{"id":50024,"date":"2021-03-12T15:46:10","date_gmt":"2021-03-12T20:46:10","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=50024"},"modified":"2023-06-06T18:07:17","modified_gmt":"2023-06-06T22:07:17","slug":"evidence-review-examines-both-benefits-and-harms-for-lung-cancer-screening","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/evidence-review-examines-both-benefits-and-harms-for-lung-cancer-screening\/","title":{"rendered":"Evidence Review Examines Both Benefits and Harms For Lung Cancer Screening"},"content":{"rendered":"<figure id=\"attachment_4487\" class=\"thumbnail wp-caption alignright\" style=\"width: 276px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4487\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/strategy-significantly-boosts-colorectal-screening-for-groups-with-low-rates-1-image2.png\" alt=\"Daniel S. Reuland, MD, MPH\" width=\"266\" height=\"267\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/strategy-significantly-boosts-colorectal-screening-for-groups-with-low-rates-1-image2.png 266w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/strategy-significantly-boosts-colorectal-screening-for-groups-with-low-rates-1-image2-150x150.png 150w\" sizes=\"auto, (max-width: 266px) 100vw, 266px\" \/><figcaption class=\"caption wp-caption-text\">Daniel S. Reuland, MD, MPH<\/figcaption><\/figure>\n<p>A comprehensive review by University of North Carolina researchers and colleagues of hundreds of publications, incorporating more than two dozen articles on prevention screening for lung cancer with low-dose spiral computed tomography (LDCT), shows there are both benefits and harms from screening. The review was published in <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2777242\">JAMA<\/a> on March 9, 2021.<\/p>\n<p>The results of the decade long National Lung Screening Trial (NLST) showed that LDCT could detect lung cancer better than conventional X-rays in current or previous heavy smokers. Based on those results, the United States Preventive Services Task Force (USPSTF) initially recommended low-dose CT screening for people ages 55 to 80 with a 30 pack-year smoking history. Subsequently, other screening trial results have been published, including a European trial called NELSON, the next-largest study to the NLST. NELSON also found a reduction in deaths due to lung cancer because of screening.<\/p>\n<p>It has been nearly a decade since the initial recommendations were formulated, so the USPSTF initiated an updated review of the evidence. UNC scientists and their collaborators evaluated and synthesized data from the seven trials to arrive at a comprehensive, current assessment of harms and benefits of screening.<\/p>\n<p>New recommendations, based on this evidence review, broaden the criteria for screening eligibility by lowering the screening age from 55 to 50 and reducing the pack-year requirement from 30 to 20 pack-years. There were several reasons for this change in eligibility according to the reviewers; one was to promote health equity, in part because African Americans have higher lung cancer risk even with lower levels of smoking exposure.<\/p>\n<p>\u201cTwo large studies have now confirmed that screening can lower the chance of dying of lung cancer in high-risk people. However, people considering screening should know that a relatively small number of people who are screened benefit, and that screening can also lead to real harms,\u201d said\u00a0<a href=\"https:\/\/unclineberger.org\/directory\/daniel-s-reuland\/\">Daniel Reuland, MD, MPH<\/a>, one of the review authors, professor in the division of general medicine and clinical epidemiology and a member of the UNC Lineberger Comprehensive Cancer Center.<\/p>\n<p>Read more from <a href=\"https:\/\/unclineberger.org\/news\/evidence-review-examines-both-benefits-and-harms-for-lung-cancer-screening\/\">UNC Lineberger<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A comprehensive review by University of North Carolina researchers and colleagues of hundreds of publications, incorporating more than two dozen articles on prevention screening for lung cancer with low-dose spiral computed tomography (LDCT), shows there are both benefits and harms from screening. The review was published in JAMA on March 9, 2021. The results of &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/evidence-review-examines-both-benefits-and-harms-for-lung-cancer-screening\/\" aria-label=\"Read more about Evidence Review Examines Both Benefits and Harms For Lung Cancer Screening\">Read more<\/a><\/p>\n","protected":false},"author":69419,"featured_media":4487,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[98,2],"tags":[630],"class_list":["post-50024","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-medicine","category-news","tag-630","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evidence Review Examines Both Benefits and Harms For Lung Cancer Screening | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/evidence-review-examines-both-benefits-and-harms-for-lung-cancer-screening\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evidence Review Examines Both Benefits and Harms For Lung Cancer Screening | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"A comprehensive review by University of North Carolina researchers and colleagues of hundreds of publications, incorporating more than two dozen articles on prevention screening for lung cancer with low-dose spiral computed tomography (LDCT), shows there are both benefits and harms from screening. The review was published in JAMA on March 9, 2021. The results of &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/evidence-review-examines-both-benefits-and-harms-for-lung-cancer-screening\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-12T20:46:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T22:07:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/strategy-significantly-boosts-colorectal-screening-for-groups-with-low-rates-1-image2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"266\" \/>\n\t<meta property=\"og:image:height\" content=\"267\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Kim Morris\" \/>\n<meta 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