{"id":4761,"date":"2018-03-29T03:14:30","date_gmt":"2018-03-29T07:14:30","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/peanut-allergy-therapy-proves-effective-during-phase-3-clinical-trial\/"},"modified":"2023-06-06T17:24:52","modified_gmt":"2023-06-06T21:24:52","slug":"peanut-allergy-therapy-proves-effective-during-phase-3-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/peanut-allergy-therapy-proves-effective-during-phase-3-clinical-trial\/","title":{"rendered":"Peanut allergy therapy proves effective during phase 3 clinical trial"},"content":{"rendered":"

<\/p>\n

Wesley Burks, MD, was a principal investigator on the phase 3 PALISADE trial to determine the efficacy of the AR101 oral immunotherapy developed by Aimmune Therapeutics for people allergic to peanuts.<\/em><\/p>\n

\n
\"image2\"
Dr. Wesley Burks<\/figcaption><\/figure>\n<\/div>\n
\n

(Republished from the UNC School of Medicine and UNC Health Care Newsroom)<\/em><\/p>\n

Aimmune Therapeutics, Inc., a biopharmaceutical company developing treatments for potentially life-threatening food allergies, announced this week that its phase 3 PALISADE efficacy trial of the AR101 immunotherapy treatment met the primary endpoint.<\/p>\n

PALISADE enrolled 499 patients ages 4 to 17, 496 of whom received treatment. After approximately one year of treatment, patients completed an exit double-blind, placebo-controlled food challenge. About 67 percent of AR101 patients tolerated a single highest dose of at least 600 mg of peanut protein with no more than mild symptoms. Also, 50.3 percent of AR101 patients tolerated a single highest dose of 1000 mg of peanut protein.<\/p>\n

\u201cIt\u2019s exciting to see this large-scale study confirm that a characterized approach to oral immunotherapy, in an appropriately supervised clinical setting, holds promise for becoming an approved treatment,\u201d said A. Wesley Burks, MD, Executive Dean and Curnen Distinguished Professor of Pediatrics at the UNC School of Medicine, and a principal investigator for PALISADE. \u201c<\/p>\n

It\u2019s great to see patients who could tolerate just a tiny bit of peanut protein \u2013 at most, a tenth of a peanut \u2013 to now successfully eating the equivalent of two to four peanuts with nothing more than mild, transient symptoms, if any at all. Patients and their families are highly motivated to pursue an effective treatment for peanut allergy, and AR101 could give them a comfortable margin of safety in case of accidental exposures.\u201d<\/p>\n

Burks leads the UNC Food Allergy Institute<\/a>, a team of researchers dedicated to finding new ways to help children and adults who suffer from food allergies.<\/p>\n

Read more about the study at the Aimmune Therapeutics website<\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

Wesley Burks, MD, was a principal investigator on the phase 3 PALISADE trial to determine the efficacy of the AR101 oral immunotherapy developed by Aimmune Therapeutics for people allergic to peanuts.<\/p>\n","protected":false},"author":69419,"featured_media":4762,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[22],"class_list":["post-4761","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-22","odd"],"acf":[],"yoast_head":"\nPeanut allergy therapy proves effective during phase 3 clinical trial | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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