{"id":70266,"date":"2026-01-20T10:11:09","date_gmt":"2026-01-20T15:11:09","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=70266"},"modified":"2026-01-20T10:12:00","modified_gmt":"2026-01-20T15:12:00","slug":"new-once-weekly-investigational-oral-regimen-shows-strong-48-week-results-highlighting-the-need-for-easier-hiv-treatment-options","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/new-once-weekly-investigational-oral-regimen-shows-strong-48-week-results-highlighting-the-need-for-easier-hiv-treatment-options\/","title":{"rendered":"New Once Weekly Investigational Oral Regimen Shows Strong 48 Week Results, Highlighting the Need for Easier HIV Treatment Options"},"content":{"rendered":"<p>A Phase 2 study led by Dr. <a href=\"https:\/\/globalhealth.unc.edu\/people\/joseph-eron-md\/\">Joe Eron<\/a>, chief of the Division of Infectious diseases and a member of the UNC Institute for Global Health and Infectious Diseases (IGHID), shows an investigational once\u2011weekly, all\u2011oral combination of <a href=\"https:\/\/clinicalinfo.hiv.gov\/en\/drugs\/islatravir\/patient\">islatravir<\/a> (ISL) and <a href=\"https:\/\/clinicalinfo.hiv.gov\/en\/drugs\/lenacapavir\/patient\">lenacapavir<\/a>(LEN) maintains high levels of virologic suppression through 48 weeks in adults living with HIV. Published in the <a href=\"https:\/\/www.acpjournals.org\/doi\/10.7326\/ANNALS-25-01939\">Annals of Internal Medicine<\/a>, the findings underscore a growing priority in HIV care: expanding access to simpler, more flexible treatment options that fit the realities of people\u2019s lives.<\/p>\n<figure id=\"attachment_6892\" class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-6892\" src=\"https:\/\/globalhealth.unc.edu\/wp-content\/uploads\/sites\/1109\/2020\/03\/joe-eron-image-e1658875277268-259x300.png\" alt=\"joe-eron-investigational ISL+LEN regimen\" width=\"259\" height=\"300\" \/><figcaption class=\"caption wp-caption-text\">Joe Eron<\/figcaption><\/figure>\n<p>For many people living with HIV, daily medication is effective but not always easy. Stigma, pill fatigue, and the day\u2011to\u2011day demands of life can make strict adherence challenging. Missed doses can increase the risk of viral rebound and drug resistance, making the need for alternative dosing schedules more important than ever. The investigational ISL+LEN regimen\u2014taken once weekly\u2014has the potential to address these challenges by reducing dosing frequency while maintaining strong antiviral activity.<\/p>\n<p>Dr. Eron, the UNC Herman and Louise Smith Distinguished Professor of Medicine, emphasized the importance of broadening treatment choices.<\/p>\n<blockquote><p>\u201cPeople living with HIV deserve options that work not only medically, but practically. Daily pills are effective, but they\u2019re not the right fit for everyone. Seeing such strong suppression with a once\u2011weekly regimen is incredibly encouraging. It suggests we may be able to offer patients a simpler approach that still delivers the control they need.\u201d<\/p><\/blockquote>\n<p>Read more details regarding the study on the <a href=\"https:\/\/globalhealth.unc.edu\/2026\/01\/new-once-weekly-investigational-oral-regimen-shows-strong-48-week-results-highlighting-the-need-for-easier-hiv-treatment-options\/\">IGHID website.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A Phase 2 study led by Dr. Joe Eron, chief of the Division of Infectious diseases and a member of the UNC Institute for Global Health and Infectious Diseases (IGHID), shows an investigational once\u2011weekly, all\u2011oral combination of islatravir (ISL) and lenacapavir(LEN) maintains high levels of virologic suppression through 48 weeks in adults living with HIV. &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/new-once-weekly-investigational-oral-regimen-shows-strong-48-week-results-highlighting-the-need-for-easier-hiv-treatment-options\/\" aria-label=\"Read more about New Once Weekly Investigational Oral Regimen Shows Strong 48 Week Results, Highlighting the Need for Easier HIV Treatment Options\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[100,2,92,583],"tags":[],"class_list":["post-70266","post","type-post","status-publish","format-standard","hentry","category-infectious-diseases","category-news","category-research","category-research-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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