Publications 2022

Publications by UNC Neurology faculty and residents in 2022 include the following:

Latorius Admas, MS published an article in The Pilot on October 4, 2022, Brain Health” “The operating system for a happy, healthy, joyful life”

Irena Dujmovic Basuroski, MD, co-authored, “In utero exposure to maternal anti–aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring.” Science Translational Medicine, April 2022.

Irena Dujmovic Basuroski, MD, and other researchers co-authored, “Paraneoplastic Optic Neuropathy in a Patient with Glioblastoma,” Journal of Neuro-Ophthalmology, June 14, 2022.

UNC Neurology residents, Carolyn Tsai, MD, and Abigail O’Reggio, MD, mentored by Anahit Mehrabyan, MD; Dena Williams, DO; and Irena Dujmovic Basuroski, MD, co-authored “Bilateral Acute Hippocampal Ischemia in Two Patients Abusing Cocaine: What is the Outcome?,” Cureus, June 29, 2022.

Irena Dujmovic Basuroski, MD, co-authored:

Dr. Irena Dujmovic Basuroski and her colleagues published “String of Pearls” in Spinal Cord Sarcoidosis in Annals of Neurology. doi: 10.1002/ana.26471.
Dr. Irena Dujmovic Basuroski became a Steering Committee Member of The European Consortium for Cerebrospinal Fluid Biomarker Research in Multiple Sclerosis.

Irena Dujmovic Basuroski, MD and her colleagues published “Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders” in Front Immunol. doi: 10.3389/fimmu.2022.900605.

Andrea C. Bozoki, MD, co-authored “Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders.” Cell Rep Med. PubMed, Apr 19, 2022.

Miriam Sklerov, MD, MS; Nina Browner, MD; David Rubinow, MD; Eran Dayan, PhD; and Flavio Frohlich, PhD, co-authored “Autonomic and depression symptoms in Parkinson’s disease: clinical evidence for overlapping physiology” in Journal of Parkinson’s Disease, February 2022.

Jamie K. Capal, MD, co-authored, “The research landscape of Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders (TAND)—a comprehensive scoping review,” Journal of Neurodevelopmental Disorders, February 2022.

Jamie Capal, MD, authored “Describing Autism Spectrum Disorder in Tuberous Sclerosis: Challenges and Future Opportunities,” a commentary on “The autism spectrum disorder phenotype in children with tuberous sclerosis complex: a systematic review and meta-analysis” by Rebecca Mitchell, et al. Developmental Medicine & Child Neurology. May 28, 2022.

Julia Carlson, MD, is the lead author of “Early Withdrawal of Life Sustaining Therapy in Extracorporeal Cardiopulmonary Resuscitation (ECPR): Results from the Extracorporeal Life Support Organization Registry”, Resuscitation, October 2022.

Diana Cejas, MD, MPH, co-authored, “Health Equity for Children and Youth with Special Health Care Needs: A Vision for the Future,” Pediatrics, June 1, 2022.

Monica Diaz, MD, MS, co-authored, “HIV and COVID-19 in Latin America and the Caribbean,” Current HIV/AIDS Reports, January 2022.

Dr. Diaz also co-authored an abstract, “Cognitive Predictors of Everyday Functioning in the Women’s Interagency HIV Study,” presented as a poster at the Conference of Retroviruses and Opportunistic Infections, Feb 12-16, 2022.

Monica Diaz, MD, MS, was first author of “Prevalence of Epilepsy, Human Cysticercosis, and Porcine Cysticercosis in Western Kenya.” The American Journal of Tropical Medicine and Hygiene, online March 14, 2022.

Monica Maria Diaz, MD, MS, co-authored:

“HIV and Substance Use in Latin America: A Scoping Review,” International Journal of Environmental Research and Public Health, June 12, 2022.

“A Functional Assessment Tool to Distinguish Controls From Alzheimer’s Disease in Lima, Peru,” American Journal of Alzheimer’s Disease and Other Dementias, June 3, 2022.

“Toward Composite Pain Biomarkers of Neuropathic Pain-Focus on Peripheral Neuropathic Pain,” Frontiers in Pain Research, May 11, 2022.

“Validation of Picture Free and Cued Selective Reminding Test for Illiteracy in Lima, Peru,” American Journal of Alzheimer’s Disease and Other Dementias, April 24, 2022.

