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X-WR-CALDESC:Events for UNC McAllister Heart Institute
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240501T100000
DTEND;TZID=America/New_York:20240501T110000
DTSTAMP:20260415T204121
CREATED:20240123T195509Z
LAST-MODIFIED:20240202T143240Z
UID:10000227-1714557600-1714561200@www.med.unc.edu
SUMMARY:MHI SEMINAR SERIES: Karen Hirschi\, Ph.D.\, Professor\, Cell Biology\, Director\, UVA Developmental Genomics Center\, University of Virginia
DESCRIPTION:Research Interest: Our laboratory is specifically interested in the regulation of endothelial cell commitment\, differentiation and cell cycle progression\, and defining signaling pathways that modulate these processes. We also aim to understand how some endothelial cells acquire specialized functions\, such as the generation and/or maintenance of multi-lineage stem/progenitor cells.\n 
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-karen-hirschi-ph-d-professor-cell-biology-director-uva-developmental-genomics-center-university-of-virginia/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
CATEGORIES:Seminar Series
ORGANIZER;CN="Victoria Bautch":MAILTO:bautch@med.unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231206T100000
DTEND;TZID=America/New_York:20231206T110000
DTSTAMP:20260415T204121
CREATED:20231113T160301Z
LAST-MODIFIED:20240202T143522Z
UID:10000217-1701856800-1701860400@www.med.unc.edu
SUMMARY:MHI Seminar Series:  Walter Lee Murfee\, III\, Ph.D.\, “Rediscovering Angiogenesis at the Intersection of Tissue Engineering and Physiology”
DESCRIPTION:
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-walter-lee-murfee-iii-ph-d-rediscovering-angiogenesis-at-the-intersection-of-tissue-engineering-and-physiology/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
CATEGORIES:Seminar Series
ORGANIZER;CN="Sherri Childs":MAILTO:sherrich@med.unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20230913T103000
DTEND;TZID=America/New_York:20230913T113000
DTSTAMP:20260415T204121
CREATED:20230816T185353Z
LAST-MODIFIED:20230816T185530Z
UID:10000214-1694601000-1694604600@www.med.unc.edu
SUMMARY:MHI Seminar Series:  Lilei Zhang\, Ph.D.\, M.D.\, “Circadian Regulation in Cardiac Remodeling”
DESCRIPTION:
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-lilei-zhang-ph-d-m-d-circadian-regulation-in-cardiac-remodeling/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Sherri Childs":MAILTO:sherrich@med.unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20200214T143000
DTEND;TZID=America/New_York:20200214T154500
DTSTAMP:20260415T204121
CREATED:20200213T174951Z
LAST-MODIFIED:20200213T174951Z
UID:10000193-1581690600-1581695100@www.med.unc.edu
SUMMARY:2019 Yang Family Biomedical Scholars Lectures:  Li Qian\, Ph.D.\, "Programming And Reprogramming:  What Does It Take To Make A Cardiomyocyte?"
