{"id":4513,"date":"2017-07-26T18:50:00","date_gmt":"2017-07-26T22:50:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/unc-project-malawi-looks-forward-to-future-discovery-1\/"},"modified":"2023-06-06T17:22:26","modified_gmt":"2023-06-06T21:22:26","slug":"unc-project-malawi-looks-forward-to-future-discovery-1","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/unc-project-malawi-looks-forward-to-future-discovery-1\/","title":{"rendered":"UNC-Project Malawi Looks Forward to Future Discovery"},"content":{"rendered":"

From a vaccine for malaria to ending the HIV epidemic, UNC infectious diseases researchers in Malawi gear up to take on more challenges in a changing country. UNC Chancellor Carol L. Folt recently visited UNC-Project Malawi, as did Vital Signs Editor Jamie Williams who published the following report.<\/p>\n

\n
\"image2\"
Mina Hosseinipour, MD, MPH, is a professor of medicine in the division of infectious diseases and scientific director of UNC Project-Malawi<\/figcaption><\/figure>\n
\"image3\"
UNC-Project Malawi staff in front of the project’s new annex facility (Photo by Jon Gardiner\/UNC)<\/figcaption><\/figure>\n<\/div>\n
\n

(Republished, with permission, from the UNC Health Care and UNC School of Medicine Newsroom)<\/em><\/p>\n

UNC Project-Malawi<\/a> is a global health success story. From Malawi, a landlocked country in southeastern Africa, emerged the knowledge that helped shape global understanding of HIV and other infectious diseases, while saving millions of lives.<\/p>\n

But in research, answers beget more questions.<\/p>\n

So, what\u2019s next?<\/p>\n

Current work in the field of HIV research continues to build upon past accomplishments like the world-changing HIV Prevention Trials Network\u2019s 052 study, which showed that early treatment of HIV with antiretroviral therapy (ART) could reduce sexual transmission by 96 percent. Clearly, treatment works. And now, a focus of UNC\u2019s work in Malawi is increasing testing and outreach to reach at-risk groups, while also developing the most effective methods of treatment. The goal of this current work is to maximize adherence of people with HIV.<\/p>\n

\u201cSome of our biggest problems in HIV treatment are nonadherence,\u201d said Mina Hosseinipour<\/a>, MD, MPH, UNC Project-Malawi\u2019s Scientific Director. \u201cNow we are working to study solutions, methods and products that may make it easier for people.\u201d<\/p>\n

Patients that do adhere to their ART regimen can now live with HIV under control. Better HIV prognoses have been a major contributor to a 20 year increase in life expectancy in Malawi between 1990 and 2015. But as in the West, aging brings with it other health problems including diabetes, high blood pressure and cancer. Hosseinipour said a key to the long-term success of the health care system in Malawi will be integrating HIV care with the rest of the needs of an aging population.<\/p>\n

And so, while the team at UNC Project-Malawi is constantly working to reach at-risk populations and get patients into treatment as soon as possible after infection, the research focus centers on prevention of new infection.<\/p>\n

The most extensive of these studies, the Antibody Mediated Prevention (AMP) study, is now enrolling HIV negative participants. Led by the HIV Prevention Trials Network<\/a> and HIV Vaccine Trials Network \u2013 UNC is a key participant in both groups \u2013 the AMP study is testing a first-of-its-kind infusion of antibodies delivered via IV once every two months. In the development of traditional vaccines, researchers test a vaccine to see if participants develop antibodies. The AMP study will test whether or not these direct antibody infusions can prevent infection.<\/p>\n

\u201cWe are in the very early stages, but Malawi is an absolutely critical site for this study,\u201d said Myron Cohen<\/a>, MD, Associate Vice Chancellor for Global Health, Director of the Institute for Global Health and Infectious Diseases, and the AMP study\u2019s protocol chair. \u201cAs we\u2019ve said for years, the work in Malawi puts us on the absolute cutting edge of research.\u201d<\/p>\n

\"Myron
Myron Cohen, MD, Associate Vice Chancellor for Global Health, Director of the Institute for Global Health and Infectious Diseases<\/figcaption><\/figure>\n

Other studies are testing the viability of a long-acting injectable as HIV prevention, work that will kick off in the fall of this year.<\/p>\n

\u201cAll of this, either treatment or prevention, is meant to end the epidemic, to make HIV something we don\u2019t have in our next generation. The goal is that it goes the way of small pox,\u201d Hosseinipour said.<\/p>\n

With all of these studies just beginning, Hosseinipour says years of work lie ahead, with results expected to be reported in the next four to five years.<\/p>\n

Progressing towards Malaria Vaccine<\/strong><\/p>\n

UNC Project-Malawi researchers have been working to lessen the impact of malaria in the country for decades. In 2009, the first injection of a malaria vaccine in the third phase of clinical trials was administered in Lilongwe. Over the course of that trial, more than 1,500 Malawian infants were enrolled and followed. That trial found that the vaccine was around 50 percent effective, lower than researchers had hoped, but UNC\u2019s Irving Hoffman, PA, MPH, said that modeling showed the vaccine would save a lot of lives.<\/p>\n

Now, Hoffman, UNC Project-Malawi\u2019s International Director, is overseeing another study to more closely test the vaccine. The original vaccine trial was conducted across 11 countries. This time it will focus on Kenya, Ghana and Malawi.<\/p>\n

Hoffman said UNC\u2019s success implementing previous clinical trials \u2013 including phase III of the malaria trial \u2013 combined with its research infrastructure, was a key reason Malawi was selected for this extension of the malaria vaccine work<\/p>\n

\"Irving
UNC-Project Malawi International Director Irving Hoffman presents during recent visit by UNC Chancellor Carol L. Folt (Photo by Jon Gardiner\/UNC)<\/figcaption><\/figure>\n

Patients are now enrolling in the trial which will ultimately vaccinate 240,000 children between the ages of six months and four years, and monitor them over the course of three years.<\/p>\n

\u201cThere is more work to be done, and more careful study, but we hope this can ultimately help save lives here in Malawi, across Africa, and beyond,\u201d Hoffman said.<\/p>\n

The trial is being run by the WHO and will be implemented in Malawi by UNC, along with the Malawian Ministry of Health, the Wellcome Trust, and the London School of Hygiene and Tropical Medicine.<\/p>\n

While Infectious Disease research continues to form the foundation of UNC\u2019s work in Malawi, research, clinical care, and training have expanded into many other areas. In the coming weeks, Vital Signs will profile the physicians making a difference in the fields of surgery, cancer and women\u2019s health.<\/i><\/p>\n

\u00a0<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

From a vaccine for malaria to ending the HIV epidemic, UNC infectious diseases researchers in Malawi gear up to take on more challenges in a changing country. UNC Chancellor Carol L. Folt recently visited UNC-Project Malawi, as did Vital Signs Editor Jamie Williams who published the following report.<\/p>\n","protected":false},"author":69419,"featured_media":4514,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[67],"class_list":["post-4513","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-67","odd"],"acf":[],"yoast_head":"\nUNC-Project Malawi Looks Forward to Future Discovery | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/unc-project-malawi-looks-forward-to-future-discovery-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC-Project Malawi Looks Forward to Future Discovery | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"From a vaccine for malaria to ending the HIV epidemic, UNC infectious diseases researchers in Malawi gear up to take on more challenges in a changing country. 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