{"id":45678,"date":"2020-08-26T21:50:39","date_gmt":"2020-08-27T01:50:39","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=45678"},"modified":"2023-06-06T17:58:29","modified_gmt":"2023-06-06T21:58:29","slug":"unc-researchers-launch-clinical-trial-for-covid-19-treatments","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/unc-researchers-launch-clinical-trial-for-covid-19-treatments\/","title":{"rendered":"UNC Researchers Launch Clinical Trial for COVID-19 Treatments"},"content":{"rendered":"
\"QA-David-Wohl\"
David Wohl, MD (Credit: TPAN)<\/span><\/figcaption><\/figure>\n

UNC Institute for Global Health and Infectious Diseases researchers have begun phase 2 and phase 3 evaluations of promising treatments for COVID-19. The UNC School of Medicine joins more than 25 initial sites participating in the clinical trials through ACTIV-2, a public-private partnership sponsored by the NIH\u2019s National Institute of Allergy and Infectious Diseases to coordinate COVID-19 research and speed development of the most promising treatments and vaccines. This two-phase trial is being conducted by the AIDS Clinical Trials Group to evaluate the safety and efficacy of treatments for adults who have COVID-19 but do not require hospitalization.<\/p>\n

\u201cPeople living in the Triangle area who have recently been diagnosed with COVID-19 and are not hospitalized have the opportunity to make a huge contribution by participating in this study,\u201d said David Wohl<\/strong><\/a>, MD, professor of medicine in the division of infectious diseases and principal investigator for the study at the UNC School of Medicine and a vice chair of the ACTG study team.<\/p>\n

\"\"
Joseph Eron, MD<\/figcaption><\/figure>\n

The phase 2 evaluation of treatments involves determining the safety, antiviral activity, and ability of investigational agents to reduce the duration of COVID-19 symptoms over 28 days. These agents will be selected based on the presence of\u00a0in vitro<\/i>\u00a0data demonstrating activity against SARS-CoV-2 and phase 1 pharmacokinetics and safety data. Half of the 220 study participants will receive the investigational agent and be compared to the participants receiving a placebo. Any agent that demonstrates positive results and meets study-defined criteria will advance to phase 3, in which 1,000 participants will receive the agent and be compared to 1,000 participants receiving a placebo.<\/p>\n

Joseph Eron<\/strong><\/a>, MD, chief of the division of infectious diseases, co-chairs ACTG.<\/p>\n

\u201cWe strongly believe that evaluating antiviral therapy early in the treatment of COVID-19 is essential and effective therapy that will prevent worsening illness and hospitalization and may have the added benefit of reducing the risk of SARS-CoV-2 transmission,\u201d said Eron. \u201cACTIV-2 is changing our approach to fighting this infection and is a major contribution to the response of science to ending the COVID-19 pandemic.\u201d<\/p>\n

Learn more from the UNC Health and UNC School of Medicine Newsroom<\/a><\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

UNC Institute for Global Health and Infectious Diseases researchers have begun phase 2 and phase 3 evaluations of promising treatments for COVID-19. The UNC School of Medicine joins more than 25 initial sites participating in the clinical trials through ACTIV-2, a public-private partnership sponsored by the NIH\u2019s National Institute of Allergy and Infectious Diseases to … Read more<\/a><\/p>\n","protected":false},"author":69419,"featured_media":42075,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[100,2],"tags":[629],"class_list":["post-45678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infectious-diseases","category-news","tag-629","odd"],"acf":[],"yoast_head":"\nUNC Researchers Launch Clinical Trial for COVID-19 Treatments | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/unc-researchers-launch-clinical-trial-for-covid-19-treatments\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC Researchers Launch Clinical Trial for COVID-19 Treatments | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"UNC Institute for Global Health and Infectious Diseases researchers have begun phase 2 and phase 3 evaluations of promising treatments for COVID-19. 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