DESCRIPTION:
URL:https://www.med.unc.edu/mhi/event/2019-yang-family-biomedical-scholars-lectures-li-qian-ph-d-programming-and-reprogramming-what-does-it-take-to-make-a-cardiomyocyte/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20181010T100000
DTEND;TZID=America/New_York:20181010T110000
DTSTAMP:20260415T204121
CREATED:20180828T151501Z
LAST-MODIFIED:20180907T114716Z
UID:10000162-1539165600-1539169200@www.med.unc.edu
SUMMARY:MHI Seminar Series: Dr. Brian Kim
DESCRIPTION:Speaker: Dr. Brian Kim\, Stanford University
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-dr-brian-kim/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180522T140000
DTEND;TZID=America/New_York:20180522T150000
DTSTAMP:20260415T204121
CREATED:20180509T173712Z
LAST-MODIFIED:20180509T173927Z
UID:10000167-1526997600-1527001200@www.med.unc.edu
SUMMARY:MHI Seminar Series: David Zawieja\, PhD\, "Lymphatics: the link between the parenchyma\, cardiovascular and immune systems"
DESCRIPTION:Speaker: David Zawieja\, PhD\, Regents Professor and Department Head of Medical Physiology\, Texas A&M University College of Medicine\nTopic: Lymphatics: the link between the parenchyma\, cardiovascular and immune systems
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-david-zawieja-phd/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Chris Mack":MAILTO:cpmack@ad.unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180424T110000
DTEND;TZID=America/New_York:20180424T120000
DTSTAMP:20260415T204121
CREATED:20180314T190617Z
LAST-MODIFIED:20180509T173455Z
UID:10000168-1524567600-1524571200@www.med.unc.edu
SUMMARY:MHI Seminar Series: Melina Kibbe\, MD\, "When Mice are Men: Sex Bias in Surgical Research"
DESCRIPTION:Speaker: Melina Kibbe\, MD\, Colin G. Thomas Jr. Distinguished Professor and Chair\, Department of Surgery\, UNC \nSeminar Title: “When Mice are Men: Sex Bias in Surgical Research” \nObjectives: \n\nTo explain the sex differences that exist with diseases processes.\nTo explain the sex disparity that exists in the development and evaluation of drugs\, devices\, and medical therapies.\nTo discuss the sex disparity that exists in biomedical and clinical research in surgery and other disciplines.\nTo present solutions that can improve sex inclusion in biomedical and clinical research\n\n 
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-speaker-melina-kibbe-md/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180410T140000
DTEND;TZID=America/New_York:20180410T150000
DTSTAMP:20260415T204121
CREATED:20180314T182726Z
LAST-MODIFIED:20180329T194114Z
UID:10000169-1523368800-1523372400@www.med.unc.edu
SUMMARY:MHI Seminar Series: Rong Tian\, MD\, PhD\, "Metabolic Modulation of Cardiac Remodeling"
DESCRIPTION:Speaker: Rong Tian\, MD\, PhD\, Professor of Anesthesiology and Pain Medicine\, Director of the Mitochondria and Metabolism Center\, University of Washington \nSeminar Title: “Metabolic Modulation of Cardiac Remodeling” \nMy research focuses on the molecular mechanisms regulating cell metabolism and energetics. A long-term goal of my laboratory is to understand the role of mitochondria and metabolism in the pathogenesis of human diseases\, in particular cardiovascular diseases. We have utilized molecular and genetic approaches to identify and perturb specific regulators in the key pathways of cardiac energy metabolism in mice and subsequently interrogated the physiological and biochemical responses in vivo during the development of heart failure using multi-nuclear NMR spectroscopy. Our work in the past two decades focused on the oxidative metabolism and mitochondrial ATP synthesis in heart failure using mouse models of altered glucose and fatty acid metabolism in the heart. Our recent work investigates the signaling role of cell metabolism through energy dependent and independent mechanisms. We also seek to decipher the mechanistic link between impaired mitochondrial function the cardiac stress responses. Results of these studies identified an important role of cellular redox state in diseases caused by mitochondrial dysfunction including cardiovascular and neurological pathologies. In collaboration with our clinical colleagues we are translating some of the research findings to clinical applications.
