UNC Center for Bronchiectasis Care Team
While there are many pulmonary experts at UNC capable and experienced in the management of virtually all lung diseases, there are a few clinicians particularly interested and experienced in managing Bronchiectasis and NTM / mycobacterial lung infections.
Peadar G. Noone, MD DCH FCCP FRCPI
Professor of Medicine
Dr. Noone is the Medical Director of the UNC Center for Bronchiectasis Care. He graduated from the University College Galway, Ireland in 1983, and trained in internal medicine and diseases of the lung in Ireland, Boston MA, and in Chapel Hill. He has over twenty years of experience in the diagnosis and management of bronchiectasis and Mycobacterial Lung Infections, having done an advanced clinical and research fellowship at UNC under the mentorship of Michael Knowles, a world expert in the field, focusing on unusual forms of bronchiectasis, including adult-diagnosed cystic fibrosis, Primary Ciliary Dyskinesia (PCD), and idiopathic bronchiectasis. He has extensive experience in seeing adult patients of all age spectrums, from around not just North Carolina, but from around the USA and Canada, with occasional referrals from around the world (Brazil, the UK, Ireland, the Middle East). He has managed patients with highly complex forms of bronchiectasis and infections over the years. He has participated in NIH and industry funded research addressing the evaluation, diagnosis, management, and development of novel treatments for bronchiectasis and NTM. From 2004-5 he was co-director of the CF Center in Belfast Northern Ireland, which also has one of the largest bronchiectasis clinics in the UK outside of London. From 2005-2015 he was medical director of the UNC Lung Transplant Program, which involved significant experience in the diagnosis and management of infectious complications in the lung in people with depressed immune systems, including mycobacterial lung infections. He has numerous publications in the field, a sampling of which is below, and has lectured widely around the world. He communicates regularly with bronchiectasis and NTM experts around the US, Canada, the UK, Europe, New Zealand and Australia, and is an active member of the Bronchiectasis Research Registry. In addition to the above specialty interests, he is a keen teacher of medical students and is involved in curricular design and delivery at the School of Medicine.
Mary Leigh Anne (“Leigh Anne”) Daniels, MD, MPH
Clinical Instructor of Medicine
Dr. Daniels is the co-Director of the UNC Center for Bronchiectasis Care. She gained her MD from Rutgers New Jersey Medical School in NJ in 2006, including an MPH in Biostatistics & Epidemiology. She trained in internal medicine and pediatrics in Rochester, NY, followed by a fellowship in diseases of the lung at the University of North Carolina, Chapel Hill, NC. Since her appointment to the faculty at UNC, she focuses on the diagnosis and management of patients with all causes of bronchiectasis, including cystic fibrosis and primary ciliary dyskinesia (PCD). Extending from her clinical experience with these patients, her research particularly focuses on discovering the genetic variations that contribute to the development of idiopathic bronchiectasis (bronchiectasis without a known cause). These people are frequently infected with non-tuberculous mycobacterium (NTM), and many have family members with bronchiectasis. She is part of the research endeavors of the national Genetic Disorders of Mucociliary Clearance Consortium, the PCD Foundation and the Bronchiectasis Research Registry. She is a co-investigator for several clinical trials for PCD and idiopathic bronchiectasis. Recently, she gave the prestigious “Grand Rounds” lecture at the UNC School of Medicine on the State of the Art, diagnosis and management of NTM. She enjoys working with patients of all ages to improve their quality of life with bronchiectasis through optimal management of their lung disease.
Michael R. Knowles, MD
Professor of Medicine
Dr. Michael R Knowles is a Professor of Medicine at UNC, having gained his MD at UNC (1971), and his internal medicine training at Duke University (1975) and training in diseases of the lung at UNC Chapel Hill (1980). He is a recognized world expert in the area of CF, PCD, bronchiectasis, among other things (one of very few with such expertise). He has over four decades of clinical and research experience that spans the disciplines of biology, physiology, and design of clinical trials seeking new therapies for these diseases, ultimately to ease the suffering, and to improve quality of life and survival in affected individuals. He is currently the head of two large multicenter studies: 1) Genetic Modifiers of Disease phenotype (severity) in cystic fibrosis lung and liver disease, which also includes a recently formed International Consortium doing a whole genome scan; and 2) a Consortium with several sites in North America to study rare genetic disorders of mucociliary clearance. He is and has been holder of several large research grants to study many aspects of the diseases above, for example, that of a genetic modifiers of disease phenotype (severity) in CF lung and liver disease, which also includes differential gene expression studies and an international consortium doing a whole genome scan.
RT Clinical Specialist
Jodie Jones is the Bronchiectasis Clinical Specialist for Respiratory Care. Jodie is originally from Michigan and relocated to the area in 2012 to join the UNC Healthcare team and to enjoy the warmer climate. Jodie has a diverse clinical background. She has worked in a community hospital setting, the durable medical equipment industry, and at multiple large teaching hospitals. Jodie has enjoyed caring for people of all age groups. Jodie is passionate about collaborating with the team to provide comprehensive patient care with a special emphasis on airway clearance techniques, breathing / cough maneuvers, devices and inhaled medicines.
Adam Kimple, MD
Dr. Kimple is an assistant professor in the Department of Otolaryngology/Head & Neck Surgery. He completed his MD/PhD at UNC – Chapel Hill in 2012. Following this, he continued his training at UNC and completed a residency in Otolaryngology and a fellowship in Advanced Rhinology, Allergy and Endoscopic Skull Base Surgery. His clinical and research interests are centered around treating patient with chronic rhinosinusitis and mucociliary disorders such as cystic fibrosis and primary ciliary dyskinesia. He enjoys working with patients of all ages to improve their quality of life through optimal management of their sinus disease.
