MHI Seminar Series: Kory Lavine, M.D., Ph.D., “Leveraging Cell Diversity in Cardiovascular Disease”
2020-02-19 10:00 - 11:00 (America/New_York) | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

2019 Yang Family Biomedical Scholars Lectures: Li Qian, Ph.D., "Programming And Reprogramming: What Does It Take To Make A Cardiomyocyte?"
2020-02-14 14:30 - 15:45 | 1131 Bioinformatics Building, 130 Mason Farm Rd., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Asa Gustafsson, Ph.D., “Mitochondrial Quality Control: The Difference Between Success and Failure”
2020-02-05 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Jacqueline H. Cole, Ph.D., “Osteovascular Structure and Function Following Ischemic Stroke”
2020-01-15 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Ying Zheng, Ph.D., “Organ-Specific Microvascular Engineering for Tissue Regeneration and Disease Modeling”
2019-12-04 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Joy Lincoln, Ph.D., “Developing mechanistic-based therapies in the treatment of calcific aortic valve disease”
2019-11-20 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: David Kass, M.D., “Leveraging Protein Kinase G to Treat Heart Disease”
2019-11-06 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

Hettleman TALKS, Featuring Li Qian, Ph.D. & Other Award Recipients
2019-11-04 16:00 - 18:00 | THE CAROLINA CLUB, ALUMNI HALL I AND II, 150 Stadium Dr., Chapel Hill, 27514, United States
Dr. Qian Presents “Following Tinman: A Journey To Mend A Broken Heart”

MHI Seminar Series: Brenda Ogle, Ph.D., “Cardiac Tissue Engineering: Bioprinting Strategies to Create Complex Cardiac Structures”
2019-10-30 10:00 - 11:00 | NC

MHI Seminar Series: Timothy A. McKinsey, Ph.D., “Epigenetic Therapies for Heart Failure”
2019-10-16 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Didier Stainier, Ph.D., Biological Robustness: Genetic Compensation and Transcriptional Adaptation
2019-10-03 11:00 - 12:00 | Bondurant Hall, Conference Room #G-100, 321 South Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Yuqing E. Chen, Ph.D., M.D., Advancing Lipid Gene Discoveries to Innovative Targets for Cardiovascular Disease
2019-09-25 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Kathy K. Griendling, PhD, Poldip2, Nox4 and Vascular Disease
2019-09-11 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Mugé N. Kuyumcu-Martinez, Rbfox2 regulated alternative splicing networks modulate Hippo signaling during cardiovascular development
2019-04-10 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Christopher Hughes, Ph.D
2019-04-03 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Christopher Hughes, Ph.D, Professor & Chair, Molecular Biology and Biochemistry, University of California, Irvine
Topic: Tissue engineering of functional vascular networks for organ-on-chip applications
Brief summary: The seminar will cover development of vascularized micro-organs (organ-on-chip technology), including brain, liver and tumors, and the potential for these in basic research, drug development/validation and personalized medicine.

MHI Seminar Series: Joyce Bischoff, Ph.D
2019-03-20 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Joyce Bischoff, Ph.D, Professor, Surgery/Vascular Biology Program, Boston Children’s Hospital/Harvard Medical School
Topic: Endothelial-to-Mesenchymal Transition in Mitral Valve Adaptation and Growth

MHI Seminar Series: Mugé N. Kuyumcu-Martinez, Ph.D
2019-03-06 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Mugé N. Kuyumcu-Martinez, Ph.D, Associate Professor, Dept. of Biochemistry & Molecular Biology, Dept. of Neuroscience, Cell Biology & Anatomy, University of Texas Medical Branch
Topic: Rbfox2 controls cardiovascular development via modulating Hippo signaling

IVB/MHI Annual Research Symposium
2019-03-05 09:00 - 17:00 | George Watts Alumni Center, 150 Stadium Drive, Chapel Hill, NC
UNC’s Integrative Vascular Biology (IVB) T32 Training Program and the McAllister Heart Institute (MHI) jointly announce their Annual Research Symposium on Tuesday, March 5th, 2019. This year’s event will be held from 9AM – 5PM at the George Watts Hill Alumni Center on the UNC campus (150 Stadium Drive, Chapel Hill, NC 27514). The symposium highlights research from graduate students, postdocs, and medical fellows within the cardiovascular community at UNC and the greater Chapel Hill area and promotes multi-disciplinary collaborative research in this important field. This year’s keynote speakers will be Lance L. Munn (Harvard) who uses biomedical engineering approaches to study blood vessel structure and function and Joseph A. Hill (UT Southwestern) whose research is focused on deciphering the mechanisms that control cardiac remodeling. Dr. Munn will present a talk entitled “Endothelial mechanobiology and morphogenesis” while Dr. Hill will present on “Heart failure: Two inflammatory tales”.
Registration and Abstract submission – Please register on-line at http://tinyurl.com/ya5wa7fz by Friday, March 1st. For those who wish to present data at the symposium, the abstract submission deadline is Monday, February 18th. Abstracts should include a title and all authors and are limited to 250 words (not including the title, etc). Note that you will need to have your abstract on hand during the registration process, and please indicate whether you wish to be considered for a limited number of oral presentations. Poster board dimensions are 3ft high by 4ft wide.
Symposium Social Event – All symposium attendees are invited to the on-site social event that begins at 4PM. We are including some games and prizes this year so we hope that everyone has a chance to stick around.
Please address questions to IVB Trainee, Ben Keepers (benjamin_keepers@med.unc.edu).

