MHI Seminar Series: Mingfu Wu, Ph.D., Associate Professor, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Texas
2024-03-20 10:00 - 11:00 (America/New_York) | Macnider Hall, Conference Room 321, 333 S. Columbia St., Chapel Hill, NC, 27514, United States

MHI SEMINAR SERIES: Jonathan Brown, M.D., Associate Professor, Medicine, Cardiovascular Medicine at Vanderbilt University
2024-04-17 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Jonathan Brown, MD, is a cardiologist and basic scientist studying transcriptional mechanisms relevant to the pathogenesis of obesity, diabetes mellitus, and atherosclerosis. A central premise of his research involves a deeper understanding of the gene regulatory networks controlling disease pathogenesis to identify novel therapeutic targets to treat these prevalent and often fatal conditions.
More specifically, Dr. Brown aims to study how chromatin regulators—as determinants of enhancer function and transcription—are involved in driving pathologic gene expression programs that alter vascular cell and adipose tissue function and result in cardiovascular disease and metabolic dysfunction. Because of his interest in the interplay among inflammation, metabolic disease, and atherogenesis, he is pursuing overlapping areas of investigation examining: how proinflammatory activation of vascular endothelium and macrophages drives enhancer remodeling and gene activation through the bromodomain and extra-terminal (BET) bromodomain proteins (BRD2, BRD3 and BRD4); and how BET proteins control adipocyte plasticity and differentiation relevant for obesity and systemic metabolic diseases.
Dr. Brown’s areas of expertise are general cardiology, preventive cardiology, and management of hyperlipidemia.

MHI Seminar Series: Jonathan Brown, M.D., Associate Professor of Medicine; Riven Family Director of Experimental Biology, Division of Cardiovascular Medicine, Vanderbilt University Medical Center
2024-04-17 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

Rong Wang, Ph.D., Professor of Surgery, Director, Laboratory for Accelerated Vascular Research, UCSF
2024-04-24 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Research Overview:

MOLECULAR PROGRAMMING OF THE VASCULATURE IN DEVELOPMENT AND DISEASE
Proper formation and function of the vasculature are crucial for health and survival, as the vasculature supplies all cells in the body. A dysfunctional vasculature causes myriad diseases, including stroke, arterial occlusive diseases, and vascular anomalies. Our long-term goal is to identify novel drug targets and inform rational therapeutic designs to treat vascular diseases. Our strategy is to understand genes crucial for angiogenesis (new vessel formation) in the normal and diseased states, concentrating on the Notch, ephrin-B2, and TGF- pathways. We employ cutting-edge mouse genetics to delete or express genes in a cell lineage-specific and temporally controllable fashion in vascular cells. We combine these molecular approaches with mouse models of diseases as well as live 5D two-photon imaging (3D + blood flow over time) to uncover both the molecular mechanisms and hemodynamic signals in development and disease progression. These preclinical animal studies are coupled with patient sample validations. Our lab members come from diverse fields, including biology, bioengineering, and medicine, creating a collaborative and exciting environment. We strive to advance multiple projects across disciplines.

MHI Seminar Series: Rong Wang, Ph.D., Professor, Surgery, Division of Vascular and Endovascular Surgery; Mildred V. Strouss Endowed Chair in Vascular Surgery; Director, Laboratory for Accelerated Vascular Research, University of California, San Francisco
2024-04-24 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI SEMINAR SERIES: Karen Hirschi, Ph.D., Professor, Cell Biology, Director, UVA Developmental Genomics Center, University of Virginia
2024-05-01 10:00 - 11:00 | 1131 Bioinformatics Building, 130 Mason Farm Rd., Chapel Hill, NC, 27514, United States
Research Interest: Our laboratory is specifically interested in the regulation of endothelial cell commitment, differentiation and cell cycle progression, and defining signaling pathways that modulate these processes. We also aim to understand how some endothelial cells acquire specialized functions, such as the generation and/or maintenance of multi-lineage stem/progenitor cells.

2024 Fall Seminar Series to Kick off in September
2024-09-18 10:00 - 11:00 | Lineberger Comprehensive Cancer Center, Pagano Conference Room 00-002, 450 West Dr., Chapel Hill, NC, 27599, United States
Yosuke Mukoyama, Ph.D.

Senior Investigator, Lab Stem Cell and Neurovascular Biology Cell and Developmental Biology Center, NHLBI/NHI, Bethesda, MD
The overarching goal of the Laboratory of Stem Cell and Neurovascular Research, led by Dr. Yosuke Mukoyama (Yoh‐suke Mukouyama in PubMed), is to uncover the molecular control of the morphologic processes underlying the branching morphogenesis and patterning of the vascular and nervous systems.

MHI Seminar Series: Yosuke Mukoyama, Ph.D. Senior Investigator, Lab Stem Cell and Neurovascular Biology Cell and Developmental Biology Center, NHLBI/NHI, Bethesda, MD
2024-09-18 10:00 - 11:00 | Lineberger Comprehensive Cancer Center, Pagano Conference Room 00-002, 450 West Dr., Chapel Hill, NC, 27599, United States

2024 Triangle Regeneration Biology Symposium
2024-10-01 10:00 - 18:00 | Trent Semans Center, Duke University, 8 Searle Center Dr., Durham, NC, 27710, United States

MHI Special Seminar: Jaap van Buul, Ph.D., Professor, Vascular Cell Biology Lab, Amsterdam University Medical Center, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
2024-10-07 14:30 - 15:30 | Lineberger Comprehensive Cancer Center, Pagano Conference Room 00-002, 450 West Dr., Chapel Hill, NC, 27599, United States