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-rong-tian-md-phd/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180403T140000
DTEND;TZID=America/New_York:20180403T150000
DTSTAMP:20260415T204121
CREATED:20180314T182157Z
LAST-MODIFIED:20180314T184512Z
UID:10000170-1522764000-1522767600@www.med.unc.edu
SUMMARY:MHI Seminar Series: Xander Wehrens\, MD\, PhD\, "Remodeling of calcium release unit proteins in Heart Failure"
DESCRIPTION:Speaker: Xander Wehrens\, MD\, PhD\, Professor\, Director of Cardiovascular Research Institute\, Baylor University\nTopic: “Remodeling of calcium release unit proteins in Heart Failure”
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-xander-wehrens-md-phd/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Jimena Giudice":MAILTO:jimenagiudice@med.unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180327T140000
DTEND;TZID=America/New_York:20180327T150000
DTSTAMP:20260415T204121
CREATED:20180314T181713Z
LAST-MODIFIED:20180314T184414Z
UID:10000201-1522159200-1522162800@www.med.unc.edu
SUMMARY:MHI Seminar Series: Kenneth Walsh\, PhD\, "Clonal Hematopoiesis and Cardiovascular Disease: New Mechanisms\, New Therapeutic Opportunities"
DESCRIPTION:Speaker: Lockhart B. McGuire Professor\, Director of Hematovascular Biology Center\, University of Virginia\nTopic: “Clonal Hematopoiesis and Cardiovascular Disease: New Mechanisms\, New Therapeutic Opportunities”
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-kenneth-walsh-phd/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Rosalind Coleman":MAILTO:rcoleman@unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180320T140000
DTEND;TZID=America/New_York:20180320T150000
DTSTAMP:20260415T204121
CREATED:20180314T175620Z
LAST-MODIFIED:20180316T154213Z
UID:10000160-1521554400-1521558000@www.med.unc.edu
SUMMARY:MHI Seminar Series: Joan Taylor\, PhD\, "GRAFs mind the GAP between muscle fate and function"
DESCRIPTION:Speaker: Joan Taylor\, PhD\, Professor and Vice Chair for Research in Pathology and Lab Medicine\, UNC School of Medicine\nTopic: “GRAFs mind the GAP between muscle fate and function” \nSeminar Synopsis: The overall goal of our research is to characterize the intracellular signaling pathways that govern normal and aberrant growth responses in the cardiovascular and musculoskeletal system.  For this seminar\, I will focus on the role of GRAF family member RhoGAPs in muscle fate and function.  We originally identified GRAF1 (GTPase-regulator for RhoA associated with FAK) in an un-biased screen for Focal Adhesion Kinase binding partners and over the past several years we have shown that GRAF1 (Arhgap26) and it’s family members GRAF2 (Arhgap10) and -3 (Arhgap42) are critical for limiting RhoA activity in muscle (cardiac\, skeletal and smooth) wherein they play unique roles in co-regulating actin and membrane dynamics. In this seminar\, I will highlight our latest studies on GRAF3 which indicate a critical role for this protein in the development and pathogenesis of human hypertension. Moreover\, I will present new evidence to suggest that GRAF1 and GRAF2 may be equally as important for maintaining cardiac and skeletal muscle homeostasis respectively by novel mechanisms that involve mitochondrial quality control. Collectively\, our findings support the possibility that targeting GRAFs might provide promising therapeutic strategies to limit hypertension and striated muscle degeneration.
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-joan-taylor-phd-grafs-mind-the-gap-between-muscle-fate-and-function/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180306T140000
DTEND;TZID=America/New_York:20180306T150000
DTSTAMP:20260415T204121
CREATED:20180221T135407Z
LAST-MODIFIED:20180221T135407Z
UID:10000159-1520344800-1520348400@www.med.unc.edu
SUMMARY:MHI Seminar Series: James F. Martin\, MD\, PhD\, “Hippo Signaling in Heart Regeneration”
DESCRIPTION:Speaker: James F. Martin\, MD\, PhD\, Vivian L. Smith Professor in Regenerative Medicine\, Baylor College of Medicine; Director\, Cardiomyocyte Renewal Lab\, Texas Heart Institute\nTopic: “Hippo Signaling in Heart Regeneration” \nSeminar Synopsis: Dr. Martin is an internationally recognized developmental and regenerative biologist who has made fundamental contributions to our understanding of development\, disease\, and regeneration. He has authored more than 135 peer-reviewed papers in top journals such as Nature\, Science\, Cell\, Developmental Cell\, Plos Genetics\, Development\, and PNAS. His recent groundbreaking work on the Hippo pathway in heart size regulation is a landmark study that led to the insight that the Hippo pathway is an inhibitor of adult heart muscle regeneration. Dr. Martin’s insights revealed new avenues for treatment of human heart failure. Dr. Martin has made fundamental insights into the role of the transcription factor Pitx2 in atrial fibrillation\, the most common sustained arrhythmia in the human population. He made use of the mouse model to investigate Pitx2 in atrial homeostasis but also in left right asymmetric morphogenesis that is essential for human development. Dr. Martin’s studies investigating Pitx2 function in craniofacial development provided insight into the molecular basis of Rieger syndrome. He uncovered a pivotal function for Bmp signaling in endothelial-mesenchymal transition and cardiac valve development. Dr. Martin’s studies uncovered a novel role for canonical Wnt signaling in cardiac progenitor cell diversification. He found the first microRNA implicated in orofacial clefting. Dr. Martin’s studies are highly cited and also reported on by the lay media.
