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Victor Garcia’s lab addresses the longstanding problem of HIV persistence in a new PLOS Pathogens paper that takes advantage of their bone marrow/liver/thymus (BLT) humanized mouse system. They combine antiretroviral therapy with an immunotoxin designed to target the conserved CD4 binding site of HIV-1 gp120, and they show a dramatic reduction in persistent virus throughout the body. See the article at the link below.

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