Monica Diaz, MD, MS, co-authored:

Biomarkers for dementia in Latin American countries: Gaps and opportunities. Alzheimers Dement. PubMed, September 13, 2022.
Combining visual rating scales to identify prodromal Alzheimer’s disease and Alzheimer’s disease dementia in a population from a low and middle-income country. Frontiers in Neurology. Sep 1, 2022.

Monica Diaz, MD, MS, co-authored:

Njie-Carr, Veronica P. S. PhD, RN, ACNS-BC*; Zhu, Shijun PhD, DrE; Stafford, Kristen A. PhD, MPH; Tong, Weiqun MS; Plankey, Michael PhD; Sharma, Anjali MD, MS; Milam, Joel PhD; Cohen, Mardge MD; Diaz, Monica M. MD, MS; Rubtsova, Anna A. PhD, MSc; Fischl, Margaret A. MD; Konkle-Parker, Deborah PhD, FNP, FAAN; Gustafson, Deborah PhD, MS; Rubin, Leah H. PhD, MPH. Intersectionality of Socioecological Factors Associated With Cognitive Function Among Older Women With HIV in the United States: A Structural Equation Model Analysis Using Data From the Women’s Interagency HIV Study. Journal of the Association of Nurses in AIDS Care: December 12, 2022 – Volume – Issue – 10.1097. https://journals.lww.com/janac/Abstract/9900/Intersectionality_of_Socioecological_Factors.37.aspx

Jane Fan, MD, co-authored “Evaluation of electroencephalography biomarkers for Angelman syndrome during overnight sleep.” Autism Research. March 19, 2022.

Timothy Gershon, MD, PhD, was a member of the UNC Lineberger Comprehensive Cancer Center team that demonstrated that a nanoparticle-formulated drug combination is effective in medulloblastoma, the most common pediatric brain tumor. The team believes this laboratory success could be translated into a less toxic treatment. Science Advances, January 26, 2022; Lineberger News article

James F. Howard, Jr., MD, was co-author of three articles:

“Pathogenic TNF-alpha drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity,” Proceedings of the National Academy of Sciences USA, January 2022.
“Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study,” Proceedings of the National Academy of Sciences USA, February 2022.

James F. Howard, Jr., MD, co-authored:

Role attainment in emerging adulthood: subjective evaluation by male adolescents and adults with Duchenne and Becker muscular dystrophy. Journal of Neuromuscular Diseases, March 5, 2022.

Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys with Duchenne Muscular Dystrophy: A Randomized Clinical Trial. JAMA, April 19, 2022. Co-authored with Manisha Chopra, MBBS, and other researchers.

Classical complement pathway inhibition in a ‘human-on-a-chip’ model of autoimmune demyelinating neuropathies Advanced Therapeutics. Advanced Therapeutics, April 5, 2022. Co-authored with Manisha Chopra, MBBS, and other researchers.

James F. Howard, Jr., MD, co-authored:

“Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis,” NEJM Evidence, April 26, 2022. Co-authored with Manisha Chopra, MBBS, and other researchers.
“Selected clinical and demographic factors and all-cause mortality among individuals with Duchenne muscular dystrophy in the Muscular Dystrophy Surveillance, Tracking, and Research Network,” Neuromuscular Disorders, May 2022.

James F. Howard Jr, MD; Rebecca Traub, MD; Steven Trau, MD; and Jose Sanchez co-authored “Electrodiagnostic Findings in Riboflavin Transporter Deficiency Type 2,” Journal of Clinical Neuromuscular Disease, June 1, 2022.

James F Howard Jr, MD, co-authored:

Classical Complement Pathway Inhibition in a “Human-On-A-Chip” Model of Autoimmune Demyelinating Neuropathies. Adv Ther (Weinh). 2022 Jun;5(6):2200030. doi: 10.1002/adtp.202200030. Epub 2022 Apr 5. PMID: 36211621; PMCID: PMC9540753.
Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis. NEJM Evidence 2022-04-26T13:30:00Z 1(5): EVIDoa2100066, doi: 10.1056/EVIDoa2100066.
Selected clinical and demographic factors and all-cause mortality among individuals with Duchenne muscular dystrophy in the Muscular Dystrophy Surveillance, Tracking, and Research Network Neuromuscular Disorders 2022, May Epub ahead of publication, doi: 0.1016/j.nmd.2022.04.008.
Electrodiagnostic findings in Riboflavin Transporter Deficiency Type 2. Journal of Clinical Neuromuscular Disease June 2022 – Volume 23(4): 205-209 doi: 10.1097/CND.000000000000039, PMID: 35608644.

