy problem. This will include the diagnostic and therapeutic options for these patients\, with a focus on the pilot UNC allergy and immunology inpatient penicillin allergy testing program. \nEdwin Kim is specifically interested in the use of immunotherapy in the treatment of food allergy. He is the director of the UNC Allergy and Immunology Fellowship Training Program as well as of the UNC Food Allergy Initiative.
URL:https://www.med.unc.edu/medicine/event/mar-22/
CATEGORIES:Medicine Grand Rounds
ATTACH;FMTTYPE=image/jpeg:https://www.med.unc.edu/medicine/wp-content/uploads/sites/945/2018/12/edwin-kim.jpeg
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