{"id":3009,"date":"2017-07-26T18:40:00","date_gmt":"2017-07-26T22:40:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/"},"modified":"2022-12-05T13:31:31","modified_gmt":"2022-12-05T18:31:31","slug":"als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/","title":{"rendered":"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease"},"content":{"rendered":"

UNC Neurology’s Todd Cohen, PhD and other researchers team up to reverse TDP-43 protein aggregation, a hallmark of degenerative diseases.<\/p>\n

\n
\"image2\"
Todd Cohen, PhD<\/figcaption><\/figure>\n<\/div>\n
\n

July 19, 2017<\/p>\n

CHAPEL HILL, NC \u2013 Scientists have long known that a protein called TDP-43 clumps together in brain cells of people with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig\u2019s Disease, and is associated with neuron death. This same protein is thought to cause muscle degeneration in patients with sporadic inclusion body myositis (sIBM), leading many researchers to think that TDP-43 is one of the causative factors in ALS and sIBM. Now, UNC School of Medicine and NC State researchers found that a specific chemical modification called acetylation promotes TDP-43 clumping in animals. Using a natural anti-clumping method in mouse models, the scientists reversed protein clumping in muscle cells and prevented the sIBM-related muscle weakness.<\/p>\n

The discovery, published in Nature Communications<\/i>, has important implications for understanding ALS and sIBM, and for the creation of potential treatments down the road.<\/p>\n

\u201cWe suspect that getting rid of this abnormal TDP-43 clumping could be a potential therapy for these diseases,\u201d said study senior author Todd J. Cohen, PhD, assistant professor of neurology at UNC. \u201cIn principle, we think this reversal of clumping could be achieved by taking an injectable or oral medication. Though, we caution, that\u2019s still a long way off. The research community still has much more work to do.\u201d<\/p>\n

Red muscle fibers with TDP-43 clumping in green. (Courtesy of the Cohen Lab.)TDP-43 normally works in the cell nucleus. It binds to DNA and to the RNA molecules transcribed from DNA. The protein appears to have many important functions in regulating how genes are expressed. Somehow \u2013 in people with sIBM, ALS, and a few other degenerative diseases \u2013 TDP-43 moves out of the nucleus and into the main volume of the cell, or cytoplasm, and then clumps together. The loss of TDP-43 from the nucleus leads to the failure of normal gene expression regulation. Many scientists suspect that this is the major reason why affected cells die. In ALS, motor neuron death leads to the brain\u2019s inability to control voluntary muscles throughout the body. In sIBM, muscle degeneration leads to muscle weakness and impaired strength.<\/p>\n

For many years, no one knew how TDP-43 moved out of its normal workspace in the cell nucleus. In a 2015 study<\/a>, Cohen and colleagues found one possible factor: a chemical modification known as acetylation.<\/p>\n

Cells commonly use acetylation to switch the activity of proteins on or off. In 2015, Cohen and colleagues reported that acetylation at two spots on TDP-43 caused the protein to detach from RNA. The protein then drifted into the cytoplasm and started to aggregate. This research was done in cells grown in lab dishes. But to underscore the potential relevance to human disease, the scientists examined spinal motor neurons from ALS patients and identified aggregates of TDP-43 that had been acetylated in the same way.<\/p>\n

\u201cIt could be that acetylation of TDP-43 normally functions as a \u2018switch\u2019 that controls TDP-43\u2019s ability to bind to its targets \u2013 DNA and RNA,\u201d said Cohen, a member of the UNC Neuroscience Center. If so, how that normal switching process goes awry in ALS and other TDP-43 diseases is still undetermined.<\/p>\n

For the new study, the researchers examined the effect of acetylated TDP-43 in living animals. In this case, they sought to mimic sIBM in mice, in which TDP-43 clumps in muscle cells.<\/p>\n

Michael Bereman, PhD, an author on the paper and assistant professor at NC State University, uses mass spectrometry to study modifications to proteins.<\/p>\n

