{"id":4821,"date":"2018-01-03T19:50:00","date_gmt":"2018-01-04T00:50:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure\/"},"modified":"2023-06-06T17:25:33","modified_gmt":"2023-06-06T21:25:33","slug":"the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure\/","title":{"rendered":"The UNC McAllister Heart Institute Receives a Grant to Advance a Novel Therapy for Heart Failure"},"content":{"rendered":"<p><!-- description --><\/p>\n<p><em>A $1.9 Million NIH grant will enable new studies of alpha-1-adrenergic receptors in the heart. Dr. Brian Colwell Jensen, an associate professor in the division of cardiology and the department of pharmacology, will serve as principal investigator for research that considers how metabolic alterations provide cardioprotection.<\/em><\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure-image2.jpeg\" alt=\"image2\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Dr. Brian Colwell Jensen (Photo credit: Chris Polydoroff)<\/figcaption><\/figure>\n<\/div>\n<div>\n<p>Dr. Brian Colwell Jensen with the UNC McAllister Heart Institute has received a $1.9 million NIH R01 grant to expand recent findings that alpha-1A adrenergic receptors (ARs) protect the failing heart by providing more energy for heart muscle cells through more efficient glucose metabolism and enhanced mitochondrial function.<\/p>\n<p>Epinephrine and norepinephrine are known to activate both alpha-1 and beta-ARs in the heart, and chronic stimulation of beta-ARs by elevated levels of these hormones contributes to heart failure. In contrast, activation of alpha-1-ARs protects the heart, though the mechanisms that account for this benefit are not completely understood.<\/p>\n<p>\u201cWe are really excited to continue our exploration of the protective roles that the alpha-1A adrenergic receptor subtype plays in the failing heart,\u201d said Dr. Jensen. \u201cThese receptors are activated by adrenaline (epinephrine) as part of the body\u2019s chronic stress response to heart failure. We believe their activation may mitigate some of the harmful effects of chronic beta adrenergic receptor stimulation.\u201d<\/p>\n<p>Dr. Jensen\u2019s team will use a safe oral drug to selectively stimulate alpha-1A-ARs in experiments. Drugs that target beta receptors (beta blockers) are central to the treatment of heart failure and the Jensen lab\u2019s recent work lays the groundwork for the long-term goal of developing a novel therapy for heart failure that selectively stimulates the alpha-1A-AR.<\/p>\n<p>\u201cAs a scientist, I\u2019m energized by the opportunity to learn more about the way the heart works,\u201d said Dr. Jensen. \u201cAs an advanced heart failure cardiologist, I\u2019m motivated by the crucial need for more and better ways to help patients with heart failure.&#8221;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>A $1.9 Million NIH grant will enable new studies of alpha-1-adrenergic receptors in the heart. Dr. Brian Colwell Jensen, an associate professor in the division of cardiology and the department of pharmacology, will serve as principal investigator for research that considers how metabolic alterations provide cardioprotection.<\/p>\n","protected":false},"author":69419,"featured_media":4822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[86,2],"tags":[22],"class_list":["post-4821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiology","category-news","tag-22","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The UNC McAllister Heart Institute Receives a Grant to Advance a Novel Therapy for Heart Failure | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The UNC McAllister Heart Institute Receives a Grant to Advance a Novel Therapy for Heart Failure | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"A $1.9 Million NIH grant will enable new studies of alpha-1-adrenergic receptors in the heart. Dr. Brian Colwell Jensen, an associate professor in the division of cardiology and the department of pharmacology, will serve as principal investigator for research that considers how metabolic alterations provide cardioprotection.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2018-01-04T00:50:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T21:25:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/the-unc-mcallister-heart-institute-receives-a-grant-to-advance-a-novel-therapy-for-heart-failure-image2-scaled.jpeg\" 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