Publications 2023
Publications by UNC Neurology faculty and residents in 2023 include the following:
Li X, Landis T, Karazanashvili N, Diaz MM. Anti-IgLON5 disease exacerbated by asymptomatic SARS-CoV-2 infection. Neuroimmunology Reports. 2023;3:100166. doi: 10.1016/j.nerep.2023.100166. Epub 2023 Feb 5. PMCID: PMC9899159.
Njie-Carr, Veronica P. S. PhD, RN, ACNS-BC*; Zhu, Shijun PhD, DrE; Stafford, Kristen A. PhD, MPH; Tong, Weiqun MS; Plankey, Michael PhD; Sharma, Anjali MD, MS; Milam, Joel PhD; Cohen, Mardge MD; Diaz, Monica M. MD, MS; Rubtsova, Anna A. PhD, MSc; Fischl, Margaret A. MD; Konkle-Parker, Deborah PhD, FNP, FAAN; Gustafson, Deborah PhD, MS; Rubin, Leah H. PhD, MPH. Intersectionality of Socioecological Factors Associated With Cognitive Function Among Older Women With HIV in the United States: A Structural Equation Model Analysis Using Data From the Women’s Interagency HIV Study. Journal of the Association of Nurses in AIDS Care: December 12, 2022 – Volume – Issue – 10.1097. https://journals.lww.com/janac/Abstract/9900/Intersectionality_of_Socioecological_Factors.37.aspx
James Howard, MD, professor of neurology at the UNC School of Medicine, was the principal investigator of the RAISE clinical trial of zilucoplan, one of two drugs under regulatory review to treat myasthenia gravis. Rozanolixizumab, Zilucoplan Phase 3 Generalized Myasthenia Gravis Study Results Published in The Lancet Neurology
Mann J, Zhang Y, McDermott S, Wang Y, Cai B, Conway KM, Paramsothy P, Royer J, Venkatesh S, Howard JF Jr, Ciafaloni E and the MD STARTnet. Racial and ethnic differences in timing of diagnosis and clinical services received in Duchenne Muscular Dystrophy. Neuroepidemiology. 2023 Jan 9. doi: 10.1159/000528962. Epub ahead of print. PMID: 36623491.
Masi G, Pham MD, Karatz T, Oh S, Payne AS, Nowak RJ, Howard JF Jr, Guptil JT, Juel VC, O’Connor KC. Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis. Annals of Clinical and Translational Neurology. 2023 Mar 16. doi: 10.1002/acn3.51761. Epub ahead of print. PMID: 36924454.
Vu T, Ortiz S, Katsuno M, Annane D, Mantegazza R, Beasley KN, Aguzzi R, Howard JF Jr. Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis. Journal of Neurology. 2023 Mar 9. doi: 10.1007/s00415-023-11617-1. Epub ahead of print. PMID: 36890354.
Whitehead N, Erickson SW, Cai B, McDermott S, Peay H, Howard JF Jr, Ouyang L and the Muscular Dystrophy Surveillance, Tracking and Research Network. Sources of variation in estimates of Duchenne and Becker Muscular Dystrophy prevalence in the United States. Orphanet Journal of Rare Diseases. 2023 Mar 22;18(1):65. doi: 10.1186/s13023-023-02662-0. PMID: 36949506; PMCID: PMC10031951.
Howard JF Jr, Bresch S, Genge A, Hewamadduma C, Hinton J, Hussain Y, Juntas-Morales R, Kaminski HJ, Maniaol A, Mantegazza R, Masuda M, Sivakumar K, Śmiłowski M, Utsugsawa K, Vu T, Weiss MD, Zajda M, Boroojerdi B, Brock M, de la Borderie G, Duda PW, Lowcock R, Vanderkelen M, Leite MI and the RAISE investigators (Chopra M, Traub RE). Efficacy and safety of zilucoplan in patients with generalised myasthenia gravis: A randomised, double-blind, placebo-controlled, Phase 3 study (RAISE). Lancet Neurology. 2023 May;22(5):395-406. doi: 10.1016/S1474-4422(23)00080-7. PMID: 37059508.
