The mission of the AIDS Neurological Center is to conduct research and provide clinical support on HIV-associated neurocognitive disorders. The Center investigators conduct both clinical and basic neuroscience research on the neurological and neuropsychological aspects of HIV and AIDS. The Center participates in and supports clinical trials with a neurological focus in the UNC AIDS Clinical Trials Unit locally and the AIDS Clinical Trials Group in the United States and internationally. Through the clinical component, the Center provides clinical consultation and evaluation for HIV and AIDS related neurological and neuropsychological disorders. The Center has an active basic neuroscience research program focused on the pathogenesis of HIV-associated neurocognitive disorders.