Dave Hwang, MD, is the senior author for “A pilot randomized clinical trial of a goals-of-care decision aid for surrogates of severe acute brain injury patients,” Neurology, July 2022, and “Psychological attachment orientations and long-term post-traumatic stress symptoms among family members of intensive care unit patients,” Critical Care Explorations, August 2022. He also authored “Patients’ families, physicians, and nurses: trying to see eye-to-eye regarding prognosis in neurocritical care”, Neurocritical Care, August 2022, and co-authored “Top ten tips palliative care clinicians should know about disorders of consciousness: a focus on traumatic and anoxic brain injury”, Journal of Palliative Medicine, October 2022.

Gary Jay, MD, co-authored “Trigeminal neuralgia and persistent idiopathic facial pain (atypical facial pain),” Disease-a-Month, January 2022.

Grace DeHoff, DO, and Winnie Lau, MD co-authored “Medical management of cerebral edema in large hemispheric infarcts,” Frontiers in Neurology, November 2022.

Winnie Lau, MD, is the senior author of “Cerebral venous sinus thrombosis with an acute subdural hematoma treated with endovascular intervention: A case report”, Frontiers in Neurology, October 2022.

Casey Olm-Shipman, MD, MS, was also co-author of the following publication: Karanjia, N., Dugyala, V., Olm-Shipman, C. Lele AV. Quality Improvement in Neurocritical Care: a Review of the Current Landscape and Best Practices. Curr Treat Options Neurol (2022). https://doi.org/10.1007/s11940-022-00734-3

Yasmeen Rauf, MD, wrote a book chapter, “Neurological complications of systemic cancer of the head and neck” that was published in “Neurological complications of systemic cancer and antineoplastic therapy,” 2^nd Edition.

Daniel Roque, MD, published along with diverse groups of researchers. Morowitz JM, Pogson KB, Roque DA, Church FC. Role of SARS-CoV-2 in Modifying Neurodegenerative Processes in Parkinson’s Disease: A Narrative Review. Brain Sci. 2022 Apr 22;12(5):536. doi: 10.3390/brainsci12050536. PMID: 35624923; PMCID: PMC9139310. https://pubmed.ncbi.nlm.nih.gov/35624923/

Clio Rubinos, MD, MSCR; Carolyn Tsai, MD; and Susan E. Wilson, DNP co-authored “SARS-CoV-2 infection and seizures: The Perfect Storm,” Journal of Integrative Neuroscience, June 2022.

Clio Rubinos, MD, MSCR; Fazila Aseem, MD, MPH; Winnie Lau, MD; Casey Olm-Shipman, MD, MS; Matthew F. Sharrock, MD; Rhonda Cadena, MD; and Courtney Blodgett, AG-ACNP along with other researchers co-authored “Dermat-Neur Syndrome in a COVID-19 patient with well-controlled scleromyxedema,” The Rheumatologist, June 2022.

Clio Rubinos, MD, MSCR, co-authored “Predicting Shunt Dependency from the Effect of Cerebrospinal Fluid Drainage on Ventricular Size,” Neurocritical Care Journal, June 15, 2022.

Clio Rubinos, MD, MSCR, is the lead author for 2 publications:

Rubinos C., Blodgett C., Bruzzone MJ., Tsai C., Patel P., Hianik R., Jadav R., Boudesseul J., Liu C., Zhu H., Wilson S., Olm-Shipman C., Meeker R., Hirsch L. Association of serum Pyridoxine levels with benzodiazepine-resistant status epilepticus. Neurocritical Care PMID: 36071331
Rubinos C., Waters B., Hirsch L. Predicting and Treating Post-Traumatic Epilepsy. Curr Treat Options Neurol (2022). https://doi.org/10.1007/s11940-022-00727-2

Clio Rubinos, MD, MSCR, authored a July newsletter article for the Neurocritical Care Society entitled, “Continuous EEG Monitoring in Intensive Care Units in Resource-Limited Settings: A Necessary Skill for Intensivists.” https://currents.neurocriticalcare.org/blogs/currents-editor/2022/06/07/continuous-eeg-monitoring-in-intensive-care-units-

