{"id":61284,"date":"2022-09-13T10:30:18","date_gmt":"2022-09-13T14:30:18","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=61284"},"modified":"2023-06-06T18:21:48","modified_gmt":"2023-06-06T22:21:48","slug":"rubin-styner-publish-the-skeleton-in-a-physical-world","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/rubin-styner-publish-the-skeleton-in-a-physical-world\/","title":{"rendered":"Drs. Rubin, Styner Publish &#8220;The Skeleton in a Physical World&#8221;"},"content":{"rendered":"<p><em><a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/janet-rubin-md\/\">Janet Rubin, MD,<\/a> is the Sarah Graham Kenan Distinguished Professor of Medicine in the <a href=\"https:\/\/www.med.unc.edu\/medicine\/endocrinology-metabolism\/\">Division of Endocrinology and Metabolism<\/a> and vice chair for research in the Department of Medicine. <a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/maya-styner-md\/\">Maya Styner, MD<\/a> is an associate professor of medicine in the Division of Endocrinology and Metabolism.\u00a0<\/em><\/p>\n<p>In the article, Drs. Rubin and Styner consider how the cells responsible for remodeling skeletal structure respond to mechanical force including load magnitude, frequency, and cyclicity, and how force rearranges cellular structure in turn. They address the effects of these forces to balance the mesenchymal stem cell supply of bone-forming osteoblasts and energy storing adipocytes. That this phenotypic switching is achieved at the level of both gene transactivation and alteration of structural epigenetic controls of gene expression is considered. How this information relates to a prescriptive for exercise is also explored.<\/p>\n<p><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/15353702221113861\">Read the article here.\u00a0<\/a><\/p>\n<figure id=\"attachment_4337\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4337\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/another-reason-to-exercise-burning-bone-fat-2013-a-key-to-better-bone-health-image2-300x260.png\" alt=\"Maya Styner, MD, is an assistant professor in Medicine's Division of Endocrinology and Metabolism\" width=\"300\" height=\"260\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/another-reason-to-exercise-burning-bone-fat-2013-a-key-to-better-bone-health-image2-300x260.png 300w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/another-reason-to-exercise-burning-bone-fat-2013-a-key-to-better-bone-health-image2-301x260.png 301w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/another-reason-to-exercise-burning-bone-fat-2013-a-key-to-better-bone-health-image2.png 341w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"caption wp-caption-text\">Maya Styner, MD,<\/figcaption><\/figure>\n<figure id=\"attachment_58854\" class=\"thumbnail wp-caption alignright\" style=\"width: 278px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-58854\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22-268x300.png\" alt=\"\" width=\"268\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22-268x300.png 268w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22-915x1024.png 915w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22-768x860.png 768w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22-600x672.png 600w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22-301x337.png 301w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/04\/Janet-Rubin-HeadShot-22.png 1190w\" sizes=\"auto, (max-width: 268px) 100vw, 268px\" \/><figcaption class=\"caption wp-caption-text\">Janet Rubin, MD<\/p><\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Janet Rubin, MD, is the Sarah Graham Kenan Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism and vice chair for research in the Department of Medicine. Maya Styner, MD is an associate professor of medicine in the Division of Endocrinology and Metabolism.\u00a0 In the article, Drs. Rubin and Styner consider how the &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/rubin-styner-publish-the-skeleton-in-a-physical-world\/\" aria-label=\"Read more about Drs. Rubin, Styner Publish &#8220;The Skeleton in a Physical World&#8221;\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":61291,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[96,2],"tags":[631],"class_list":["post-61284","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endocrinology-metabolism","category-news","tag-631","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Drs. Rubin, Styner Publish &quot;The Skeleton in a Physical World&quot; | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/rubin-styner-publish-the-skeleton-in-a-physical-world\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Drs. Rubin, Styner Publish &quot;The Skeleton in a Physical World&quot; | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Janet Rubin, MD, is the Sarah Graham Kenan Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism and vice chair for research in the Department of Medicine. Maya Styner, MD is an associate professor of medicine in the Division of Endocrinology and Metabolism.\u00a0 In the article, Drs. Rubin and Styner consider how the &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/rubin-styner-publish-the-skeleton-in-a-physical-world\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-13T14:30:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T22:21:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2022\/09\/Screen-Shot-2022-09-13-at-10.23.13-AM.png\" \/>\n\t<meta property=\"og:image:width\" content=\"866\" \/>\n\t<meta property=\"og:image:height\" content=\"730\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Morgan Duerden\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgan Duerden\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/rubin-styner-publish-the-skeleton-in-a-physical-world\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/rubin-styner-publish-the-skeleton-in-a-physical-world\/\"},\"author\":{\"name\":\"Morgan Duerden\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#\/schema\/person\/99bd6d3f6c7b07d9e318254957f14bf9\"},\"headline\":\"Drs. 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