{"id":97,"date":"2014-07-15T17:05:00","date_gmt":"2014-07-15T17:05:00","guid":{"rendered":"https:\/\/wordpress-dev.med.unc.edu\/mmrrc\/services\/unc-rodent-services\/"},"modified":"2023-12-19T12:16:20","modified_gmt":"2023-12-19T17:16:20","slug":"unc-rodent-services","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/mmrrc\/services\/unc-rodent-services\/","title":{"rendered":"UNC Rodent Services"},"content":{"rendered":"<p><!-- portlet_header --><\/p>\n<p><!-- portlet_above --><\/p>\n<p><!-- description --><\/p>\n<h3 style=\"text-align: center;\">UNC Chapel Hill supports a diverse array of phenotyping and genetic services for the mouse research community<\/h3>\n<table border=\"0\">\n<tbody>\n<tr>\n<td valign=\"top\" width=\"50%\">\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"http:\/\/csbio.unc.edu\/CCstatus\/index.py\" target=\"_blank\" rel=\"noopener\">Collaborative Cross Mouse Resource<\/a><\/h4>\n<ul>\n<li>CC Mice and Genotypes<\/li>\n<li>Computational Genomics Tools<\/li>\n<li>High Density Genotyping<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"http:\/\/www.med.unc.edu\/amc\" target=\"_blank\" rel=\"noopener\">Animal Model Generation<\/a><\/h4>\n<ul>\n<li>Transgenic mouse models<\/li>\n<li>Knock-out mice\/ ES Cell Targeting<\/li>\n<li>CRISPR\/Cas9 mediated mouse engineering<\/li>\n<li>Transgenic and Knock-out rats<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"http:\/\/www.med.unc.edu\/ngrrc\" target=\"_self\" rel=\"noopener\">Gnotobiotic Model Generation<\/a><\/h4>\n<ul>\n<li>Germ-free Mice and Rats<\/li>\n<li>Selectively Colonized Strains<\/li>\n<li>Specialized Diets<\/li>\n<li>Gavage Feeding<\/li>\n<li>Rectal Instillation<\/li>\n<li>Bone Marrow\/HSC Transplant<\/li>\n<li>IP injections of Immune Cells<\/li>\n<li>Intestinal Surgery<\/li>\n<li>Tissue collection<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a title=\"\" href=\"https:\/\/www.med.unc.edu\/clinicalchemistry\/\" target=\"_self\" rel=\"noopener\">Animal Clinical Chemistry &amp; Gene Expression<\/a><\/h4>\n<ul>\n<li>Blood Chemistry<\/li>\n<li>Urinalysis<\/li>\n<li>Hematology<\/li>\n<li>Real-Time RTPCR<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"https:\/\/unclineberger.org\/pathologyservices\/\" target=\"_blank\" rel=\"noopener\">Animal Histopathology<\/a> and <a class=\"external-link\" title=\"\" href=\"https:\/\/histologyresearchcorefacility.web.unc.edu\/\" target=\"_blank\" rel=\"noopener\">Histology Research<\/a><\/h4>\n<ul>\n<li>Frozen and Paraffin Histology (Processing, embedding, sectioning, H&amp;E and other staining)<\/li>\n<li>Vibratome Sectioning for EM<\/li>\n<li>IHC and ISH<\/li>\n<li>Pathology Consulation<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"http:\/\/unclineberger.org\/animal-studies\" target=\"_blank\" rel=\"noopener\">General Animal Studies<\/a><\/h4>\n<ul>\n<li>Aseptic Surgery<\/li>\n<li>Orthotopic Injections<\/li>\n<li>Tumor Passage<\/li>\n<li>Tissue\/Blood Studies<\/li>\n<li>Intra-Cardiac (and other) Injections<\/li>\n<li>IVIS imaging<\/li>\n<\/ul>\n<\/div>\n<\/td>\n<td width=\"50%\">\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"https:\/\/www.med.unc.edu\/mhi\/surgicalmodels\/\" target=\"_blank\" rel=\"noopener\">Rodent Cardiovascular and Transplant Advanced Surgical Models<\/a><\/h4>\n<ul>\n<li>Heterotopic Heart, Renal, Liver, Pancreatic, Small Bowel, Esophageal\/Tracheal, Unterine Horn, Transplantation<\/li>\n<li>Aortic (Vascular) Graft Transplantation<\/li>\n<li>Free