{"id":62769,"date":"2023-01-09T16:46:40","date_gmt":"2023-01-09T21:46:40","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=62769"},"modified":"2023-06-06T18:23:28","modified_gmt":"2023-06-06T22:23:28","slug":"getting-to-the-heart-of-chemotherapeutic-cardiotoxicity","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/getting-to-the-heart-of-chemotherapeutic-cardiotoxicity\/","title":{"rendered":"Getting to the Heart of Chemotherapeutic Cardiotoxicity"},"content":{"rendered":"<p><em>Brian C. Jensen, associate professor of medicine and pharmacology in the Department of Medicine\u2019s Division of Cardiology, speaks about his research on kinase inhibitor cardiotoxicity.<\/em><\/p>\n<hr \/>\n<figure id=\"attachment_3728\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><a href=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3728\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834-300x230.jpeg\" alt=\"\" width=\"300\" height=\"230\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834-300x230.jpeg 300w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834-600x460.jpeg 600w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834-301x231.jpeg 301w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834.jpeg 652w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"caption wp-caption-text\">Brian Jensen, MD<\/figcaption><\/figure>\n<p>On any given Tuesday, you will find <a href=\"https:\/\/www.med.unc.edu\/medicine\/directory\/brian-jensen\/\">Brian C. Jensen, MD<\/a>, cardiologist and physician-scientist, tending to patients in his cardio-oncology clinic. His schedule is packed to the brim with cancer patients. But not patients with heart cancer.<\/p>\n<p>The largest number of patients he sees are cancer patients who have developed, or are at risk of developing, heart damage in response to their chemotherapy regimens. This type of heart damage, called cardiotoxicity, is a major cause of drug failure along different stages of drug development.<\/p>\n<p>Jensen, who came to the <a href=\"https:\/\/www.med.unc.edu\/\">UNC School of Medicine<\/a> in 2009, started the clinic in 2015 to help patients in a challenging situation.<\/p>\n<p>\u201cI started the cardio-oncology clinic because I recognized that patients who experience cardiovascular issues while receiving cancer treatment face a very challenging situation and I wanted to help them,\u201d said Jensen, who is an associate professor of medicine and pharmacology in the <a href=\"https:\/\/www.med.unc.edu\/medicine\/\">Department of Medicine<\/a>\u2019s <a href=\"https:\/\/www.med.unc.edu\/medicine\/cardiology\/\">Division of Cardiology<\/a>. \u201cMy investigative focus on cardio-oncology arose from a clinical observation, when I took care of a patient who had developed cardiotoxicity after being treated with a kinase inhibitor that I had been studying in my lab for years as part of another project.\u201d<\/p>\n<p>Kinases are proteins that aid in the transfer of a certain molecular group \u2013 called phosphates \u2013 to other proteins to alter their activity, stabilize them, or mark them for destruction. Many of these molecules control critical cellular process throughout our body such as cellular division, cellular signaling, and mediating numerous important functions in the heart.<\/p>\n<p><a href=\"https:\/\/news.unchealthcare.org\/2023\/01\/getting-to-the-heart-of-chemotherapeutic-cardiotoxicity\/\">Read More at UNC Health Newsroom<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brian C. Jensen, associate professor of medicine and pharmacology in the Department of Medicine\u2019s Division of Cardiology, speaks about his research on kinase inhibitor cardiotoxicity. On any given Tuesday, you will find Brian C. Jensen, MD, cardiologist and physician-scientist, tending to patients in his cardio-oncology clinic. His schedule is packed to the brim with cancer &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/getting-to-the-heart-of-chemotherapeutic-cardiotoxicity\/\" aria-label=\"Read more about Getting to the Heart of Chemotherapeutic Cardiotoxicity\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":3728,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[86,2],"tags":[632],"class_list":["post-62769","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiology","category-news","tag-632","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Getting to the Heart of Chemotherapeutic Cardiotoxicity | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/getting-to-the-heart-of-chemotherapeutic-cardiotoxicity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Getting to the Heart of Chemotherapeutic Cardiotoxicity | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Brian C. Jensen, associate professor of medicine and pharmacology in the Department of Medicine\u2019s Division of Cardiology, speaks about his research on kinase inhibitor cardiotoxicity. On any given Tuesday, you will find Brian C. Jensen, MD, cardiologist and physician-scientist, tending to patients in his cardio-oncology clinic. His schedule is packed to the brim with cancer &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/getting-to-the-heart-of-chemotherapeutic-cardiotoxicity\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-09T21:46:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-06T22:23:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/brian_jensen_whitehead-e1673300631834.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"652\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Morgan Duerden\" \/>\n<meta name=\"twitter:card\" 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