{"id":4418,"date":"2017-11-14T18:08:44","date_gmt":"2017-11-14T23:08:44","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/new-study-aims-to-reduce-opioid-use-while-managing-chronic-pain\/"},"modified":"2023-06-06T17:21:26","modified_gmt":"2023-06-06T21:21:26","slug":"new-study-aims-to-reduce-opioid-use-while-managing-chronic-pain","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/new-study-aims-to-reduce-opioid-use-while-managing-chronic-pain\/","title":{"rendered":"New study aims to reduce opioid use while managing chronic pain"},"content":{"rendered":"<p><!-- description --><\/p>\n<p><em>A principal investigator of the study is UNC\u2019s Dr. Paul Chelminski, from the division of general medicine and clinical epidemiology, who has extensive experience studying best practices of prescribing and managing long-term opioid use.<\/em><\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/new-study-aims-to-reduce-opioid-use-while-managing-chronic-pain-image2.png\" alt=\"image2\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Paul Chelminski, MD<\/figcaption><\/figure>\n<\/div>\n<div>\n<p><em>(Republished from the UNC Health Care and UNC School of Medicine Newsroom)<\/em><\/p>\n<p>Nearly one-third of Americans suffer from chronic noncancer pain, a condition often treated with opioids. The effectiveness of this chronic opioid therapy is currently unclear and exposes individuals to potential risks, including opioid abuse after therapy.<\/p>\n<p>A new $9 million study, led by RTI International, aims to provide strategies for reducing opioid use among patients who are not benefitting from it while ensuring access to those who are benefitting. RTI will collaborate with the <a href=\"https:\/\/midsouthcdrn.mc.vanderbilt.edu\/\">Mid-South Clinical Data Research Network<\/a> which is centered at Vanderbilt University Medical Center and includes Duke University Health System and the University of North Carolina at Chapel Hill.<\/p>\n<p>\u201cThis project will help patients better understand the risks, benefits and uncertainties associated with opioid use, which is needed for informed consent and is critical given the status of the opioid epidemic,\u201d said <a href=\"https:\/\/www.rti.org\/expert\/lauren-mccormack\">Lauren McCormack<\/a>, PhD, Vice President of RTI\u2019s Public Health Research Division who will lead the study.<\/p>\n<p>More than 1,000 patients from North Carolina and Tennessee, states with high opioid use rates, will be enrolled in the study. Researchers will compare two interventions to evaluate their effect on opioid dosage, physical functioning and pain-related outcomes.<\/p>\n<p>One intervention involves a shared decision-making process where patients and clinicians make evidence-based decisions together that align with the patients\u2019 preferences and values. This approach requires strong communication between the patient and provider about the risks and benefits of treatment options.<\/p>\n<p>The other intervention uses motivational interviewing as a goal-oriented counseling technique to enhance an individual\u2019s motivation for behavior change. This involves cognitive behavioral therapy in group sessions to foster more positive thoughts, emotions and behaviors to help manage pain.<\/p>\n<p>Both intervention groups will also receive care based on the Centers for Disease Control and Prevention\u2019s <a href=\"https:\/\/www.cdc.gov\/drugoverdose\/prescribing\/guideline.html\">new guidelines<\/a> for treating opioid patients, including patient selection for opioid use, goal setting, active monitoring, and reducing misuse and abuse.<\/p>\n<p>\u201cThis project was selected for PCORI funding for its potential to fill an important gap in our understanding of long-term opioid therapy and to give people living with chronic pain useful information to help them weigh the effectiveness and safety of their care options,\u201d said PCORI Executive Director Joe Selby, MD, MPH. \u201cWe look forward to following the study\u2019s progress and working with RTI International to share the results.\u201d<\/p>\n<p>The study funded through a PCORI funding announcement specifically focused on long-term opioid use for people with chronic pain. There is a shortage of high-quality evidence demonstrating the safety and effectiveness of long-term opioid therapy for the management of chronic pain, and to date no large-scale studies have assessed strategies for managing and reducing chronic opioid use in real-world clinical settings.<\/p>\n<p>Principal Investigators from partner institutions include UNC Chapel Hill\u2019s Paul Chelminski, MD, Duke\u2019s Li-Tzy Wu, ScD, and Vanderbilt\u2019s Kristin Archer, PhD will collaborate with McCormack and RTI opioid expert, Mark Edlund, MD, PhD.<\/p>\n<p>\u201cThis clinical trial is intended to retrofit pain management and align it with the sensible recommendation that chronic pain therapy incorporate a strong behavioral medicine component,\u201d explained Chelminski, director of the Physician Assistant Program in UNC\u2019s Department of Allied Health Sciences, and general internist in the Internal Medicine Clinic.<\/p>\n<p>The team will receive input from an advisory panel that includes patients and advocates.<\/p>\n<p><i>RTI International\u2019s <\/i><i>award has been approved pending completion of a business and programmatic review by PCORI staff and issuance of a formal award contract. RTI has an extensive portfolio of research that helps policymakers make informed decisions about the prevention and treatment of opioid-use disorders. To learn more, visit <a href=\"https:\/\/www.rti.org\/news\/supervised-drug-injection-sites-help-prevent-opioid-overdoses-safely-dispose-syringes\">RTI\u2019s Opioid Research webpage<\/a><\/i><i>.<\/i><\/p>\n<p><i>PCORI is an independent, nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers, and clinicians with the evidence-based information needed to make better-informed healthcare decisions. <\/i><i>For more information about PCORI\u2019s funding, visit <a href=\"http:\/\/www.pcori.org\/\">www.pcori.org<\/a><\/i><i>. <a href=\"http:\/\/www.pcori.org\/funding\/opportunities\">http:\/\/www.pcori.org\/funding\/opportunities<\/a><\/i><i> <\/i><\/p>\n<div><i>\u00a0<\/i><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>A principal investigator of the study is UNC\u2019s Dr. Paul Chelminski, from the division of general medicine and clinical epidemiology, who has extensive experience studying best practices of prescribing and managing long-term opioid use.<\/p>\n","protected":false},"author":69419,"featured_media":4419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[98,2],"tags":[67],"class_list":["post-4418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-medicine","category-news","tag-67","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New study aims to reduce opioid use while managing chronic pain | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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