{"id":61483,"date":"2022-09-29T08:48:25","date_gmt":"2022-09-29T12:48:25","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=61483"},"modified":"2023-06-06T18:22:11","modified_gmt":"2023-06-06T22:22:11","slug":"bionic-pancreas-improves-type-1-diabetes-management-compared-to-standard-insulin-delivery-methods","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/bionic-pancreas-improves-type-1-diabetes-management-compared-to-standard-insulin-delivery-methods\/","title":{"rendered":"Bionic Pancreas Improves Type 1 Diabetes Management Compared to Standard Insulin Delivery Methods"},"content":{"rendered":"
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This nationwide clinical trial funded through the National Institutes of Health including participation from patients at the UNC Diabetes Center, led by John Buse, MD, PhD.<\/em><\/p>\n<\/div>\n

\"John<\/a>
John Buse, MD, PhD<\/figcaption><\/figure>\n

A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective at maintaining blood glucose (sugar) levels within normal range than standard-of-care management among people with type 1 diabetes<\/a>, a new multicenter clinical trial has found. The trial, conducted partly at UNC-Chapel Hill was primarily funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)<\/a>, part of the National Institutes of Health<\/a>, and published in the New England Journal of Medicine<\/em><\/a>.<\/p>\n<\/div>\n

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Automated insulin delivery systems, also called artificial pancreas<\/a> or closed-loop control systems, track a person\u2019s blood glucose levels using a continuous glucose monitor <\/a>and automatically deliver the hormone insulin when needed using an insulin pump. These systems replace reliance on testing glucose level by fingerstick, continuous glucose monitor with separate insulin delivery through multiple daily injections, or a pump without automation.<\/p>\n<\/div>\n

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Compared to other available artificial pancreas technologies, the bionic pancreas requires less user input and provides more automation because the device\u2019s algorithms continually adjust insulin doses automatically based on users\u2019 needs. Users initialize the bionic pancreas by entering their body weight into the device\u2019s dosing software at the time of first use.<\/p>\n<\/div>\n

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Users of the bionic pancreas also do not have to count carbohydrates, nor initiate doses of insulin to correct for high blood glucose. In addition, health care providers do not need to make periodic adjustments to the settings of the device.<\/p>\n<\/div>\n

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\u201cWhat is attractive about this device is that it requires so little input from the patient,\u201d \u00a0said\u00a0John Buse, MD, PhD<\/a>. \u201cThe hour by hour, every day for the rest of your life burden of type 1 diabetes can be crushing for some.\u00a0 This technology takes some of the weight off the backs of people living with diabetes.\u201d<\/p>\n<\/div>\n

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\u00a0The 13-week trial, conducted at UNC-Chapel Hill under the leadership of John Buse, MD, PhD, director of the UNC Diabetes Center, and 15 other clinical sites across the United States, enrolled 326 participants ages 6 to 79 years who had type 1 diabetes and had been using insulin for at least one year. Participants were randomly assigned to either a treatment group using the bionic pancreas device or a standard-of-care control group using their personal pre-study insulin delivery method. All participants in the control group were provided with a continuous glucose monitor, and nearly one-third of the control group were using commercially available artificial pancreas technology during the study.<\/p>\n<\/div>\n

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In participants using the bionic pancreas, glycated hemoglobin, a measure of a person\u2019s long-term blood glucose control, improved from 7.9% to 7.3%, yet remained unchanged among the standard-of-care control group. The bionic pancreas group participants spent 11% more time, approximately 2.5 hours per day, within the targeted blood glucose range compared to the control group. These results were similar in youth and adult participants, and improvements in blood glucose control were greatest among participants who had higher blood glucose levels at the beginning of the study.<\/p>\n<\/div>\n

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Hyperglycemia, or high blood glucose, caused by problems with insulin pump equipment, was the most frequently reported adverse event in the bionic pancreas group. The number of mild hypoglycemia<\/a> events, or low blood glucose, was low and was not different between the groups. The frequency of severe hypoglycemia was not statistically different between the standard of care and bionic pancreas groups.<\/p>\n<\/div>\n

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Four companion papers were also published in Diabetes Technology and Therapeutics<\/em> two of which provided more detailed results among the adult and youth participants. The third paper reported results from an extension study in which the participants from the standard-of-care control group switched to using the bionic pancreas for 13 weeks and experienced improvements in glucose control similar to the bionic pancreas group in the randomized trial. In the fourth paper, results showed that using the bionic pancreas with a faster-acting insulin in 114 adult participants improved glucose control as effectively as using the device with standard insulin.<\/p>\n<\/div>\n

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The study is one of several pivotal trials funded by NIDDK to advance artificial pancreas technology and look at factors including safety, efficacy, user-friendliness, physical and emotional health of participants, and cost. To date, these trials have provided the important safety and efficacy data needed for regulatory review and licensure to make the technology commercially available. The Jaeb Center for Health Research in Tampa, Florida, served as coordinating center.<\/p>\n<\/div>\n

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John Buse<\/i><\/a> is the Verne S. Caviness Distinguished Professor of Medicine at the UNC School of Medicine and director of the North Carolina Translational and Clinical Sciences (NC TraCS) Institute housed at UNC-Chapel Hill.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

This nationwide clinical trial funded through the National Institutes of Health including participation from patients at the UNC Diabetes Center, led by John Buse, MD, PhD. A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective at maintaining blood glucose (sugar) levels within normal range than standard-of-care … Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":34408,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[96,2],"tags":[631],"class_list":["post-61483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endocrinology-metabolism","category-news","tag-631","odd"],"acf":[],"yoast_head":"\nBionic Pancreas Improves Type 1 Diabetes Management Compared to Standard Insulin Delivery Methods | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/bionic-pancreas-improves-type-1-diabetes-management-compared-to-standard-insulin-delivery-methods\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bionic Pancreas Improves Type 1 Diabetes Management Compared to Standard Insulin Delivery Methods | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"This nationwide clinical trial funded through the National Institutes of Health including participation from patients at the UNC Diabetes Center, led by John Buse, MD, PhD. 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