Clio Rubinos, MD, MSCR, co-authored an article for the Neurocritical Care Society newsletter entitled, “Neurointensive Care in Latin America: A Bright Future Ahead.” It is available at: https://currents.neurocriticalcare.org/blogs/currents-editor/2022/08/15/neurointensive-care-in-latin-america-a-bright-futu

Fatemeh Sadeghifar, MD

PGY1 Resident Fatemeh Sadeghifar published: Ongchuan Martin S, Sadeghifar F, Snively BM, Alexander H, Kimball J, Conner K, O’Donovan CA, Munger Clary HM. Positive anxiety or depression screen despite ongoing antidepressant prescription in people with epilepsy: A large cross-sectional analysis. Epilepsy Behav Rep. 2022 Nov 7;20:100572. doi: 10.1016/j.ebr.2022.100572. PMID: 36411879; PMCID: PMC9674492. PubMed >

Matthew Field Sharrock, MD, co-authored “Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.” Journal of Neuroimaging, April 2022. The paper introduces a technique that allows investigators to assess AI model uncertainty levels when using automated imaging measurements in a clinical trial, particularly when different types of injuries intersect and there are questions about which one predominates.

Ian Shih, Esteban A. Oyarzabal, Li-Ming Hsu, Manasmita Das, Tzu-Hao Harry Chao, Sheng Song, Weiting Zhang, Hong Yuan, Sung-Ho Lee and other Triangle Park researchers co-authored, “Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network.” Science Advances, March 2022. UNC Health article >

Ian Shih, PhD, and the CAMRI team, Lindsay Walton, PhD; Matthew Verber

, MS; Sung-Ho Lee, DVM, PhD; Tzu-Hao Harry Chao, PhD; and R. Mark Wightman, PhD, received NeuroImage’s 2022 Paper of the Year Award for their paper, “Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales.” The team won by a large margin topping 1,000 published papers and 3,500 submissions. View paper >

Claudia Testa, MD, PhD, co-authored a book, “Tremors” to be published by Oxford University Press in March 2022. The book includes a chapter with first authorship by PGY2 residen

t, Laura de Lima Xavier, MD.

The book, “Tremors,” co-authored by Claudia Testa, MD, PhD, is now available. The book includes a chapter with first authorship by PGY2 resident, Laura de Lima Xavier, MD. (Publis

hed by Oxford University Press.)

Zarin Tabassum, Jui-Heng Tseng, Camryn Isemann, Xu Tian, Youjun Chen, Todd Cohen and Laura Herring (UNC Department of Pharmacology) co-authored, “Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase” Journal of Biological Chemistry, April 2022

John Younce, MD, published as co-first author in Annals of Neurology. Martin WRW, Younce JR, Campbell MC, Racette BA, Norris SA, Ushe M, Criswell S, Davis AA, Alfradique-Dunham I, Maiti B, Cairns NJ, Perrin RJ, Kotzbauer PT, Perlmutter JS. Neocortical Lewy body pathology parallels Parkinson’s dementia, but not always. Ann Neurol. 2022 Nov 4. doi: 10.1002/ana.26542. Epub ahead of print. PMID: 36331161. https://pubmed.ncbi.nlm.nih.gov/36331161/

Latorius Admas, MS

Irena Dujmovic Basuroski, MD

Andrea C. Bozoki, MD

Nina Browner, MD

Jamie K. Capal, MD

Julia Carlson, MD

Diana Cejas, MD, MPH

Eran Dayan, PhD

Monica Diaz, MD, MS

Jane Fan, MD

Flavio Frohlich, PhD

Timothy Gershon, MD, PhD

James F. Howard, Jr., MD

Dave Hwang, MD

Gary Jay, MD

Winnie Lau, MD

Casey Olm-Shipman, MD, MS

Yasmeen Rauf, MD

Daniel Roque, MD

Clio Rubinos, MD, MSCR

Fatemeh Sadeghifar, MD

David Rubinow, MD

Matthew Field Sharrock, MD

Yen-Yu Ian Shih, PhD

Miriam Sklerov, MD

Claudia Testa, MD, PhD

Jui-Heng Tseng

John Younce, MD