MHI Seminar Series: Stefania Nicoli, Ph.D., Associate Professor Tenure, MEDINT Cardiology, Yale University, New Haven, CT
2024-10-16 10:00 - 11:00 | Lineberger Comprehensive Cancer Center, Pagano Conference Room 00-002, 450 West Dr., Chapel Hill, NC, 27599, United States

MHI Seminar Series: Joshua D. Wythe, Ph.D., Associate Professor, Departments of Cell Biology & Neuroscience, University of Virginia School of Medicine
2024-11-13 10:00 - 11:00 | Lineberger Comprehensive Cancer Center, Pagano Conference Room 00-002, 450 West Dr., Chapel Hill, NC, 27599, United States

MHI Special Seminar: Francisco Laurindo, M.D., Ph.D., Professor & Director, Heart Institute Vascular Biology Lab, University of São Paolo, Brazil & President, Society for Redox Biology and Medicine
2024-11-19 12:30 - 13:30 | Marsico 2004, 125 Mason Farm Road, Chapel Hill, NC, 27514, United States

MHI Seminar Series: Jun Wang, Ph.D., Associate Professor, Departments of Pediatrics, The University of Texas Health Science Center at Houston
2024-12-04 10:00 - 11:00 | Lineberger Comprehensive Cancer Center, Pagano Conference Room 00-002, 450 West Dr., Chapel Hill, NC, 27599, United States

CANCELLED MHI Seminar Series: Karen Hirschi, Ph.D., Alumni Professor of Cell Biology, Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA
2025-02-11 09:33, 2025-05-22 10:00 - 11:00 | NC

2025 MHI/IVB Spring Research Symposium
2025-03-12 09:00 - 17:00 | The Carolina Club, George Watts Alumni Center, 150 Stadium Drive, Chapel Hill, NC, 27514

MHI Seminar Series: MHI Keynote Speaker -- Federica Accornero, Ph.D., Associate Professor, Molecular Biology, Cell Biology, and Biochemistry Brown University, Providence, RI
2025-03-12 15:00 - 16:00 | The Carolina Club, George Watts Alumni Center, 150 Stadium Drive, Chapel Hill, NC, 27514

MHI Seminar Series: Hanrui Zhang, Ph.D., Assistant Professor, Medicine/Cardiology, Columbia University, New York, NY
2025-03-26 10:00 - 11:00 | Bondurant Hall, Conference Room #G-100, 321 South Columbia St., Chapel Hill, NC, 27514, United States

MHI Special Seminar: Da-Zhi Wang, Ph.D., Professor, Internal Medicine and Molecular Pharmacology & Physiology; Endowed Chair of Cardiovascular Medicine; Director, Center for Regenerative Medicine, University of South Florida Health Heart Institute, Morsani College of Medicine, Tampa, FL
2025-03-28 10:00 - 11:00 | Marsico 2004, 125 Mason Farm Road, Chapel Hill, NC, 27514, United States

MHI Seminar Series: Michelle Ward, Ph.D., Assistant Professor, Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston
2025-04-09 10:00 - 11:00 | Bondurant Hall, Conference Room #G-100, 321 South Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Monica Lee, Ph.D., Assistant Professor, Physiology & Biophysics, University of Illinois-Chicago
2025-09-17 10:00 - 11:00 | Bondurant Hall, Conference Room #G-074, 321 S. Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Stephen Chang, M.D., Ph.D., Instructor, Internal Medicine-Cardiovascular and Biochemistry, Stanford University, School of Medicine, CA
2025-10-08 10:00 - 11:00 | Bondurant Hall, Conference Room #G-074, 321 S. Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Jinhu Wang, Ph.D., Assistant Professor, Division of Cardiology, Emory University School of Medicine, Atlanta, GA
2025-11-19 10:00 - 11:00 | Mary Ellen Jones, Conference Room 3116, 116 Manning Dr., Chapel Hill, NC, 27599, United States

MHI Seminar Series: Vasanth Vedantham, M.D., Ph.D., Professor, Medicine, University of California, San Francisco
2025-12-03 10:00 - 11:00 | Mary Ellen Jones, Conference Room 3116, 116 Manning Dr., Chapel Hill, NC, 27599, United States

MHI Seminar Series: Fabrizia Bonacina, Ph.D., Associate Professor, Department of Pharmacological and Biomolecular Science, University of Milan, Italy
2026-01-14 10:00 - 11:00 | MHI Zoom Virtual Seminar Room

MHI Seminar Series: Gabriele Schiattarella, M.D., Ph.D. Professor of Cardiometabolic Diseases Deutsches Herzzentrum der Charité (DHZC) – German Heart Center at Charité Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine (MDC), Helmholtz Association, Germany
2026-02-04 10:00 - 11:00 | MHI Zoom Virtual Seminar Room

2026 IVB/MHI Spring Research Symposium
2026-03-11 09:00 - 17:00 | The Carolina Club, George Watts Alumni Center, 150 Stadium Drive, Chapel Hill, NC, 27514

MHI Seminar Series: Rajan Jain, M.D., William Wikoff Smith Associate Professor, Dept of Medicine and Cell & Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
2026-03-11 15:00 - 16:00 | The Carolina Club, George Watts Alumni Center, 150 Stadium Drive, Chapel Hill, NC, 27514

MHI Seminar Series: Luisa Iruela-Arispe, Ph.D., Professor & Chair, Cell & Developmental Biology Department, Northwestern Feinberg School of Medicine, Chicago, IL
2026-04-15 10:00 - 11:00 | Marsico 2004, 125 Mason Farm Road, Chapel Hill, NC, 27514, United States
