Recognizing the limitations associated with current chimeric human-murine liver mouse models for studying hepatitis B virus infection and immunity, Lishan Su’s group has developed a humanized mouse with both human immune system and liver cells. See their new PLOS Pathogens article at the link below.
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1004032