Composite Tissue Vascularized Transplantation (both standard and custom-designed models)<\/li>\n<li>Large-Vessel Electrolytic Injury, Collagen Induction, Mechanical Injury, Microvessel Laser Injury (with intravital fluorescence imaging and quantitative data analysis)<\/li>\n<li>Microvessel, Carotid Artery Ferric Chloride Injury<\/li>\n<li>Inferior Vena Cava Ligation (either total or partial ligation)<\/li>\n<li>Saphenous Vein Laser Puncture or Stab Puncture Haemostasis Assay<\/li>\n<li>Tail\/Microvessel Bleed Assay (with intravital fluorescence imaging)<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"https:\/\/cidd.unc.edu\/Research\/mouseBehavioralPhenotyping.aspx\" target=\"_blank\" rel=\"noopener\">Mouse Behavioral Phenotyping<\/a><\/h4>\n<ul>\n<li>General Behavior Measures<\/li>\n<li>Home Cage Behavior<\/li>\n<li>Neurobehavioral Reflexes and Motor Function<\/li>\n<li>Sensory Tasks<\/li>\n<li>Anxiety, Depression-Related and Repetitive Behaviors<\/li>\n<li>3-Chamber Social Approach<\/li>\n<li>Learning and Memory<\/li>\n<li>Sensorimotor Gating<\/li>\n<li>Neonatal Assessment<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"https:\/\/norc.unc.edu\/research-core\/metabolic-phenotyping\/\" target=\"_blank\" rel=\"noopener\">Animal Metabolism Phenotyping<\/a><\/h4>\n<ul>\n<li>Calorimetry<\/li>\n<li>MRI<\/li>\n<li>Voluntary Running Wheel and Treadmill<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"https:\/\/www.med.unc.edu\/bric\/small-animal-imaging\/\" target=\"_blank\" rel=\"noopener\">Animal Imaging<\/a><\/h4>\n<ul>\n<li>MRI<\/li>\n<li>PET Imaging<\/li>\n<li>SPECT Imaging<\/li>\n<li>MicroCT Imaging<\/li>\n<li>Ultrasound Imaging<\/li>\n<li>Optical Imaging<\/li>\n<\/ul>\n<\/div>\n<div class=\"alert alert-blue\">\n<h4 style=\"text-align: center; padding-bottom: 1em;\"><a class=\"external-link\" title=\"\" href=\"http:\/\/www.med.unc.edu\/mousephase1\" target=\"_blank\" rel=\"noopener\">Pre-Clinical Mouse Cancer Models<\/a><\/h4>\n<ul>\n<li>Administering treatments (IP, IV, subQ injections; medicated chow; etc)<\/li>\n<li>Serial imaging (Ultrasound, IVIS, PET)<\/li>\n<li>Pharmacology and pharmacokinetics<\/li>\n<li>Molecular target validation<\/li>\n<li>Tissue\/Blood collection<\/li>\n<\/ul>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>UNC Chapel Hill supports a diverse array of phenotyping and genetic services for the mouse research community Collaborative Cross Mouse Resource CC Mice and Genotypes Computational Genomics Tools High Density Genotyping Animal Model Generation Transgenic mouse models Knock-out mice\/ ES Cell Targeting CRISPR\/Cas9 mediated mouse engineering Transgenic and Knock-out rats Gnotobiotic Model Generation Germ-free Mice &hellip; <a href=\"https:\/\/www.med.unc.edu\/mmrrc\/services\/unc-rodent-services\/\" aria-label=\"Read more about UNC Rodent Services\">Read more<\/a><\/p>\n","protected":false},"author":1369,"featured_media":0,"parent":36,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-97","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/pages\/97","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/users\/1369"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/comments?post=97"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/pages\/97\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/pages\/36"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/mmrrc\/wp-json\/wp\/v2\/media?parent=97"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}