{"id":66905,"date":"2024-02-14T15:12:02","date_gmt":"2024-02-14T20:12:02","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=66905"},"modified":"2024-02-14T15:12:02","modified_gmt":"2024-02-14T20:12:02","slug":"new-trial-highlights-incremental-progress-towards-a-cure-for-hiv-1","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/new-trial-highlights-incremental-progress-towards-a-cure-for-hiv-1\/","title":{"rendered":"New Trial Highlights Incremental Progress Towards a Cure for HIV-1"},"content":{"rendered":"

Cynthia L. Gay, MD, MPH, associate professor of infectious diseases, and David Margolis, MD, the Sarah Kenan Distinguished Professor of Medicine, Microbiology & Immunology, and Epidemiology in the UNC School of Medicine, published results of a clinical trial showing that vorinostat and immunotherapy may modestly shrink the latent HIV reservoir.<\/em><\/p>\n

\n
\"Cindy
Cindy Gay, MD, MPH<\/figcaption><\/figure>\n

Antiretroviral therapies (ART) stop HIV replication in its tracks, allowing people with HIV to live relatively normal lives. However, despite these treatments, some HIV still lingers inside cells in a dormant state known as \u201clatency.\u201d If ART is discontinued, HIV will awaken from its dormant state, begin to replicate, and cause acquired immunodeficiency syndrome (AIDS). To create a cure, researchers have been attempting to drive HIV out of latency and<\/em> target it for destruction.<\/p>\n

A new clinical trial led by Cynthia Gay, MD, MPH<\/a>, associate professor of infectious diseases, David Margolis, MD<\/a>, the Sarah Kenan Distinguished Professor of Medicine, Microbiology & Immunology, and Epidemiology, and other clinicians and researchers at the UNC School of Medicine suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them.<\/p>\n

The immunotherapy was provided by a team led by Catherine Bollard, MD, at the George Washington University, who took white blood cells from the study participants and expanded them in the laboratory, augmenting the cells\u2019 ability to attack HIV-infected cells, before re-infusion at UNC.<\/p>\n

Their results, published in<\/a> the Journal of Infectious Diseases<\/em>, showed a small dent on the latent reservoir, demonstrating that there is more work to be done in the field.<\/p>\n

\u201cWe did show that this approach can reduce the reservoir, but the reductions were not nearly large enough, and statistically speaking were what we call a \u201ctrend\u201d but not highly statistically significant,\u201d said David Margolis, MD<\/a>, director of the HIV Cure Center<\/a> and senior author on the paper. \u201cWe need to create better approaches to flush out the virus and attack it when it comes out. We need to keep chipping away at the reservoir until there\u2019s nothing there.\u201d<\/p>\n

Read more on the UNC Health Newsroom.\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Cynthia L. Gay, MD, MPH, associate professor of infectious diseases, and David Margolis, MD, the Sarah Kenan Distinguished Professor of Medicine, Microbiology & Immunology, and Epidemiology in the UNC School of Medicine, published results of a clinical trial showing that vorinostat and immunotherapy may modestly shrink the latent HIV reservoir. Antiretroviral therapies (ART) stop HIV … Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":51176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[100,2,583],"tags":[673],"class_list":["post-66905","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infectious-diseases","category-news","category-research-news","tag-673","odd"],"acf":[],"yoast_head":"\nNew Trial Highlights Incremental Progress Towards a Cure for HIV-1 | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/new-trial-highlights-incremental-progress-towards-a-cure-for-hiv-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Trial Highlights Incremental Progress Towards a Cure for HIV-1 | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Cynthia L. Gay, MD, MPH, associate professor of infectious diseases, and David Margolis, MD, the Sarah Kenan Distinguished Professor of Medicine, Microbiology & Immunology, and Epidemiology in the UNC School of Medicine, published results of a clinical trial showing that vorinostat and immunotherapy may modestly shrink the latent HIV reservoir. 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