MHI Seminar Series: Elizabeth Murphy, Ph.D, "Novel mechanisms of cardioprotection"
2019-02-20 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Elizabeth Murphy, Ph.D, National Institutes of Health
Topic: Novel mechanisms of cardioprotection
Summary:
In the heart, interruption of the blood supply can result in cardiac cell death and irreversible muscle damage. Dr. Murphy’s laboratory studies the molecular mechanisms involved in cardiac cell death, as well as the mechanisms that protect the heart against damage. The knowledge gained from these studies may help identify novel therapies to reduce cardiac injury during ischemia and reperfusion. The current dogma suggests that calcium overload and reactive oxygen species generated during ischemia and heart failure lead to activation of a mitochondrial pore (mPTP) which initiates cell death. To better understand the regulation of the mPTP her lab has studied the mechanisms regulated by cyclophilin D, the only currently established member (albeit a regulator) of the mPTP. These studies demonstrated that cyclophilin D regulates mitochondrial acetylation (Nguyen et al Circ. Res, 2013). Collaborative studies with the Finkel laboratory leveraged recent advances identifying the mitochondrial transporter responsible for mitochondrial calcium uptake, which allowed for mechanistic studies of the role of calcium in activating cell death (Pan et al Nat Cell Biol, 2013).

MHI Seminar Series: Yoh-suke Mukouyama, Ph.D
2019-02-06 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Yoh-suke Mukouyama, Ph.D, National Institutes of Health
Topic:Macrophage control of neuronal and vascular development
Brief summary: Macrophages have diverse functions in immunity as well as in homeostasis, yet their functions during organ development remain largely undefined. Our work employs high-resolution whole-mount imaging and genetic tools to determine how embryonic tissue-resident macrophages influence neuronal and vascular development at single-cell resolution.

MHI Seminar Series: Young-sup Yoon, M.D., Ph.D
2019-01-23 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Young-sup Yoon, M.D., Ph.D, Emory University

MHI Seminar Series: Dr. Robert Wirka
2019-01-09 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Robert Wirka, Stanford University.
Topic: Single cell analysis of smooth muscle cell phenotypic modulation in vivo reveals a critical role for coronary disease gene TCF21 in mice and humans

MHI Seminar Series: Dr. Ann Murphy
2018-12-19 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Ann Murphy, Johns Hopkins University

MHI Seminar Series: Dr. Da-zhi Wang
2018-12-05 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Da-zhi Wang, Harvard University

MHI Seminar Series: Dr. Matthew C. Zimmerman
2018-11-28 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Matthew C Zimmerman, University of Nebraska Medical Center

MHI Seminar Series: Dr Matthias Nahrendorf
2018-11-07 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Matthias Nahrendorf, Professor, Center for Systems Biology, Harvard University
Topic: Myeloid Cells in Cardiovascular Disease

MHI Seminar Series: Dr. Bill Polacheck
2018-10-24 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States

MHI Seminar Series: Dr. Lena Claesson-Walsh
2018-10-12 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Lena Claesson-Walsh, Uppsala University

MHI Seminar Series: Dr. Brian Kim
2018-10-10 10:00 - 11:00 | 1131 Bioinformatics Building, 130 Mason Farm Rd., Chapel Hill, NC, 27514, United States
Speaker: Dr. Brian Kim, Stanford University

MHI Seminar Series: Dr. Anne Marie Schmidt, "Rage/Diaph1 Mechanism of Diabetic Complications and Metabolic Dysfunction"
2018-09-26 10:00 - 11:00 | 321 MacNider Hall, 333 S Columbia St., Chapel Hill, NC, 27514, United States
Speaker: Dr. Anne Marie Schmidt, New York University
Topic: Rage/Diaph1 Mechanism of Diabetic Complications and Metabolic Dysfunction
