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Shannon M. Wallet

Shannon M. Wallet, PhD
Interim Chair and Associate Professor
Division of Oral and Craniofacial Health Sciences
Associate Dean for Discover and Innovation, Adams School of Dentistry
Koury Oral Health Sciences Building
CB#7455
919-537-3359

Research

My research interests are focused on mechanisms associated with altered innate immune functions, which lead to dysregulated adaptive immunity. Currently my research program has three major arms integrated through with a central philosophy. Specifically, our laboratory focuses on the contribution of epithelial cell biology and signaling to innate and adaptive immune homeostasis and dysfunction. We study the contribution of what I term ‘epithelial cell innate immune (dys)function’ to three major disease conditions: pancreatic cancer, type 1 diabetes (autoimmunity), and periodontal disease (autoinflammation). While appearing to be a diverse research program, we have found that many of the mechanisms and systems in play are surprisingly (or maybe not so surprisingly) similar allowing for rapid translation of our findings. Importantly, previous investigations into the role of epithelial cells in immunobiology have been hindered by a lack of robust primary cell culture techniques, which our laboratory has been able to overcome using both animal and human tissues. Thus, using our novel and unique tools we are able to evaluate our findings in the human conditions, again making translation of our findings that much more feasible.

 

In addition, our laboratory has been a training home for pre-doctoral fellows in pursuit of their PhD, and I have served on over 45 graduate student committees. We also have a long history of providing resources and mentorship to junior faculty and dual trained individuals, including DMD, PhD and MD, PhD. Using tools, skills and resources gained from my past capacity as the Associate Dean for Faculty Affairs at University of Florida and my current position as Associate Dean of Research in the Adams School of Dentistry our group strives to meet the needs of all individuals wishing to part-take in research intensive experiences.

 

Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis. Rocha FRG, Delitto AE, de Souza JAC, González-Maldonado LA, Wallet SM, Rossa Junior C. Sci Rep. 2020 May 8;10(1):7823. doi: 10.1038/s41598-020-64685-y. PMID: 32385413

NLRC4 inflammasome has a protective role on inflammatory bone resorption in a murine model of periodontal disease. Rocha FRG, Delitto AE, de Souza JAC, Maldonado LAG, Wallet SM, Rossa C Jr. Immunobiology. 2020 Jan;225(1):151855. doi: 10.1016/j.imbio.2019.10.004. Epub 2019 Nov 30. PMID: 31848028.

The proteome of extracellular vesicles released by clastic cells differs based on their substrate. Rody WJ Jr, Chamberlain CA, Emory-Carter AK, McHugh KP, Wallet SM, Spicer V, Krokhin O, Holliday LS. PLoS One. 2019 Jul 10;14(7):e0219602. doi: 10.1371/journal.pone.0219602. eCollection 2019. PMID: 31291376

Clastic cells in orthodontic treatment: Translational challenges and recent advances. Rody WJ Jr, Truzman EL, Foster DT, Smith LN, Rocha FG, Sorenson HL, Wallet SM, Holliday LS. Orthod Craniofac Res. 2019 May;22 Suppl 1:180-185. doi: 10.1111/ocr.12285. PMID: 31074132

Oral epithelial membrane-associated mucins and transcriptional changes with Sjögren’s syndrome. Culp DJ, Stewart C, Wallet SM. Oral Dis. 2019 Jul;25(5):1325-1334. doi: 10.1111/odi.13098. Epub 2019 Apr 12. PMID: 30920100

Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine. Gerber MH, Underwood PW, Judge SM, Delitto D, Delitto AE, Nosacka RL, DiVita BB, Thomas RM, Permuth JB, Hughes SJ, Wallet SM, Judge AR, Trevino JG. Int J Mol Sci. 2018 Dec 1;19(12):3836. doi: 10.3390/ijms19123836. PMID: 30513792 Free PMC article.

Linkage of Infection to Adverse Systemic Complications: Periodontal Disease, Toll-Like Receptors, and Other Pattern Recognition Systems. Wallet SM, Puri V, Gibson FC. Vaccines (Basel). 2018 Apr 5;6(2):21. doi: 10.3390/vaccines6020021. PMID: 29621153 Free PMC article. Review.

Soluble CD14, CD163, and CD27 biomarkers distinguish ART-suppressed youth living with HIV from healthy controls. Williams JC, Zhang X, Karki M, Chi YY, Wallet SM, Rudy BJ, Nichols SL, Goodenow MM, Sleasman JW. J Leukoc Biol. 2018 Apr;103(4):671-680. doi: 10.1002/JLB.3A0717-294RR. Epub 2018 Jan 29. PMID: 29377283.

MyD88-mediated innate sensing by oral epithelial cells controls periodontal inflammation. Delitto AE, Rocha F, Decker AM, Amador B, Sorenson HL, Wallet SM. Arch Oral Biol. 2018 Mar;87:125-130. doi: 10.1016/j.archoralbio.2017.12.016. Epub 2017 Dec 16. PMID: 29289808

The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue. Grau KR, Roth AN, Zhu S, Hernandez A, Colliou N, DiVita BB, Philip DT, Riffe C, Giasson B, Wallet SM, Mohamadzadeh M, Karst SM. Nat Microbiol. 2017 Dec;2(12):1586-1591. doi: 10.1038/s41564-017-0057-7. Epub 2017 Nov 6. PMID: 29109476.

Complete list of publications can be found at:

http://www.ncbi.nlm.nih.gov/sites/myncbi/shannon.wallet.1/bibliography/41322655/public/?sort=date&direction= ascending