{"id":53268,"date":"2021-07-05T09:52:59","date_gmt":"2021-07-05T13:52:59","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=53268"},"modified":"2023-06-06T18:12:12","modified_gmt":"2023-06-06T22:12:12","slug":"whats-best-for-diabetes-after-metformin","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/","title":{"rendered":"What&#8217;s Best for Diabetes After Metformin?"},"content":{"rendered":"<div id=\"article-content\">\n<div id=\"pageN_1\" class=\"csdpages\">\n<figure id=\"attachment_34408\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-34408\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/10\/john-buse-podcast-300x235.jpg\" alt=\"john-buse\" width=\"300\" height=\"235\" \/><figcaption class=\"caption wp-caption-text\">John Buse, MD<\/figcaption><\/figure>\n<p>Results of the five-year GRADE trial, designed to understand the best second-line agent for patients with type 2 diabetes already taking metformin, were reported at the virtual American Diabetes Association (ADA) 81st Scientific Sessions and published in\u00a0<a href=\"https:\/\/www.medscape.com\/viewarticle\/954008?src=#vp_3\">Medscape Medical News<\/a>.<\/p>\n<p>Researchers found the injectable drugs Lantus (glargine) and Victoza (liraglutide) outperformed the pills Amaryl (glimepiride) and Januvia (sitagliptin).<\/p>\n<\/div>\n<\/div>\n<p>For the endpoint of any cardiovascular event, the rate was 5.8% for patients taking liraglutide, significantly less than the rate of 7.6% of those taking insulin glargine, 8.0% for glimepiride, and 8.6% for sitagliptin, reported <a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/john-buse-md-phd\/\">John B. Buse, MD, PhD<\/a>, professor of medicine in the division of endocrinology and metabolism.<\/p>\n<p>Funded by the U.S. National Institutes of Health, the study included more than 5,000 people with type 2 diabetes and average age was 57.<\/p>\n<p><a href=\"https:\/\/www.medscape.com\/viewarticle\/954008?src=#vp_3\">Read the article<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Results of the five-year GRADE trial, designed to understand the best second-line agent for patients with type 2 diabetes already taking metformin, were reported at the virtual American Diabetes Association (ADA) 81st Scientific Sessions and published in\u00a0Medscape Medical News. Researchers found the injectable drugs Lantus (glargine) and Victoza (liraglutide) outperformed the pills Amaryl (glimepiride) and &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\" aria-label=\"Read more about What&#8217;s Best for Diabetes After Metformin?\">Read more<\/a><\/p>\n","protected":false},"author":69419,"featured_media":34408,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[96,2,583],"tags":[630],"class_list":["post-53268","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endocrinology-metabolism","category-news","category-research-news","tag-630","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What&#039;s Best for Diabetes After Metformin? | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What&#039;s Best for Diabetes After Metformin? | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Results of the five-year GRADE trial, designed to understand the best second-line agent for patients with type 2 diabetes already taking metformin, were reported at the virtual American Diabetes Association (ADA) 81st Scientific Sessions and published in\u00a0Medscape Medical News. Researchers found the injectable drugs Lantus (glargine) and Victoza (liraglutide) outperformed the pills Amaryl (glimepiride) and &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-05T13:52:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T22:12:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/10\/john-buse-podcast-e1612285894585.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"245\" \/>\n\t<meta property=\"og:image:height\" content=\"252\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kim Morris\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kim Morris\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\"},\"author\":{\"name\":\"Kim Morris\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#\/schema\/person\/9a358414a53d5237f9ba3f8daa55c529\"},\"headline\":\"What&#8217;s Best for Diabetes After Metformin?\",\"datePublished\":\"2021-07-05T13:52:59+00:00\",\"dateModified\":\"2023-06-06T22:12:12+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\"},\"wordCount\":147,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/10\/john-buse-podcast-e1612285894585.jpg\",\"keywords\":[\"2021\"],\"articleSection\":[\"Endocrinology and Metabolism\",\"News\",\"Research News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\",\"url\":\"https:\/\/www.med.unc.edu\/medicine\/news\/whats-best-for-diabetes-after-metformin\/\",\"name\":\"What's Best for Diabetes After Metformin? 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