{"id":49953,"date":"2021-02-25T11:29:55","date_gmt":"2021-02-25T16:29:55","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=49953"},"modified":"2023-06-06T18:06:49","modified_gmt":"2023-06-06T22:06:49","slug":"vtv-therapeutics-announces-results-from-simplicit-1-study-of-ttp399-in-patients-with-type-1-diabetes","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/vtv-therapeutics-announces-results-from-simplicit-1-study-of-ttp399-in-patients-with-type-1-diabetes\/","title":{"rendered":"vTv Therapeutics Announces Results from SimpliciT-1 Study of TTP399 in Patients with Type 1 Diabetes"},"content":{"rendered":"<figure id=\"attachment_6453\" class=\"thumbnail wp-caption alignright\" style=\"width: 224px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6453\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-214x300.jpg\" alt=\"KleinKlara\" width=\"214\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-214x300.jpg 214w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-731x1024.jpg 731w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-768x1075.jpg 768w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-1097x1536.jpg 1097w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-1463x2048.jpg 1463w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-600x840.jpg 600w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara-301x421.jpg 301w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara.jpg 1500w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><figcaption class=\"caption wp-caption-text\">Klara Klein, MD, PhD<\/figcaption><\/figure>\n<p><span class=\"TextRun  BCX0 SCXW153368365\" lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun  BCX0 SCXW153368365\" data-ccp-parastyle=\"No Spacing\">Led by <a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/klara-klein\/\">Klara Klein<\/a>, MD, PhD, a fellow in the division of endocrinology and metabolism, the study showed that treatment with 800mg of TTP399 demonstrated statistically significant reductions in HbA1c and clinically relevant reduction in the frequency of severe or symptomatic hypoglycemia.<\/span><\/span><span class=\"EOP  BCX0 SCXW153368365\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p>Learn more from the <a href=\"https:\/\/news.unchealthcare.org\/2021\/02\/vtv-therapeutics-announces-publication-of-results-in-diabetes-care-from-simplicit-1-study-of-ttp399-in-patients-with-type-1-diabetes\/\">UNC Health and UNC School of Medicine Newsroom<\/a>.<\/p>\n<p>Dr. Klein is a member of the <a href=\"https:\/\/www.med.unc.edu\/medicine\/education\/physician-scientist\/\">PSTP Program<\/a>, planning to fast-track into endocrinology and study diabetes and obesity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Led by Klara Klein, MD, PhD, a fellow in the division of endocrinology and metabolism, the study showed that treatment with 800mg of TTP399 demonstrated statistically significant reductions in HbA1c and clinically relevant reduction in the frequency of severe or symptomatic hypoglycemia.\u00a0 Learn more from the UNC Health and UNC School of Medicine Newsroom. Dr. &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/vtv-therapeutics-announces-results-from-simplicit-1-study-of-ttp399-in-patients-with-type-1-diabetes\/\" aria-label=\"Read more about vTv Therapeutics Announces Results from SimpliciT-1 Study of TTP399 in Patients with Type 1 Diabetes\">Read more<\/a><\/p>\n","protected":false},"author":69419,"featured_media":6453,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[96,2],"tags":[630],"class_list":["post-49953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endocrinology-metabolism","category-news","tag-630","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>vTv Therapeutics Announces Results from SimpliciT-1 Study of TTP399 in Patients with Type 1 Diabetes | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/vtv-therapeutics-announces-results-from-simplicit-1-study-of-ttp399-in-patients-with-type-1-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"vTv Therapeutics Announces Results from SimpliciT-1 Study of TTP399 in Patients with Type 1 Diabetes | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Led by Klara Klein, MD, PhD, a fellow in the division of endocrinology and metabolism, the study showed that treatment with 800mg of TTP399 demonstrated statistically significant reductions in HbA1c and clinically relevant reduction in the frequency of severe or symptomatic hypoglycemia.\u00a0 Learn more from the UNC Health and UNC School of Medicine Newsroom. Dr. &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/vtv-therapeutics-announces-results-from-simplicit-1-study-of-ttp399-in-patients-with-type-1-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-25T16:29:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T22:06:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/KleinKlara.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"2100\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kim Morris\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta 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