{"id":70366,"date":"2026-02-26T11:43:45","date_gmt":"2026-02-26T16:43:45","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/?p=70366"},"modified":"2026-02-26T11:44:32","modified_gmt":"2026-02-26T16:44:32","slug":"unc-researchers-reveal-mechanisms-driving-alpha-gal-syndrome-allergic-reactions","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/medicine\/news\/unc-researchers-reveal-mechanisms-driving-alpha-gal-syndrome-allergic-reactions\/","title":{"rendered":"UNC Researchers Reveal Mechanisms Driving Alpha-Gal Syndrome Allergic Reactions"},"content":{"rendered":"<p><span class=\"Apple-converted-space\">A<\/span>\u00a0study co-authored by Onyinye I. Iweala, MD, PhD, of the UNC Division of Rheumatology, Allergy, and Immunology and the UNC Food Allergy Initiative has been accepted for publication in the <i>Journal of Allergy and Clinical Immunology<\/i>. The study found that select alpha-gal-specific human immunoglobulin E (IgE) clones can promote both alpha-gal-dependent and antigen-independent allergic effector cell activation.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>The study, titled <b>\u201c<\/b>Alpha-gal-specific human IgE promotes both alpha-gal-induced and antigen-independent allergic effector cell activation,<b>\u201d <\/b>evaluated whether alpha-gal-specific immunoglobulin E (IgE), independent of other blood proteins, is sufficient to activate allergic effector cells. Using CRISPR technology, researchers generated an alpha-gal\u2013deficient RBL cell line expressing human IgE receptors. Cells passively sensitized with sera from patients with alpha-gal syndrome or with select alpha-gal-specific human IgE clones demonstrated both alpha-gal-dependent and antigen-independent activation, as assessed by CD63 expression and mediator release assays.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>These findings are groundbreaking, as the prevalence of alpha-gal was found to have risen over 5,500% since 2020 <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12365936\/\">in a recent report.<\/a> Scott P. Commins, MD, PhD, a contributing author, also reported that 96,000\u2013450,000 persons in the United States might have been affected by Alpha Gal Syndrome since 2010.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>The research team included Yinghui Wang, MBBS, MS; Yugen Zhang, DVM, PhD; Scott P. Commins, MD, PhD; and colleagues from the UNC Division of Rheumatology, Allergy, and Immunology, the Thurston Arthritis Research Center, and collaborating institutions.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.jacionline.org\/article\/S0091-6749(26)00001-1\/fulltext\">Read the full publication on the journal&#8217;s website.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0study co-authored by Onyinye I. Iweala, MD, PhD, of the UNC Division of Rheumatology, Allergy, and Immunology and the UNC Food Allergy Initiative has been accepted for publication in the Journal of Allergy and Clinical Immunology. The study found that select alpha-gal-specific human immunoglobulin E (IgE) clones can promote both alpha-gal-dependent and antigen-independent allergic effector &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/news\/unc-researchers-reveal-mechanisms-driving-alpha-gal-syndrome-allergic-reactions\/\" aria-label=\"Read more about UNC Researchers Reveal Mechanisms Driving Alpha-Gal Syndrome Allergic Reactions\">Read more<\/a><\/p>\n","protected":false},"author":112673,"featured_media":4519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-70366","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC Researchers Reveal Mechanisms Driving Alpha-Gal Syndrome Allergic Reactions | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/news\/unc-researchers-reveal-mechanisms-driving-alpha-gal-syndrome-allergic-reactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC Researchers Reveal Mechanisms Driving Alpha-Gal Syndrome Allergic Reactions | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"A\u00a0study co-authored by Onyinye I. Iweala, MD, PhD, of the UNC Division of Rheumatology, Allergy, and Immunology and the UNC Food Allergy Initiative has been accepted for publication in the Journal of Allergy and Clinical Immunology. The study found that select alpha-gal-specific human immunoglobulin E (IgE) clones can promote both alpha-gal-dependent and antigen-independent allergic effector &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/news\/unc-researchers-reveal-mechanisms-driving-alpha-gal-syndrome-allergic-reactions\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-26T16:43:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-26T16:44:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/medicine\/wp-content\/uploads\/sites\/945\/2018\/12\/unc-researcher-responsible-for-discovering-an-allergy-linked-to-tick-bites-image2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"522\" \/>\n\t<meta property=\"og:image:height\" content=\"574\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Morgan Duerden\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Morgan Duerden\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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