{"id":34487,"date":"2019-06-21T14:52:01","date_gmt":"2019-06-21T18:52:01","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=34487"},"modified":"2023-06-06T17:34:14","modified_gmt":"2023-06-06T21:34:14","slug":"new-research-from-qian-lab-mcallister-heart-institute","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/new-research-from-qian-lab-mcallister-heart-institute\/","title":{"rendered":"New Research from Qian Lab, McAllister Heart Institute"},"content":{"rendered":"<p><a href=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/Qian-release.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-884 size-medium\" src=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/Qian-release-226x300.jpg\" alt=\"Li Qian, Ph.D.\" width=\"226\" height=\"300\" \/><\/a>A McAllister team from Li Qian\u2019s Lab has published new research in <em><a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(19)30224-3\" target=\"_blank\" rel=\"noopener noreferrer\">Cell Stem Cell<\/a><\/em> that holds promise to \u201cmend a broken heart\u201d by describing how to directly reprogram human fibroblasts into cardiomyocytes.\u00a0 The research described in the paper, \u201cSingle Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming\u201d, is the first to develop a stable, reproducible, minimalistic platform for this reprogramming. Moreover, by taking advantage of the latest single-cell technologies and mathematical modeling, Li Qian, PhD, and her group have produced a high-resolution molecular roadmap to guide precise and efficient reprogramming.<\/p>\n<p>&nbsp;<\/p>\n<p>The work is a crucial advance because fibroblasts form scar tissue that leads to permanent loss of heart function after a heart attack, while cardiomyocytes form the heart muscle that pumps blood throughout the body. A long term therapeutic goal is to be able to quickly reprogram fibroblasts in human patients with myocardial infarction so that new heart muscle forms to recover heart function. Victoria Bautch, PhD, Co-Director of MHI and Chapin Distinguished Professor of Biology, says that \u201cIt is intriguing and important that the process of reprogramming human fibroblasts differs in significant ways from murine reprogramming, as shown in the new work from the Qian lab. Qian and her team\u2019s cutting-edge research embodies the mission of McAllister Heart Institute to integrate basic cardiovascular scientific discoveries with translational and clinical outcomes to improve human health.\u201d<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/yang-zhou.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-887\" src=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/yang-zhou-200x300.jpg\" alt=\"Yang Zhou, Ph.D.\" width=\"200\" height=\"300\" \/><\/a> <a href=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/Ben-Keepers.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-886\" src=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/Ben-Keepers-200x300.jpg\" alt=\"Ben Keepers, Ph.D.\" width=\"200\" height=\"300\" \/><\/a>The supportive, team-oriented research environment at McAllister fosters such innovative research and helps support the next generation of young scientists. Qian is Associate Director of MHI and Associate Professor of Pathology and Laboratory Animal Medicine, and has made numerous seminal discoveries since setting up her independent research program in MHI 7 years ago. The paper\u2019s first author, <a href=\"https:\/\/www.uab.edu\/engineering\/bme\/people\/faculty\/yang-zhou\" target=\"_blank\" rel=\"noopener noreferrer\">Yang Zhou, PhD<\/a>, started this year as Assistant Professor at the University of Alabama at Birmingham. Another co-author, Ben Keepers, initially worked on the project during a rotation at Qian Lab 3 years ago. His enjoyable and productive work led him to join Qian Lab long-term, where he is now working on the next step&#8211; generating a &#8220;foot-print free&#8221; approach using CRISPRi system rather than viral delivery of GMT133 for human cardiac reprogramming. Ben is currently a trainee in MHI\u2019s <a href=\"https:\/\/www.med.unc.edu\/ivb\/\" target=\"_blank\" rel=\"noopener noreferrer\">Integrative Vascular Biology Training Program<\/a>, an NIH-funded initiative that exposes students to the latest concepts in cardiovascular biology in collaboration with faculty from 12 UNC departments.<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/MHI-Logo.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-903\" src=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/MHI-Logo-300x80.png\" alt=\"MHI Logo\" width=\"300\" height=\"80\" \/><\/a>McAllister creates an environment where researchers can thrive in obtaining key funding to support their work. The <em>Cell Stem Cell<\/em> research was supported by National Institutes of Health, National Heart, Lung, and Blood Institute, the American Heart Association, a Jefferson Pilot Award, as well as internal UNC funds and generous gifts from Dr. Hugh \u201cChip\u201d McAllister and Cecil Sewell. MHI faculty and trainees have successfully acquired outside funding from the NIH, the American Heart Association, the National Science Foundation (NSF), and the Dept. of Defense, that totals almost $7M for 2019.<\/p>\n<p>McAllister Heart Institute is a center for innovation in cardiovascular research. The vibrant, multidisciplinary environment at MHI supports faculty, postdocs, and other trainees to perform cutting-edge research and help translate these innovative discoveries into clinical practice.<\/p>\n<p>Learn more about <a href=\"http:\/\/uncliqian.web.unc.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\">Qian Lab<\/a>\u2019s research described in <em>Cell Stem Cell<\/em>&#8230;<a href=\"http:\/\/news.unchealthcare.org\/news\/2019\/june\/scientists-make-single-cell-map-to-reprogram-scar-tissue-into-healthy-heart-cells\" target=\"_blank\" rel=\"noopener noreferrer\">Learn More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A McAllister team from Li Qian\u2019s Lab has published new research in Cell Stem Cell that holds promise to \u201cmend a broken heart\u201d by describing how to directly reprogram human fibroblasts into cardiomyocytes.\u00a0 The research described in the paper, \u201cSingle Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming\u201d, is the first to &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/new-research-from-qian-lab-mcallister-heart-institute\/\" aria-label=\"Read more about New Research from Qian Lab, McAllister Heart Institute\">Read more<\/a><\/p>\n","protected":false},"author":45695,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[86],"tags":[84],"class_list":["post-34487","post","type-post","status-publish","format-standard","hentry","category-cardiology","tag-84","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Research from Qian Lab, McAllister Heart Institute | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, 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content=\"https:\/\/www.med.unc.edu\/medicine\/news\/new-research-from-qian-lab-mcallister-heart-institute\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2019-06-21T18:52:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T21:34:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/mhi\/files\/2019\/06\/Qian-release-226x300.jpg\" \/>\n<meta name=\"author\" content=\"Anna Jojic\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Anna Jojic\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" 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