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X-ORIGINAL-URL:https://www.med.unc.edu/mhi
X-WR-CALDESC:Events for UNC McAllister Heart Institute
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DTSTART;TZID=America/New_York:20180306T140000
DTEND;TZID=America/New_York:20180306T150000
DTSTAMP:20260618T051450
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SUMMARY:MHI Seminar Series: James F. Martin\, MD\, PhD\, “Hippo Signaling in Heart Regeneration”
DESCRIPTION:Speaker: James F. Martin\, MD\, PhD\, Vivian L. Smith Professor in Regenerative Medicine\, Baylor College of Medicine; Director\, Cardiomyocyte Renewal Lab\, Texas Heart Institute\nTopic: “Hippo Signaling in Heart Regeneration” \nSeminar Synopsis: Dr. Martin is an internationally recognized developmental and regenerative biologist who has made fundamental contributions to our understanding of development\, disease\, and regeneration. He has authored more than 135 peer-reviewed papers in top journals such as Nature\, Science\, Cell\, Developmental Cell\, Plos Genetics\, Development\, and PNAS. His recent groundbreaking work on the Hippo pathway in heart size regulation is a landmark study that led to the insight that the Hippo pathway is an inhibitor of adult heart muscle regeneration. Dr. Martin’s insights revealed new avenues for treatment of human heart failure. Dr. Martin has made fundamental insights into the role of the transcription factor Pitx2 in atrial fibrillation\, the most common sustained arrhythmia in the human population. He made use of the mouse model to investigate Pitx2 in atrial homeostasis but also in left right asymmetric morphogenesis that is essential for human development. Dr. Martin’s studies investigating Pitx2 function in craniofacial development provided insight into the molecular basis of Rieger syndrome. He uncovered a pivotal function for Bmp signaling in endothelial-mesenchymal transition and cardiac valve development. Dr. Martin’s studies uncovered a novel role for canonical Wnt signaling in cardiac progenitor cell diversification. He found the first microRNA implicated in orofacial clefting. Dr. Martin’s studies are highly cited and also reported on by the lay media.
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-james-f-martin-md-phd-hippo-signaling-in-heart-regeneration/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Dr. Frank Conlon":MAILTO:Frank_Conlon@med.unc.edu
GEO:35.9036242;-79.0508779
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DTSTART;TZID=America/New_York:20180313T090000
DTEND;TZID=America/New_York:20180313T170000
DTSTAMP:20260618T051450
CREATED:20180215T154343Z
LAST-MODIFIED:20180215T155250Z
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SUMMARY:2018 MHI/IVB Research Symposium
DESCRIPTION:UNC’s Integrative Vascular Biology (IVB) Training Program and the McAllister Heart Institute (MHI) jointly announce their Annual Research Symposium on Tuesday\, March 13\, 2018. This year’s event will be held from 9AM – 5PM at the George Watts Hill Alumni Center on the UNC campus (150 Stadium Drive\, Chapel Hill\, NC 27514). The symposium highlights research from graduate students\, postdocs\, and medical fellows within the cardiovascular community at UNC and the greater Chapel Hill area and promotes multi-disciplinary collaborative research in this important field. This year’s keynote speakers will be Caroline and Geoffrey Burns (Harvard University) who will jointly present a talk entitled “New insights into zebrafish cardiovascular development and regeneration” and Karen Hirschi (Yale University) who will present a talk entitled “Regulation of endothelial cell specification”. \nAbstract submission –  For those who wish to present data at the symposium\, the abstract submission deadline is Monday\, February 26th. Abstracts should include a title and all authors and are limited to 250 words (not including the title\, etc). Note that you will need to have your abstract on hand during the registration process\, and please indicate whether you wish to be considered for a limited number of oral presentations. Poster board dimensions are 3ft high by 4ft wide. For more information please contact Hannah Perrin (hjperrin@email.unc.edu). \nThe registration deadline for those not presenting is March 8th.
URL:https://www.med.unc.edu/mhi/event/2018-mhiivb-research-symposium/
LOCATION:George Watts Alumni Center\, 150 Stadium Drive\, Chapel Hill\, NC
ORGANIZER;CN="Diane Berlin":MAILTO:berlindm@email.unc.edu
GEO:35.9069652;-79.0458004
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DTSTART;TZID=America/New_York:20180320T140000
DTEND;TZID=America/New_York:20180320T150000
DTSTAMP:20260618T051450
CREATED:20180314T175620Z
LAST-MODIFIED:20180316T154213Z
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SUMMARY:MHI Seminar Series: Joan Taylor\, PhD\, "GRAFs mind the GAP between muscle fate and function"
DESCRIPTION:Speaker: Joan Taylor\, PhD\, Professor and Vice Chair for Research in Pathology and Lab Medicine\, UNC School of Medicine\nTopic: “GRAFs mind the GAP between muscle fate and function” \nSeminar Synopsis: The overall goal of our research is to characterize the intracellular signaling pathways that govern normal and aberrant growth responses in the cardiovascular and musculoskeletal system.  For this seminar\, I will focus on the role of GRAF family member RhoGAPs in muscle fate and function.  We originally identified GRAF1 (GTPase-regulator for RhoA associated with FAK) in an un-biased screen for Focal Adhesion Kinase binding partners and over the past several years we have shown that GRAF1 (Arhgap26) and it’s family members GRAF2 (Arhgap10) and -3 (Arhgap42) are critical for limiting RhoA activity in muscle (cardiac\, skeletal and smooth) wherein they play unique roles in co-regulating actin and membrane dynamics. In this seminar\, I will highlight our latest studies on GRAF3 which indicate a critical role for this protein in the development and pathogenesis of human hypertension. Moreover\, I will present new evidence to suggest that GRAF1 and GRAF2 may be equally as important for maintaining cardiac and skeletal muscle homeostasis respectively by novel mechanisms that involve mitochondrial quality control. Collectively\, our findings support the possibility that targeting GRAFs might provide promising therapeutic strategies to limit hypertension and striated muscle degeneration.
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-joan-taylor-phd-grafs-mind-the-gap-between-muscle-fate-and-function/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
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DTSTART;TZID=America/New_York:20180327T140000
DTEND;TZID=America/New_York:20180327T150000
DTSTAMP:20260618T051450
CREATED:20180314T181713Z
LAST-MODIFIED:20180314T184414Z
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SUMMARY:MHI Seminar Series: Kenneth Walsh\, PhD\, "Clonal Hematopoiesis and Cardiovascular Disease: New Mechanisms\, New Therapeutic Opportunities"
DESCRIPTION:Speaker: Lockhart B. McGuire Professor\, Director of Hematovascular Biology Center\, University of Virginia\nTopic: “Clonal Hematopoiesis and Cardiovascular Disease: New Mechanisms\, New Therapeutic Opportunities”
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-kenneth-walsh-phd/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Rosalind Coleman":MAILTO:rcoleman@unc.edu
GEO:35.9036242;-79.0508779
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