{"id":66202,"date":"2023-11-27T12:36:00","date_gmt":"2023-11-27T17:36:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=66202"},"modified":"2023-11-27T12:36:25","modified_gmt":"2023-11-27T17:36:25","slug":"novel-study-finds-aspirin-free-regimen-benefits-patients-with-lvad","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/novel-study-finds-aspirin-free-regimen-benefits-patients-with-lvad\/","title":{"rendered":"Novel study finds aspirin-free regimen benefits patients with LVAD"},"content":{"rendered":"

The ARIES-HM3 Randomized Clinical Trial assessed the safety and efficacy of excluding aspirin from the antithrombotic regimen in patients with advanced heart failure who have undergone implantation of a fully magnetically levitated left ventricular assist device (LVAD).<\/p>\n

\"\"<\/p>\n

\u201cThere has been no consensus in the field about use of or dose of aspirin in the LVAD population until this study. We can now safely say that not giving aspirin is not only safe from a thromboembolic risk profile but results in improved adverse event rate by a significant reduction in non-surgical bleeding which is a well-known complication related to LVAD therapy. Improving not only longevity but also reducing morbidity and improving quality of life is a big focus in the field of MCS,\u201d Mirnela Byku, MD, PhD, MBA,<\/a> co-author of the study and director of the\u00a0UNC Durable Mechanical Circulatory Device Program\u00a0said.<\/p>\n

The international clinical trial followed a randomized, double-blind, placebo-controlled design and involved 628 patients across 51 centers in 9 countries. The patients were divided into two groups: one receiving aspirin (100mg\/d) and the other receiving a placebo in addition to vitamin K antagonist (VKA) therapy. A focus was to determine if the likelihood a patient experiences major nonsurgical hemocompatibility-related adverse events (such as stroke, pump thrombosis, major bleeding, or arterial peripheral thromboembolism) within 12 months differed between the two groups.<\/p>\n

The results showed not giving aspirin to patients with advanced heart failure, treated with a fully magnetically levitated LVAD who are receiving VKAs, did not make their survival worse. Furthermore, aspirin avoidance was associated with a significant reduction (34%) in major nonsurgical bleeding events.<\/p>\n

The paper, \u201cAspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure<\/a>\u201d was published in JAMA.<\/p>\n","protected":false},"excerpt":{"rendered":"

The ARIES-HM3 Randomized Clinical Trial assessed the safety and efficacy of excluding aspirin from the antithrombotic regimen in patients with advanced heart failure who have undergone implantation of a fully magnetically levitated left ventricular assist device (LVAD). \u201cThere has been no consensus in the field about use of or dose of aspirin in the LVAD … Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":3663,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[86,2,583],"tags":[632],"class_list":["post-66202","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiology","category-news","category-research-news","tag-632","odd"],"acf":[],"yoast_head":"\nNovel study finds aspirin-free regimen benefits patients with LVAD 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