Misty Good, MD, MS
Division Chief, Neonatal-Perinatal Medicine
Associate Professor
UNC Children’s Hospital
101 Manning Drive, 4th Floor, Office 4102
Lab: Mary Ellen Jones 5th Floor
Research
Molecular mechanisms and mucosal immune response of neonatal intestinal diseases
The Good Laboratory is focused on the cellular and molecular mechanisms involved in the pathogenesis of a devastating intestinal disease affecting infants called necrotizing enterocolitis (NEC). The long-term goal of the Good Lab is to understand the signaling pathways regulating the uncontrolled immune response in NEC and how these responses can be prevented through dietary modifications or targeted intestinal epithelial therapies. Her basic science and translational research utilize a bench-to-bedside approach with multiple cutting-edge techniques. In her pre-clinical studies, their team utilizes a humanized neonatal mouse model of NEC to understand the signaling pathways and immune cell responses involved in NEC development. Specifically, the laboratory interrogates ways to modulate the immune response, epithelial cell and stem cell regeneration, as well as early microbial colonization during intestinal inflammation and NEC. In the clinical component of her research program, Dr. Good leads a large multi-center NEC biobank for the dedicated pursuit of biomarkers of disease and to gain greater pathophysiologic insights during NEC in humans. Dr. Good also developed a premature infant intestine-on-a-chip model to study NEC and provide a personalized medicine approach to test new therapeutics. Her laboratory is currently funded with multiple NIH R01 grants and several graduate student projects are available.
Publications: Link to My bibliography https://www.ncbi.nlm.nih.gov/myncbi/misty.good.1/bibliography/public/
Affiliations:
UNC School of Medicine, Department of Pediatrics, Division of Neonatal-Perinatal Medicine https://www.med.unc.edu/pediatrics/npm/team/
Department of Microbiology & Immunology https://www.med.unc.edu/microimm
UNC Children’s Research Institute https://www.med.unc.edu/childrensresearch/
Center for Gastrointestinal Biology and Disease https://www.med.unc.edu/cgibd