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-james-f-martin-md-phd-hippo-signaling-in-heart-regeneration/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Dr. Frank Conlon":MAILTO:Frank_Conlon@med.unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180220T140000
DTEND;TZID=America/New_York:20180220T150000
DTSTAMP:20260415T204121
CREATED:20180215T195454Z
LAST-MODIFIED:20180221T135036Z
UID:10000157-1519135200-1519138800@www.med.unc.edu
SUMMARY:MHI Seminar Series: Deepak Voora\, MD\, “Genotype-informed Statin Therapy”
DESCRIPTION:Speaker: Dr. Deepak Voora\, MD\, Associate Professor of Medicine\, Department of Cardiology\, Center for Applied Genomics and Precision Medicine at Duke University\nTopic: “Genotype-informed Statin Therapy”\nSeminar Synopsis: Statins are among the most commonly prescribed medications to lower cholesterol and to prevent cardiovascular disease.  Although well tolerated by most patients\, a significant proportion of patients develop musculoskeletal symptoms associated with statin therapy that can lead to premature statin discontinuation\, elevated cholesterol\, and increased risk for cardiovascular events.  Our group was among the first to discover a reduced function genetic variant in the SLCO1B1 gene that predisposes to higher statin concentrations and statin-associated musculoskeletal symptoms (SAMS).  We have extended this finding to higher cholesterol levels in patients with cardiovascular disease treated with statins and tested for effects on cardiovascular events.   The statin-specific nature of SLCO1B1 associations with SAMS that we and others have identified laid the foundation to translate our findings into the clinic.  We have developed a genotype-informed statin therapy (GIST) intervention based on communicating SLCO1B1 genotype based risk for SAMS and tailored prescriptions to reduce the risk of SAMS.  In two prospective studies\, including a randomized clinical trial\, GIST improves perceptions of statin therapy\, increased statin re-initiation\, and lowered cholesterol levels in patients with statin-intolerance.
URL:https://www.med.unc.edu/mhi/event/mhi-seminar-series-presents-dr-deepak-voora-md-genotype-informed-statin-therapy/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
ORGANIZER;CN="Dr. Craig Lee":MAILTO:craig_lee@unc.edu
GEO:35.9036242;-79.0508779
X-APPLE-STRUCTURED-LOCATION;VALUE=URI;X-ADDRESS=1131 Bioinformatics Building 130 Mason Farm Rd. Chapel Hill NC 27514 United States;X-APPLE-RADIUS=500;X-TITLE=130 Mason Farm Rd.:geo:-79.0508779,35.9036242
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20180213T140000
DTEND;TZID=America/New_York:20180213T150000
DTSTAMP:20260415T204121
CREATED:20180209T185833Z
LAST-MODIFIED:20180209T190119Z
UID:10000155-1518530400-1518534000@www.med.unc.edu
SUMMARY:Christopher L. Holley\, MD\, PhD: “Non-coding RNA\, RNA modifications\, and Oxidative Stress in the Heart”
DESCRIPTION:
URL:https://www.med.unc.edu/mhi/event/christopher-l-holley-md-phd-non-coding-rna-rna-modifications-and-oxidative-stress-in-the-heart/
LOCATION:1131 Bioinformatics Building\, 130 Mason Farm Rd.\, Chapel Hill\, NC\, 27514\, United States
GEO:35.9036242;-79.0508779
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END:VEVENT
END:VCALENDAR