{"id":69910,"date":"2025-09-30T14:50:26","date_gmt":"2025-09-30T18:50:26","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=69910"},"modified":"2025-09-30T15:40:14","modified_gmt":"2025-09-30T19:40:14","slug":"evan-dellon-lead-phase-3-trial-on-cendakimab-for-eosinophilic-esophagitis","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/evan-dellon-lead-phase-3-trial-on-cendakimab-for-eosinophilic-esophagitis\/","title":{"rendered":"Evan Dellon Leads Phase 3 Trial on Cendakimab for Eosinophilic Esophagitis"},"content":{"rendered":"

\"\"Evan Dellon, MD, MPH, a Professor in the Division of Gastroenterology and Hepatology at UNC and the Director of the Center for Esophageal Diseases and Swallowing, led a Phase 3 Trial on using Cendakimab for Eosinophilic Esophagitis (EoE). His study was published in NEJM Evidence with positive findings.<\/span><\/p>\n

Cendakimab is a high-affinity monoclonal antibody that blocks IL-13 by preventing interaction with IL-13 receptors alpha-1 and alpha-2. In Dr. Dellons’ study, Cendakimab demonstrated statistically significant improvements in symptoms, histologic response, and endoscopic features of EoE as compared to the placebo group. The study involved over 400 participants across 15 countries.<\/p>\n

The study’s’ results suggest Cendakimab offers clinically meaningful improvements in symptoms, histology, and endoscopic outcomes for patients with EoE. Importantly, the tested therapy demonstrated a manageable safety profile, reinforcing IL-13 as a viable therapeutic target in type 2 inflammatory diseases.<\/p>\n

Read the full evidence report here.<\/a><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Evan Dellon, MD, MPH, a Professor in the Division of Gastroenterology and Hepatology at UNC and the Director of the Center for Esophageal Diseases and Swallowing, led a Phase 3 Trial on using Cendakimab for Eosinophilic Esophagitis (EoE). His study was published in NEJM Evidence with positive findings. Cendakimab is a high-affinity monoclonal antibody that … Read more<\/a><\/p>\n","protected":false},"author":116983,"featured_media":69756,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[97,2,92,583],"tags":[],"class_list":["post-69910","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gastroenterology","category-news","category-research","category-research-news","odd"],"acf":[],"yoast_head":"\nEvan Dellon Leads Phase 3 Trial on Cendakimab for Eosinophilic Esophagitis | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/evan-dellon-lead-phase-3-trial-on-cendakimab-for-eosinophilic-esophagitis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evan Dellon Leads Phase 3 Trial on Cendakimab for Eosinophilic Esophagitis | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Evan Dellon, MD, MPH, a Professor in the Division of Gastroenterology and Hepatology at UNC and the Director of the Center for Esophageal Diseases and Swallowing, led a Phase 3 Trial on using Cendakimab for Eosinophilic Esophagitis (EoE). His study was published in NEJM Evidence with positive findings. 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