Department of Pediatrics
5212A Mary Ellen Jones
Vogt Lab Website
acute flaccid myelitis and enterovirus pathogenesis and human immune response
We want to understand why common pediatric respiratory virus infections cause severe disease in some people. Currently we focus on enterovirus D68, which typically causes colds but rarely causes acute flaccid myelitis, a polio-like paralyzing illness in children. We study both the pathogen and the host immune response, as both can contribute to pathogenesis. Projects focus on use of reverse genetic systems to create reporter viruses to infect both human respiratory epithelial cultures and small animal models such as mice. Human monoclonal antibody effects on pathogenesis are also of particular interest.
Vogt MR*, Fu J*, Kose N, Williamson LE, Bombardi R, Setliff I, Georgiev I, Klose T, Rossmann MG, Bochkov YA, Gern JE, Kuhn RJ, Crowe JE Jr. (2020) Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. Science Immunology. 5(49): eaba4902. [cover image, *equal contributors]
Passiak BS*, Vogt MR*#, Wolf M, Sarma A, Vu N. (2020) A Severe Case of Enterovirus A71 Acute Flaccid Myelitis with Encephalitis. Journal of the Pediatric Infectious Diseases Society. piaa067. [*equal contributors, #corresponding author]
Vogt MR, Crowe JE Jr. (2018) Current Understanding of Humoral Immunity to Enterovirus D68. Journal of the Pediatric Infectious Diseases Society. 7(suppl_2):S49-S53.
Vogt MR, Dowd KA, Engle M, Tesh RB, Johnson S, Pierson TC, Diamond MS (2011) Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fc gamma receptor and complement-dependent effector mechanisms. Journal of Virology. 85:11567-80.
Lazear HM, Pinto AK, Vogt MR, Gale M Jr, Diamond MS (2011) Beta interferon controls West Nile virus infection and pathogenesis in mice. Journal of Virology. 85:7186-7194.
Kaufmann B, Vogt MR, Goudsmit J, Holdaway HA, Aksyuk AA, Chipman PR, Kuhn RJ, Diamond MS, Rossmann MG (2010) Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354. Proceedings of the National Academy of Sciences USA. 107:18950-5.
Dunn MD, Rossi SL, Carter DM, Vogt MR, Mehlhop E, Diamond MS, and Ross TM (2010) Enhancement of anti-DIII antibodies by the C3d derivative P28 results in lower viral titers and augments protection in mice. Virology Journal. 7:95.
*Zhang S, *Vogt MR, Oliphant T, Engle M, Bovshik EI, Diamond MS, Beasley DW. Development of resistance to passive therapy with a potently neutralizing humanized monoclonal antibody against West Nile virus (2009) Journal of Infectious Diseases. 200(2):202-5. [*equal contributors].
Vogt MR, Moesker B, Goudsmit J, Jongeneelen M, Austin SK, Oliphant T, Nelson S, Pierson TC, Wilschut J, Throsby M, Diamond MS (2009) Human monoclonal antibodies against West Nile virus induced by natural infection neutralize at a post attachment step. Journal of Virology. 83:6494-507.