{"id":41092,"date":"2020-03-26T19:23:11","date_gmt":"2020-03-26T23:23:11","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=41092"},"modified":"2023-06-06T17:52:18","modified_gmt":"2023-06-06T21:52:18","slug":"rose-receives-nci-grant-to-study-immune-checkpoint-inhibition-in-urothelial-cancer","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/rose-receives-nci-grant-to-study-immune-checkpoint-inhibition-in-urothelial-cancer\/","title":{"rendered":"Rose Receives NCI Grant to Study Entinostat Combined With Immune Checkpoint Inhibition in Urothelial Cancer"},"content":{"rendered":"<figure id=\"attachment_6795\" class=\"thumbnail wp-caption alignright\" style=\"width: 273px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6795\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-263x300.jpg\" alt=\"\" width=\"263\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-263x300.jpg 263w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-897x1024.jpg 897w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-768x877.jpg 768w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-1346x1536.jpg 1346w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-1794x2048.jpg 1794w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-600x685.jpg 600w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/Rose_LCCC_Headshot-301x344.jpg 301w\" sizes=\"auto, (max-width: 263px) 100vw, 263px\" \/><figcaption class=\"caption wp-caption-text\">Tracy Rose, MD, MPH<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/tracy-rose\/\">Tracy Rose,<\/a> MD, MPH, assistant professor of medicine in the division of hematology and oncology and member of the UNC Lineberger Comprehensive Cancer Center, received a <a href=\"https:\/\/www.cancer.gov\/\">National Cancer Institute<\/a> K08 grant &#8220;Selective histone deacetylase inhibition with entinostat to enhance the anti-tumor immune response to immune checkpoint inhibition in urothelial cancer.&#8221; This study uses a <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03978624?term=NCT03978624&amp;draw=2&amp;rank=1\">window of opportunity approach<\/a> to investigate whether the addition of entinostat can make immune checkpoint inhibition more effective in patients with muscle-invasive urothelial cancer.<\/p>\n<p>Rose focuses on the development of novel therapies and combination therapies for patients with urologic malignancies, including the design and implementation of clinical trials. She also studies the molecular alterations that contribute to the development of genitourinary cancers. Learn more about Rose <a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/tracy-rose\/\">here.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tracy Rose, MD, MPH, assistant professor of medicine in the division of hematology and oncology and member of the UNC Lineberger Comprehensive Cancer Center, received a National Cancer Institute K08 grant &#8220;Selective histone deacetylase inhibition with entinostat to enhance the anti-tumor immune response to immune checkpoint inhibition in urothelial cancer.&#8221; This study uses a window &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/rose-receives-nci-grant-to-study-immune-checkpoint-inhibition-in-urothelial-cancer\/\" aria-label=\"Read more about Rose Receives NCI Grant to Study Entinostat Combined With Immune Checkpoint Inhibition in Urothelial Cancer\">Read more<\/a><\/p>\n","protected":false},"author":69419,"featured_media":6795,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2,517],"tags":[629],"class_list":["post-41092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-oncology","tag-629","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rose Receives NCI Grant to Study Entinostat Combined With Immune Checkpoint Inhibition in Urothelial Cancer | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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