{"id":67481,"date":"2024-05-19T13:00:30","date_gmt":"2024-05-19T17:00:30","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=67481"},"modified":"2024-05-22T13:00:44","modified_gmt":"2024-05-22T17:00:44","slug":"manuscript-co-authored-by-unc-hematology-researchers-accepted-in-blood-advances","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/manuscript-co-authored-by-unc-hematology-researchers-accepted-in-blood-advances\/","title":{"rendered":"Manuscript co-authored by UNC Hematology Researchers Accepted in Blood Advances"},"content":{"rendered":"<p>Nirupama Ramadas, PhD, Fatima Trebak, PhD, Rafal Pawlinski, PhD, and Erin Sparkenbaugh, PhD, with the UNC Division of Hematology, are co-authors of \u201cBiased agonism of protease-activated receptor-1 regulates thrombo-inflammation in murine sickle cell disease.&#8221; <a href=\"https:\/\/ashpublications.org\/bloodadvances\/article\/doi\/10.1182\/bloodadvances.2023011907\/515787\/Biased-agonism-of-protease-activated-receptor-1\">Their manuscript<\/a> was accepted in Blood Advances, a journal of the American Society of Hematology.<\/p>\n<p>The study shows APC inhibition exacerbates thrombin generation, inflammation and end-organ damage in a mouse model of sickle cell disease (SCD), and APC-PAR1 biased agonism reduces inflammation, suggesting that targeting this pathway may mitigate vascular complications of SCD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nirupama Ramadas, PhD, Fatima Trebak, PhD, Rafal Pawlinski, PhD, and Erin Sparkenbaugh, PhD, with the UNC Division of Hematology, are co-authors of \u201cBiased agonism of protease-activated receptor-1 regulates thrombo-inflammation in murine sickle cell disease.&#8221; Their manuscript was accepted in Blood Advances, a journal of the American Society of Hematology. The study shows APC inhibition exacerbates &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/manuscript-co-authored-by-unc-hematology-researchers-accepted-in-blood-advances\/\" aria-label=\"Read more about Manuscript co-authored by UNC Hematology Researchers Accepted in Blood Advances\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":67482,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[520,2,583],"tags":[],"class_list":["post-67481","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hematology","category-news","category-research-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Manuscript co-authored by UNC Hematology Researchers Accepted in Blood Advances | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/manuscript-co-authored-by-unc-hematology-researchers-accepted-in-blood-advances\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Manuscript co-authored by UNC Hematology Researchers Accepted in Blood Advances | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Nirupama Ramadas, PhD, Fatima Trebak, PhD, Rafal Pawlinski, PhD, and Erin Sparkenbaugh, PhD, with the UNC Division of Hematology, are co-authors of \u201cBiased agonism of protease-activated receptor-1 regulates thrombo-inflammation in murine sickle cell disease.&#8221; Their manuscript was accepted in Blood Advances, a journal of the American Society of Hematology. The study shows APC inhibition exacerbates &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/manuscript-co-authored-by-unc-hematology-researchers-accepted-in-blood-advances\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2024-05-19T17:00:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-22T17:00:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2024\/05\/ASH.png\" \/>\n\t<meta property=\"og:image:width\" content=\"224\" \/>\n\t<meta property=\"og:image:height\" content=\"225\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Morgan Duerden\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" 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