{"id":64969,"date":"2023-07-07T15:14:33","date_gmt":"2023-07-07T19:14:33","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=64969"},"modified":"2023-07-07T15:14:47","modified_gmt":"2023-07-07T19:14:47","slug":"higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss\/","title":{"rendered":"Higher Doses of Oral Semaglutide Improves Blood Sugar Control and Weight Loss"},"content":{"rendered":"<p><em>A multicenter, randomized, phase 3b trial, done in collaboration with a UNC School of Medicine researcher, found that once-daily oral semaglutide taken at higher doses of 25mg and 50mg improved regulation of blood sugar levels and weight loss compared to the standard 14 mg dose.<\/em><\/p>\n<hr \/>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-34408 alignright\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/10\/john-buse-podcast-e1612285894585.jpg\" alt=\"john-buse\" width=\"245\" height=\"252\" \/><\/p>\n<p>Diabetes is a progressive disease that affects one\u2019s ability to control blood sugar levels. For many patients, the condition becomes more severe over time and blood sugar levels grow more difficult to manage. Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, have granted patients more control in lowering of blood sugar.<\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/medicine\/endocrinology-metabolism\/people\/john-buse-md-phd\/\">John Buse, MD, PhD<\/a>, the Verne S. Caviness Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism, and an international team of researchers have presented new findings about new higher-dose formulations of oral semaglutide. Their study, which <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(23)01127-3\/fulltext\">was published<\/a> in <em>The Lancet<\/em>, found that once-daily oral semaglutide taken at 25 milligrams (mg) and 50 mg did a better job in lowering blood sugar levels and promoting weight loss than the lowest dose of 14 mg.<\/p>\n<p>\u201cLow doses of GLP-1 receptor agonists are really powerful for reducing A1C, or the average glucose in the blood,\u201d said Buse, who is also co-director of the <a href=\"https:\/\/tracs.unc.edu\/\">NC Translational and Clinical Sciences Institute<\/a>. \u201cWhereas, the higher doses that are really good for weight reduction. On average, patients lost eight kilograms (17.5 lbs) at 50 milligrams, which is nearly twice as much weight loss that we saw with the lowest dose.\u201d<\/p>\n<p><a href=\"https:\/\/news.unchealthcare.org\/2023\/06\/higher-doses-of-oral-semaglutide-increase-blood-sugar-control-and-weight-loss\">Read more on the SOM newsroom.\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A multicenter, randomized, phase 3b trial, done in collaboration with a UNC School of Medicine researcher, found that once-daily oral semaglutide taken at higher doses of 25mg and 50mg improved regulation of blood sugar levels and weight loss compared to the standard 14 mg dose. Diabetes is a progressive disease that affects one\u2019s ability to &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss\/\" aria-label=\"Read more about Higher Doses of Oral Semaglutide Improves Blood Sugar Control and Weight Loss\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":4367,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[96,2,92],"tags":[],"class_list":["post-64969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-endocrinology-metabolism","category-news","category-research","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Higher Doses of Oral Semaglutide Improves Blood Sugar Control and Weight Loss | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Higher Doses of Oral Semaglutide Improves Blood Sugar Control and Weight Loss | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"A multicenter, randomized, phase 3b trial, done in collaboration with a UNC School of Medicine researcher, found that once-daily oral semaglutide taken at higher doses of 25mg and 50mg improved regulation of blood sugar levels and weight loss compared to the standard 14 mg dose. Diabetes is a progressive disease that affects one\u2019s ability to &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-07T19:14:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-07T19:14:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/dr-john-buse-leads-clinical-trial-of-new-diabetes-treatment-image2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1306\" \/>\n\t<meta property=\"og:image:height\" content=\"868\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Morgan Duerden\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgan Duerden\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/higher-doses-of-oral-semaglutide-improves-blood-sugar-control-and-weight-loss\/\"},\"author\":{\"name\":\"Morgan 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