Guptill JT, Benatar M, Granit V, Habib A, Howard JF Jr, Barnett-Tapia C, Nowak RJ, Lee I, Ruzhansky K, Dimachkie M, Cutter G, Kaminski HJ. Addressing Outcome Measure Variability in MG Clinical Trials. Neurology. 2023 Apr 19:10.1212/WNL.0000000000207278. doi: 10.1212/WNL.0000000000207278. Epub ahead of print. PMID: 37076302.
Meisel A, Annane D, Vu t, Mantegazza R, Katsuno M, Aguzzi R, Frick G, Gault L, Howard JF Jr, and the CHAMPION MG Study Group (Chopra M). Long-term efficacy and safety of ravulizumab in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis: results from the phase 3 CHAMPION MG open-label extension. Journal of Neurology. 2023 Apr 27:1–14. doi: 10.1007/s00415-023-11699-x. Epub ahead of print. PMID: 37103755; PMCID: PMC10134722.
Vu T, Ortiz S, Katsuno M, Annane D, Mantegazza R, Beasley KN, Aguzzi R, Howard JF Jr. Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis. Journal of Neurology. 2023 Jun;270(6):3129-3137. doi: 10.1007/s00415-023-11617-1. Epub 2023 Mar 9. PMID: 36890354; PMCID: PMC10188401.
Vu T, Meisel A, Mantegazza R, Annane D, Katsuno M, Aguzzi R, Enayetallah A, Beasley KN, Rampal N, Howard JF Jr. Summary of Research: Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis. Neurol Ther. 2023 Jun 23. doi: 10.1007/s40120-023-00514-4. Epub ahead of print. PMID: 37351816.
Granit V*, Benatar M*, Kurtoglu M, Miljkovic M, Chahin N, Sahagian G, Feinberg M, Slansky A, Vu T, Singer M, Kalayoglu M, Howard JF Jr**, Mozaffar T** and the MG-001 Study Team (Chopra M). Safety and Efficacy of Autologous RNA CAR-T Therapy in Myasthenia Gravis [*both first authors contributed equally, ** both senior authors contributed equally]. The Lancet Neurology. 2023 22:579-590. doi: 10.1016/S1474-4422(23)00194-1. PMID: 37353278.
Casey Olm-Shipman, MD, MS, and Dave Hwang, MD, co-authored the following publication:
Waseem, H., J. Keegan, K. Farrell, D.Y. Hwang, B. Oliver, C. Olm-Shipman, R. Pepin, and J. Mecchella. Implementation of a standardized shared decision-making bundle to improve communication practices in the neurocritical care unit. Neurology: Clinical Practice. 2023, 13: e200120.
Dave Hwang, MD, co-authored the following publication:
Ammar, A.A., A.A. Elsamadicy, M.A. Ammar, B.C. Reeves, A.B. Koo, G.J. Falcone, D.Y. Hwang, N. Petersen, J.A. Kim, R. Beekman, M. Prust, J. Magid-Bernstein, J.N. Acosta, R. Hebert, K.N. Sheth, C.C. Matouk, and E.J. Gilmore. Emergency external ventricular drain placement in patients with Factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology and Neurosurgery. 2023, 226: 107621.
Dave Hwang, MD, also was a co-author for two new sets of joint guidelines from the U.S. and German Neurocritical Care Societies:
Busl, K.M., H. Fried, S. Muehlschlegel, K.E. Wartenberg, V. Rajajee, S.A. Alexander, C.J. Creutzfeldt, G.V. Fontaine, S.E. Hocker, D.Y. Hwang, K.S. Kim, D. Madzar, D. Mahanes, S. Mainali, J. Meixensberger, O.W. Sakowitz, P.N. Varelas, T. Westermaier, and C. Weimar. Guidelines for neuroprognostication in adults with Guillain-Barré Syndrome. Neurocritical Care. 2023, doi: 10.1007/s12028-023-01707-3.
