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Assistant Professor

Areas of Interest

Mechanisms of pancreatic cancer-associated venous thrombosis

About

My research interest focuses on the mechanisms of cancer-associated thrombosis and bleeding. My primary interest is mechanisms of pancreatic cancer-associated venous thrombosis because pancreatic cancer has one of the highest rates of venous thrombosis. I have found that tumor-derived tissue factor positive extracellular vesicles, neutrophils and neutrophil extracellular traps, and plasminogen activator inhibitor-1 independently contribute to venous thrombosis in mouse models of pancreatic cancer. Another interest is the mechanisms of acute leukemia-associated disseminating intravascular coagulation. I am currently investigating the levels of different biomarkers that reflect activation of coagulation and fibrinolysis, as well as fibrinolysis inhibitors in plasma samples from patients with different types of acute leukemia. I am also developing mouse models of acute leukemia to study the roles of host cells versus leukemia cells and different coagulation and fibrinolysis proteins and their inhibitors in acute leukemia-associated disseminated intravascular coagulation.

Education and Training

  • Undergraduate Tokyo University of Science
  • PhDThe University of Tokyo
  • Fellowship National Cancer Center Hospital East Japan
  • Address

    116 Manning Drive

    8004 Mary Ellen Jones Building

    Campus Box 7035

    Chapel Hill, NC 27599