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Project: Deprescribing Bisphosphonates in Older Nursing Home Residents with Dementia

Grant Number: U.S. Deprescribing Network Pilot (NIA 1R24AG064025)

The goal of this study was to develop operational definitions for examining deprescribing of bisphosphonates using Medicare Part D prescription drug event data. In subsequent analyses, the study also examined the incidence and predictors of deprescribing bisphosphonates in a sample of Medicare nursing home residents with dementia. This work served as the foundation for subsequent research to examine clinical outcomes and cost-effectiveness of bisphosphonate deprescribing versus continued use in older nursing home residents with dementia.


Principal Investigator




Niznik JD, Aspinall SL, Hanson LC, Gilliam MA, Li XT, Kelley CJ, Thorpe CT. Patterns of oral bisphosphonate deprescribing in older nursing home residents with dementia. Osteoporos Int. 2022 Feb;33(2):379-390. doi: 10.1007/s00198-021-06141-9. Epub 2021 Sep 4.