{"id":22897,"date":"2017-10-10T14:00:00","date_gmt":"2017-10-04T21:11:22","guid":{"rendered":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/"},"modified":"2019-03-07T13:58:28","modified_gmt":"2019-03-07T18:58:28","slug":"mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits","status":"publish","type":"tribe_events","link":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/","title":{"rendered":"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits"},"content":{"rendered":"<div>\n<p>Speaker: Kari North, PhD<br \/>Topic: Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits<\/p>\n<p>Presentation Preview: <em>Genome-wide association studies (GWAS) have laid the foundation for many downstream investigations, including the biology of complex traits, drug development, and clinical guidelines. However, the dominance of European-ancestry populations in GWAS creates a biased view of human variation and hinders the translation of genetic associations into clinical and public health applications. To demonstrate the benefit of studying underrepresented populations, the Population Architecture using Genomics and Epidemiology (PAGE) study conducted a GWAS of 26 clinical and behavioral phenotypes in 49,839 non-European individuals. Using novel strategies for multi-ethnic analysis of admixed populations, we confirm 574 GWAS catalog variants across these traits, and find 28 novel loci and 42 residual signals in known loci. Our data show strong evidence of effect-size heterogeneity across ancestries for published GWAS associations, which substantially restricts genetically-guided precision medicine. We advocate for new, large genome-wide efforts in diverse populations to reduce health disparities.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Speaker: Kari North, PhDTopic: Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits Presentation Preview: Genome-wide association studies (GWAS) have laid the foundation for many downstream investigations, including the biology of complex traits, drug development, and clinical guidelines. However, the dominance of European-ancestry populations in GWAS creates a biased view of human &hellip; <a href=\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/\" aria-label=\"Read more about MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits\">Read more<\/a><\/p>\n","protected":false},"author":45695,"featured_media":0,"template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","_links_to":"","_links_to_target":""},"tags":[67],"tribe_events_cat":[95],"class_list":["post-22897","tribe_events","type-tribe_events","status-publish","hentry","tag-67","tribe_events_cat-grand-rounds","cat_grand-rounds","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits | Department of Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits | Department of Medicine\" \/>\n<meta property=\"og:description\" content=\"Speaker: Kari North, PhDTopic: Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits Presentation Preview: Genome-wide association studies (GWAS) have laid the foundation for many downstream investigations, including the biology of complex traits, drug development, and clinical guidelines. However, the dominance of European-ancestry populations in GWAS creates a biased view of human &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Medicine\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCDeptMedicine\" \/>\n<meta property=\"article:modified_time\" content=\"2019-03-07T18:58:28+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@uncdeptmedicine\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/\",\"url\":\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/\",\"name\":\"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits | Department of Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#website\"},\"datePublished\":\"2017-10-04T21:11:22+00:00\",\"dateModified\":\"2019-03-07T18:58:28+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/medicine\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Events\",\"item\":\"https:\/\/www.med.unc.edu\/medicine\/events\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/medicine\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/medicine\/\",\"name\":\"Department of Medicine\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/medicine\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits | Department of Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/","og_locale":"en_US","og_type":"article","og_title":"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits | Department of Medicine","og_description":"Speaker: Kari North, PhDTopic: Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits Presentation Preview: Genome-wide association studies (GWAS) have laid the foundation for many downstream investigations, including the biology of complex traits, drug development, and clinical guidelines. However, the dominance of European-ancestry populations in GWAS creates a biased view of human &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/","og_site_name":"Department of Medicine","article_publisher":"https:\/\/www.facebook.com\/UNCDeptMedicine","article_modified_time":"2019-03-07T18:58:28+00:00","twitter_card":"summary_large_image","twitter_site":"@uncdeptmedicine","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/","url":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/","name":"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits | Department of Medicine","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/medicine\/#website"},"datePublished":"2017-10-04T21:11:22+00:00","dateModified":"2019-03-07T18:58:28+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/medicine\/event\/mhi-seminar-series-kari-north-phd-genetic-diversity-turns-a-new-page-in-our-understanding-of-complex-traits\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/medicine\/"},{"@type":"ListItem","position":2,"name":"Events","item":"https:\/\/www.med.unc.edu\/medicine\/events\/"},{"@type":"ListItem","position":3,"name":"MHI Seminar Series: Kari North, PhD, Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/medicine\/#website","url":"https:\/\/www.med.unc.edu\/medicine\/","name":"Department of Medicine","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/medicine\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/tribe_events\/22897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/users\/45695"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/tribe_events\/22897\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/media?parent=22897"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/tags?post=22897"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.med.unc.edu\/medicine\/wp-json\/wp\/v2\/tribe_events_cat?post=22897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}