Gita Mody, MD, MPH
Assistant Professor of Surgery
Dr. Gita Mody joined the UNC Department of Surgery, Division of Cardiothoracic Surgery in 2018. She completed her MD at Washington University School of Medicine in 2007 and then trained in general surgery and cardiothoracic surgery at Brigham and Women’s Hospital. She also completed a research fellowship in Global Health Equity at the BWH Center for Surgery and Public Health as well as MPH in Clinical Effectiveness from the Harvard School of Public Health in 2012. Her research projects are on improving surgical outcomes including patient-centered outcomes after thoracic surgery. She works closely with Socios En Salud (Partners In Health) in Peru to improve care for patients with tuberculosis and other pulmonary infections.
Kunal Patel, MD PhD
Assistant Professor of Medicine
Dr. Patel recently joined the UNC Center for Bronchiectasis care in the fall of 2018. He completed an MD PhD program at the University of Pennsylvania with a focus on virology. He trained in internal medicine at Brigham and Women’s Hospital in Boston, MA before returning to Philadelphia for a fellowship in pulmonary and critical care medicine at the University of Pennsylvania. His research in fellowship focused on T cell immunology in influenza and has an interest in lung immunology and deficits that may predispose patients to developing chronic lung infections such as non-tuberculosis mycobacteria. His clinical practice also includes patients with interstitial lung disease and fibrosis as well as critical care medicine. He is very interested in medical education with a focus on teaching patient centered care.
Emily is a clinical pharmacist that works primarily with UNC adult Cystic Fibrosis and PCD/bronchiectasis patients cared for by the UNC Adult Cystic Fibrosis Center and UNC Bronchiectasis and NTM Center.
Emily earned her Doctor of Pharmacy degree in 2008 from UNC Eshelman School of Pharmacy and subsequently completed a general practice pharmacy residency in 2009 at the Durham VA Medical Center. Emily has been at UNC Health Care since 2015, first as an inpatient clinical pharmacist, and then transitioned to her role in the outpatient pulmonary clinic in 2016, where she has been a fabulous addition to the team, given the complexity of the medicines involved in treating patients with these diseases. Thus, Emily’s area of interest include transitions of care, management of non-tuberculous mycobacterium (NTM), and cystic fibrosis, helping manages manage patients on home IV antibiotics, does patient education, and works closely with the team on the treatment and monitoring plans for patients.
Infectious diseases – Claire Farel, MD, MPH
Radiology – Various expert radiologists
Cardiothoracic Surgery – Ben Haithcock, MD and Jason Long, MD, MPH
Otolaryngology/Head and Neck Surgery – Brent Senior, MD, Charles Ebert MD, MPH, Adam Zanation, MD, and Brian Thorp, MD
Microbiology and Immunology & Pathology and Laboratory Medicine – Peter Gilligan, PhD
UNC Contributions to the Field and Relevant Publications
- Mary LeighAnne Daniels, Kelli Sullivan, Jennifer Dane, Sanniya Nanda, Michael R Knowles and Peadar G Noone. Presented at the World Bronchiectasis Meeting, Milan Italy July 2017: Creating a new Center for Bronchiectasis and NTM Care at an academic center in the USA. The UNC Center for Bronchiectasis / NTM Care, Division of Pulmonary and Critical Care Medicine; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
- Noone PG, Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zariwala MA, Knowles MR. Primary Ciliary Dyskinesia: Diagnostic and Phenotypic Features. AmJRespirCrit Care Med 2004; 169: 459-467.
- Adjemian J, Olivier KN, Seitz AE, Holland SM, Prevots DR. Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med 2012; 185: 881-886.
- Strollo SE, Adjemian J, Adjemian MK, Prevots DR. The Burden of Pulmonary Nontuberculous Mycobacterial Disease in the United States. Annals of the American Thoracic Society 2015.
- Lobo LJ, Zariwala MA, Noone PG. Primary ciliary dyskinesia. QJM : monthly journal of the Association of Physicians 2014; 107: 691-699.
- McShane PJ, Naureckas ET, Tino G, Strek ME. Non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2013; 188: 647-656.
- Noone PG, Knowles MR. ‘CFTR-opathies’: disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations. Respir Res 2001; 2: 328-332.
- Daniels MLA, Leigh MW, Davis SD, Armstrong MC, Carson JL, Hazucha M, Dell SD, Eriksson M, Collins FS, Zariwala MA. Founder mutation in RSPH4A identified in patients of Hispanic descent with Primary Ciliary Dyskinesia. Hum Mutat. 34:1352-1356, 2013.
- Knowles MR, Daniels LA, Davis SD, Zariwala MA, Leigh MW. Primary ciliary dyskinesia: Recent advances in diagnostics, genetics, and characterization of clinical disease. Am J Respir Crit Care Med. 188(8):913-922, 2013.
- Daniels MLA & Noone PG. Genetics, diagnosis and future treatment strategies for primary ciliary dyskinesia. Expert Opinion on Orphan Drugs. 3(1):31-44, 2015.
- Jason Lobo, Maimoona A Zariwala and Peadar G Noone. Primary Ciliary Dyskinesia. Semin Respir Crit Care Med. 2015 Apr;36(2):169-79.
- US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary. Floto RA, Olivier KN, Saiman L, Daley CL, Herrmann JL, Nick JA, Noone PG, Bilton D, Corris P, Gibson RL, Hempstead SE, Koetz K, Sabadosa KA, Sermet-Gaudelus I, Smyth AR, van Ingen J, Wallace RJ, Winthrop KL, Marshall BC, Haworth CS. Thorax. 2016 Jan;71(1):88-90