Here is a summary of the careers of each of the members along with information about their current research and research interests.
Dr. Erica Sparkenbaugh, PhD
After graduating with a BS in Biology from Allegheny College in Meadville, PA, I pursued a PhD in Pharmacology and Toxicology at Michigan State University in the lab of Bob Roth. I investigated mechanisms of drug-induced liver injury, and developed an interest in the crosstalk of coagulation and inflammation. I joined the Pawlinski lab as a post-doctoral fellow in 2012 to investigate these pathways in mouse models of sickle cell disease and heart failure. Since that time, I have developed a deep interest in examining the mechanisms of thrombin generation and end-organ failure in sickle cell disease. I have two major ongoing projects in the laboratory. (1) Investigate the mechanism of thrombin generation in sickle cell disease during steady state and vaso-occlusive crisis and (2) Determine the best anti-coagulant treatment strategy to reduce thrombotic complications and end-organ damage in sickle cell disease.
January 2012 – Joined the Pawlinski Lab
December 2012 – Received Outstanding Abstract Award and presented at the ASH meeting in Atlanta
June 2013 – Received F32 Individual Postdoctoral Fellowship to investigate the role of PAR-2 in pulmonary hypertension of sickle cell disease
July 2013 – Presented at the ISTH World Congress in Amsterdam
May 2014 – Presented at the AHA ATVB Meeting in Toronto
June 2015 – Presented at the ISTH World Congress in Toronto
June 2016 – Received an American Heart Association (AHA) Postdoctoral Fellowship to evaluate the role of the extrinsic coagulation cascade in end-organ failure of sickle cell disease
Dr. Shaobin Wang, PhD
I received my PhD degree in Physiology at University of Oklahoma Health Science Center. I joined the Pawlinski lab as a post-doctoral fellow in 2013 to investigate coagulation factors especially tissue factor (TF) in mouse models of cerebral stroke and multiple sclerosis. I have two major ongoing projects in the laboratory. (1) Investigate the mechanisms of tissue factor and proteinase-activated receptors in multiple sclerosis in a mouse EAE mole (2) Determine the function of tissue factor in ischemia stroke and hemorrhagic stroke.