{"id":536,"date":"2018-08-13T10:26:49","date_gmt":"2018-08-13T14:26:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/mhi\/?p=536"},"modified":"2018-08-13T10:31:29","modified_gmt":"2018-08-13T14:31:29","slug":"new-nih-funding-for-silvio-antoniak-phd","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/mhi\/new-nih-funding-for-silvio-antoniak-phd\/","title":{"rendered":"New NIH funding for Silvio Antoniak, PhD"},"content":{"rendered":"<p>Silvio Antoniak, PhD, Assistant Professor in the Department of Pathology and Laboratory Medicine and Member of the McAllister Heart Institute, <a href=\"http:\/\/news.unchealthcare.org\/som-vital-signs\/2018\/aug-9\/antoniak-awarded-1-9-million-grant-from-nih-nhlbi\">has been awarded a $1.9-million, five-year grant from the NIH-NHLBI<\/a> to investigate the potential therapeutic approach in inhibiting the coagulation factor Xa or PAR2 in viral myocarditis and H1N1 influenza A virus infection.<\/p>\n<p>The project investigates the contribution of the blood coagulation factor Xa and its receptor, protease-activated receptor 2 (PAR2) to the pathology of virus infections by inhibiting innate antiviral immune responses. Dr. Antoniak showed in collaboration with Dr. U. Rauch (Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin, Germany) and Dr. N. Mackman (UNC Chapel Hill) that PAR2 reduced innate immune responses to Coxsackievirus B3 infection causing a more pronounced viral myocarditis. Furthermore, Dr. Antoniak found that PAR2 and its activator FXa contribute to the pathology of H1N1 influenza A virus infection. The Antoniak lab will use two well-described infection models with Coxsackievirus B3 myocarditis and H1N1 influenza A virus pneumonia to investigate mechanism by which factor Xa and PAR2 enhances virus infections. More importantly, inhibition of the factor Xa-PAR2 pathway might improve antiviral responses.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Silvio Antoniak, PhD, Assistant Professor in the Department of Pathology and Laboratory Medicine and Member of the McAllister Heart Institute, has been awarded a $1.9-million, five-year grant from the NIH-NHLBI to investigate the potential therapeutic approach in inhibiting the coagulation factor Xa or PAR2 in viral myocarditis and H1N1 influenza A virus infection. The project &hellip; <a href=\"https:\/\/www.med.unc.edu\/mhi\/new-nih-funding-for-silvio-antoniak-phd\/\" aria-label=\"Read more about New NIH funding for Silvio Antoniak, PhD\">Read more<\/a><\/p>\n","protected":false},"author":45695,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"class_list":["post-536","post","type-post","status-publish","format-standard","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New NIH funding for Silvio Antoniak, PhD | UNC McAllister Heart Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/mhi\/new-nih-funding-for-silvio-antoniak-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New NIH funding for Silvio Antoniak, PhD | UNC McAllister Heart Institute\" \/>\n<meta property=\"og:description\" content=\"Silvio Antoniak, PhD, Assistant Professor in the Department of Pathology and Laboratory Medicine and Member of the McAllister Heart Institute, has been awarded a $1.9-million, five-year grant from the NIH-NHLBI to investigate the potential therapeutic approach in inhibiting the coagulation factor Xa or PAR2 in viral myocarditis and H1N1 influenza A virus infection. 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