Rajajee, V., S. Muehlschlegel, K.E. Wartenberg, S.A. Alexander, K.M. Busl, S.H.Y. Chou, C.J. Creutzfeldt, G.V. Fontaine, H. Fried, S.E. Hocker, D.Y. Hwang, K.S. Kim, D. Madzar, D. Mahanes, S. Mainali, J. Meixensberger, F. Montellano, O.W. Sakowitz, C. Weimar, T. Westermaier, and P.N. Varelas. Guidelines for neuroprognostication in comatose adult survivors of cardiac arrest. Neurocritical Care. 2023, doi: 10.1007/s12028-023-01688-3.
Winnie Lau, MD, and Dave Hwang, MD, were both co-authors for the newly released 2023 AAN Neuropalliative Care Curriculum document for program and fellowship directors: https://www.aan.com/tools-resources/academic-core-curricula
Winnie Lau, MD, and Dave Hwang, MD, were both co-authors for the newly released 2023 AAN Neuropalliative Care Curriculum document for program and fellowship directors: https://www.aan.com/tools-resources/academic-core-curricula
Casey Olm-Shipman, MD, MS, was also co-author of the following publication: Karanjia, N., Dugyala, V., Olm-Shipman, C. Lele AV. Quality Improvement in Neurocritical Care: a Review of the Current Landscape and Best Practices. Curr Treat Options Neurol (2022). https://doi.org/10.1007/s11940-022-00734-3
The UNC Tremor Interdisciplinary Clinic debuted at UNCH Neurology Clinics at Meadowmont. Under the direction of Dr. Daniel Roque, this clinic offers multiple visits with subspecialists trained in tremor management, including movement disorders neurology, functional neurosurgery (Dr. Vibhor Krishna), and occupational therapy (Melissa Collins, CHT, MOT), while offering research opportunities for those who qualify and are interested in participating
Daniel Roque, MD, collaborated as co-PI on a conference submission and co-authored a publication “Nonlinear System Identification of Tremors Dynamics: A Data-driven Approximation Using Koopman Operator Theory” to the 2023 11th International IEEE/EMBS Conference on Neural Engineering (NER) with Dr. Nitin Sharma, associate professor of biomedical engineering at NSCU/UNC
Daniel Roque, MD, coauthored a publication “Towards Ultrasound Imaging-based Closed-loop Peripheral Nerve Stimulation for Tremor Suppression” found within Current Opinion in Biomedical Engineering with Dr. Nitin Sharma, associate professor of biomedical engineering at NSCU/UNC
Punia V, Li Y, Lapin B, Chandan P, Newey C, Hantus S, Dhakar M, Rubinos C, Zafar S, Sivaraju A, Katzan I, for Post-Acute Symptomatic Seizure Investigation and Outcomes Network (PASSION) investigators. Impact of Acute Symptomatic Seizures and their management on patient-reported outcomes after stroke. Epilepsy Behav Feb 2023 PMID: 3604847
Alsbrook D, Di Napoli M, Bhatia K, Desai M, Hinduja A, Rubinos C, Mansueto G, Singh P, Domeniconi G, Irkam A, Sabbagh S, Divani A. Pathophysiology of Early Brain Injury and its Association with Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Review of Current Literature. J Clin Med Jan 2023 PMID: 36769660
Shih lab: Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network. Nature Communications, (Editor’s highlight article).
Neuronal dynamics of the default mode network and anterior insular cortex: Intrinsic properties and modulation by salient stimuli. Science Advances, [Press release] [News video].
A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience, (Cover of the issue)
Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon. Frontiers in Immunology
Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen. Journal of Cerebral Blood Flow & Metabolism