Areas of Interest
HIV latency, Epigenetic regulation of HIV, HIV tissue reservoirs, HIV cure strategies
My lab is interested in the epigenetic regulation of HIV transcription and latency. We recently discovered that a previously unrecognized epigenetic modification called histone crotonylation is involved in an efficient transcription of HIV. The induction of crotonylation disrupted HIV latency. In combination with other latency reversal agents (LRAs), the disruption of HIV latency is highly achieved compared with single LRA. We are trying to understand how crotonylation of histone and non-histone proteins regulated signaling pathways directly modulate HIV transcription and latency. These discoveries may lead to new tools to fight for the latent HIV infection. We are also interested in how cells in tissues are infected by HIV, such as CNS. For example, how the unique interaction among HIV, immune cells, vascular cells, and neuron cells contributes to the initial seeding of the latent reservoirs in the CNS, and whether we can target the unique viral infection and latency signaling pathways to attack HIV reservoirs in the CNS, thereby controlling HIV infection and HIV-associated neurocognitive disorders (HAND).
Education and Training
- Undergraduate Anhui University
- Medical School Academy of Military Medical Sciences
- Fellowship University of North Carolina at Chapel Hill
- Fellowship Vanderbilt University