{"id":2610,"date":"2026-04-06T13:44:46","date_gmt":"2026-04-06T17:44:46","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/?p=2610"},"modified":"2026-04-23T13:48:31","modified_gmt":"2026-04-23T17:48:31","slug":"dissertation-work-published-in-the-journal-of-immunology","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/2026\/04\/dissertation-work-published-in-the-journal-of-immunology\/","title":{"rendered":"Dissertation Work Published in The Journal of Immunology"},"content":{"rendered":"<div>We are thrilled to share that Dr. Morgan McCullough\u2019s dissertation research has been published in <em>The Journal of Immunology<\/em>.<\/div>\n<div><\/div>\n<div><\/div>\n<div>\n<p><em>CNS1-Dependent Regulatory T Cells Shape Recovery from Acute Lung Injury<\/em><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p><strong>ABSTRACT<\/strong><\/p>\n<p>Regulatory T cells (Tregs) play a crucial role in mediating recovery from acute lung injury (ALI). However, the complex roles of functionally heterogeneous Treg subsets in the lung during the resolution of acute inflammation remain unclear. To investigate the role of peripherally induced Tregs, we utilized mice lacking conserved noncoding sequence 1 (CNS1) of the <em>Foxp3<\/em> locus, a genetic deletion that impairs peripheral Treg induction. We found that CNS1-deficient mice exhibit greater mortality and delayed resolution during ALI. Tregs induced via CNS1 modulated antiviral and pro-inflammatory immune responses in the lung during influenza. Mechanistically, single-cell RNA sequencing reveals that CNS1-deficient Tregs fail to fully engage the Treg transcriptional program that supports optimal suppressive and reparative function in the lung. Our findings highlight a critical role for CNS1-dependent peripherally induced Tregs in determining ALI severity, providing insight into how distinct Treg subpopulations may be therapeutically harnessed to mitigate tissue damage during respiratory disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are thrilled to share that Dr. Morgan McCullough\u2019s dissertation research has been published in The Journal of Immunology. CNS1-Dependent Regulatory T Cells Shape Recovery from Acute Lung Injury &nbsp; ABSTRACT Regulatory T cells (Tregs) play a crucial role in mediating recovery from acute lung injury (ALI). However, the complex roles of functionally heterogeneous Treg &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/mocklab\/2026\/04\/dissertation-work-published-in-the-journal-of-immunology\/\" aria-label=\"Read more about Dissertation Work Published in The Journal of Immunology\">Read more<\/a><\/p>\n","protected":false},"author":35778,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-2610","post","type-post","status-publish","format-standard","hentry","category-uncategorized","odd"],"acf":[],"featured_image":false,"featured_image_medium":false,"featured_image_medium_large":false,"featured_image_large":false,"featured_image_thumbnail":false,"featured_image_alt":false,"category_details":[{"name":"Uncategorized","link":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/category\/uncategorized\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/posts\/2610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/users\/35778"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/comments?post=2610"}],"version-history":[{"count":2,"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/posts\/2610\/revisions"}],"predecessor-version":[{"id":2612,"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/posts\/2610\/revisions\/2612"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/media?parent=2610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/categories?post=2610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/mocklab\/wp-json\/wp\/v2\/tags?post=2610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}