{"id":66957,"date":"2024-02-22T12:10:51","date_gmt":"2024-02-22T17:10:51","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=66957"},"modified":"2024-02-22T12:13:49","modified_gmt":"2024-02-22T17:13:49","slug":"jensen-receives-1-4m-to-study","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/","title":{"rendered":"Jensen Receives $1.4M to Study How MEK and Drugs that Inhibit MEK Affect Mitochondria in Heart Muscle and Breast Cancer Cells"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-66744 alignright\" src=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-1024x943.jpg\" alt=\"\" width=\"300\" height=\"276\" srcset=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-1024x943.jpg 1024w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-300x276.jpg 300w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-768x707.jpg 768w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-1536x1414.jpg 1536w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-600x552.jpg 600w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped-301x277.jpg 301w, https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped.jpg 1887w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Brian Jensen, MD, PI, received a R01, $1.4M direct, grant from the NIH&#8217;s National Heart, Lung, and Blood Institute. The researches will investigate how MEK (Mitogen-Activated Protein Kinase Kinase) and drugs that inhibit MEK affect mitochondria within two types of cells: cardiomyocytes (heart muscle cells) and triple-negative breast cancer cells. This study aims to understand the role of MEK and its inhibitors on cellular energy production, survival, and function, particularly focusing on how these interactions may influence heart health and cancer treatment. Co-investigators include William Kim, MD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brian Jensen, MD, PI, received a R01, $1.4M direct, grant from the NIH&#8217;s National Heart, Lung, and Blood Institute. The researches will investigate how MEK (Mitogen-Activated Protein Kinase Kinase) and drugs that inhibit MEK affect mitochondria within two types of cells: cardiomyocytes (heart muscle cells) and triple-negative breast cancer cells. This study aims to understand &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\" aria-label=\"Read more about Jensen Receives $1.4M to Study How MEK and Drugs that Inhibit MEK Affect Mitochondria in Heart Muscle and Breast Cancer Cells\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":66744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[86,2],"tags":[673],"class_list":["post-66957","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiology","category-news","tag-673","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jensen Receives $1.4M to Study How MEK and Drugs that Inhibit MEK Affect Mitochondria in Heart Muscle and Breast Cancer Cells | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jensen Receives $1.4M to Study How MEK and Drugs that Inhibit MEK Affect Mitochondria in Heart Muscle and Breast Cancer Cells | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Brian Jensen, MD, PI, received a R01, $1.4M direct, grant from the NIH&#8217;s National Heart, Lung, and Blood Institute. The researches will investigate how MEK (Mitogen-Activated Protein Kinase Kinase) and drugs that inhibit MEK affect mitochondria within two types of cells: cardiomyocytes (heart muscle cells) and triple-negative breast cancer cells. This study aims to understand &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2024-02-22T17:10:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-22T17:13:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1887\" \/>\n\t<meta property=\"og:image:height\" content=\"1737\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Morgan Duerden\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgan Duerden\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\"},\"author\":{\"name\":\"Morgan Duerden\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#\/schema\/person\/99bd6d3f6c7b07d9e318254957f14bf9\"},\"headline\":\"Jensen Receives $1.4M to Study How MEK and Drugs that Inhibit MEK Affect Mitochondria in Heart Muscle and Breast Cancer Cells\",\"datePublished\":\"2024-02-22T17:10:51+00:00\",\"dateModified\":\"2024-02-22T17:13:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\"},\"wordCount\":109,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped.jpg\",\"keywords\":[\"2024\"],\"articleSection\":[\"Cardiology\",\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\",\"url\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\",\"name\":\"Jensen Receives $1.4M to Study How MEK and Drugs that Inhibit MEK Affect Mitochondria in Heart Muscle and Breast Cancer Cells | Department of Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped.jpg\",\"datePublished\":\"2024-02-22T17:10:51+00:00\",\"dateModified\":\"2024-02-22T17:13:49+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#\/schema\/person\/99bd6d3f6c7b07d9e318254957f14bf9\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/news\/jensen-receives-1-4m-to-study\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/01\/Photo-Jensen-2017-cropped.jpg\",\"width\":1887,\"height\":1737,\"caption\":\"UNC Department of Medicine, Chapel Hill, North Carolina. 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