{"id":47827,"date":"2020-11-19T12:30:53","date_gmt":"2020-11-19T17:30:53","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=47827"},"modified":"2023-06-06T18:02:17","modified_gmt":"2023-06-06T22:02:17","slug":"mottl-receives-nih-r01-grant-to-study-impact-of-diabetes-on-patients-with-glomerular-diseases","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/mottl-receives-nih-r01-grant-to-study-impact-of-diabetes-on-patients-with-glomerular-diseases\/","title":{"rendered":"Mottl Receives NIH R01 Grant to Study Impact of Diabetes on Patients with Glomerular Diseases"},"content":{"rendered":"<figure id=\"attachment_4223\" class=\"thumbnail wp-caption alignright\" style=\"width: 250px\"><a href=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/polycystic-kidney-disease-mottl-image2.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4223\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/polycystic-kidney-disease-mottl-image2-240x300.jpeg\" alt=\"Amy Mottl, MD, MPH\" width=\"240\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/polycystic-kidney-disease-mottl-image2-240x300.jpeg 240w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/polycystic-kidney-disease-mottl-image2-301x376.jpeg 301w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/polycystic-kidney-disease-mottl-image2.jpeg 500w\" sizes=\"auto, (max-width: 240px) 100vw, 240px\" \/><\/a><figcaption class=\"caption wp-caption-text\"><span class=\"discreet\">Amy Mottl, MD, MPH<\/span><\/figcaption><\/figure>\n<p><strong><a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/amy-mottl-md-mph\/\">Amy Mottl<\/a><\/strong>, MD, MPH, associate professor in the division of nephrology and hypertension, is receiving a five-year NIH Multi PI R01 grant award for \u201cThe Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes.\u201d<\/p>\n<p>IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), and membranous nephropathy (MN) are rare glomerular diseases that cause significant individual and societal morbidity. Diabetes mellitus is a common comorbidity of these glomerular diseases and may alter their diagnosis, treatment and long-term outcomes. CureGN-Diabetes is a longitudinal, observational ancillary study to CureGN (which does not include patients with diabetes), aimed at understanding and ameliorating the impact of diabetes on patients with glomerular diseases.<\/p>\n<p>The aims of CureGN-GN Diabetes include: 1) To recruit and follow a multiethnic cohort of 300 adult patients with diabetes mellitus and biopsy documented IgAN, FSGS, MN, and MCD; 2) To assess the impact of diabetes on presenting features (clinical and histopathologic) and long- term outcomes in patients with IgAN, FSGS, MN, and MCD; AND 3) To identify individual and clusters of morphologic lesions which carry diagnostic and prognostic value. A strength of this study is the significant overlap between investigators and clinical sites involved in the CureGN and TRIDENT studies, which will expedite the efficiency and productivity emanating from this work. Furthermore, the CureGN-Diabetes Study will add to the available biorepositories of CureGN and TRIDENT, enriching the resources for future biomarker and mechanistic studies of primary glomerular disease versus diabetes-mediated pathways.<\/p>\n<p>Other principal investigators include <strong>Andy Bomback<\/strong>, MD (Columbia University), <strong>Jonathan Hogan<\/strong>, MD (University of Pennsylvania School of Medicine) and <strong>Cynthia Nast<\/strong>, MD (Cedars-Sinai Medical Center).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amy Mottl, MD, MPH, associate professor in the division of nephrology and hypertension, is receiving a five-year NIH Multi PI R01 grant award for \u201cThe Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes.\u201d IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), and membranous nephropathy (MN) are rare glomerular diseases that cause &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/mottl-receives-nih-r01-grant-to-study-impact-of-diabetes-on-patients-with-glomerular-diseases\/\" aria-label=\"Read more about Mottl Receives NIH R01 Grant to Study Impact of Diabetes on Patients with Glomerular Diseases\">Read more<\/a><\/p>\n","protected":false},"author":69419,"featured_media":4570,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[101,2],"tags":[629],"class_list":["post-47827","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nephrology","category-news","tag-629","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mottl Receives NIH R01 Grant to Study Impact of Diabetes on Patients with Glomerular Diseases | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/mottl-receives-nih-r01-grant-to-study-impact-of-diabetes-on-patients-with-glomerular-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mottl Receives NIH R01 Grant to Study Impact of Diabetes on Patients with Glomerular Diseases | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Amy Mottl, MD, MPH, associate professor in the division of nephrology and hypertension, is receiving a five-year NIH Multi PI R01 grant award for \u201cThe Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes.\u201d IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), and membranous nephropathy (MN) are rare glomerular diseases that cause &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/mottl-receives-nih-r01-grant-to-study-impact-of-diabetes-on-patients-with-glomerular-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-19T17:30:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T22:02:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/asn2019s-kidney-week-2018-selects-dr-amy-mottl2019s-paper-for-201cbest-of201d-session-image2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"550\" \/>\n\t<meta property=\"og:image:height\" content=\"708\" \/>\n\t<meta property=\"og:image:type\" 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