Michael Bereman, PhD, NC State researcher\u201cIt\u2019s pretty amazing that a modification that represents 0.1 percent of the protein mass can have such a detrimental effect in essentially initiating the processes culminating in cell death,\u201d said Bereman, a member of the Center for Human Health and the Environment at NC State. \u201cBut that just emphasizes how complex disease biology can be. It\u2019s quite possible that other modifications to this protein could act in a similar manner. So it\u2019s imperative we investigate this with new technologies in sample preparation and mass spectrometry.\u201d<\/p>\n

\u201cI tend to see sIBM and ALS as resulting from essentially the same TDP-43-related pathological process \u2013 the clumping effect \u2013 but in different cell types,\u201d Cohen said. \u201cThe advantage of studying sIBM is that muscle cells are much more accessible than are motor neurons, which are affected in ALS.\u201d Once we understand the role of TDP-43 in sIBM, we can also study this process in neurons.<\/p>\n

He and his team used a special method to inject acetylated TDP-43 proteins directly into mouse muscle cells. In contrast to ordinary TDP-43 proteins, these acetylated proteins quickly aggregated outside the nucleus. The aggregate-burdened cells showed multiple features that are also seen in human sIBM.<\/p>\n

The researchers observed cellular markers indicating that the muscle cells were actively trying to get rid of the TDP-43 aggregates. Cohen and his team found that they could boost these cell defense mechanisms and swiftly remove most of the aggregates by adding heat shock factor 1 (HSF1), a naturally occurring protein that is known to work as a master switch for anti-aggregation processes in cells.<\/p>\n

Cohen\u2019s team now hopes to identify compounds suitable for use in oral drugs that have the same anti-clumping effect. Bereman hopes to develop targeted protein assays of acetylated and ubiquitinated forms of TDP-43 to aid Cohen\u2019s drug screening efforts as a measure of drug effectiveness.<\/p>\n

\u201cIdeally we would give someone with sIBM a drug that boosts these anti-aggregation systems, and the result would be the removal of the TDP-43 aggregates and the eventual recovery of muscle function,\u201d Cohen said. \u201cWe hope and suspect that a similar approach would work for neurons in ALS, too.\u201d<\/p>\n

The lead author of the study was UNC postdoctoral researcher Ping Wang, PhD. Other co-authors were UNC graduate student Connor M. Wander, and Chao-Xing Yuan, PhD, of the University of Pennsylvania.<\/i><\/p>\n

The National Institutes of Health funded this work.<\/i><\/p>\n

Media Contact: Mark Derewicz, 919-923-0959, mark.derewicz@unchealth.unc.edu<\/a><\/i><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

<\/p>\n

UNC Neurology’s Todd Cohen, PhD and other researchers team up to reverse TDP-43 protein aggregation, a hallmark of degenerative diseases.<\/p>\n","protected":false},"author":58435,"featured_media":3010,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[3],"class_list":["post-3009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-home-page-news","odd"],"acf":[],"yoast_head":"\nALS: New Clues to the Cause and How Future Drugs Might Reverse Disease | Department of Neurology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease | Department of Neurology\" \/>\n<meta property=\"og:description\" content=\"UNC Neurology's Todd Cohen, PhD and other researchers team up to reverse TDP-43 protein aggregation, a hallmark of degenerative diseases.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Neurology\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UNCNeurology\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-07-26T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-05T18:31:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"537\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Peggy Felix\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNCneurology\" \/>\n<meta name=\"twitter:site\" content=\"@UNCneurology\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Peggy Felix\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\"},\"author\":{\"name\":\"Peggy Felix\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/person\/14c90ff7a3e23f1201695fd9f347c9fd\"},\"headline\":\"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease\",\"datePublished\":\"2017-07-26T22:40:00+00:00\",\"dateModified\":\"2022-12-05T18:31:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\"},\"wordCount\":1022,\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg\",\"keywords\":[\"Home Page News\"],\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\",\"url\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\",\"name\":\"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease | Department of Neurology\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg\",\"datePublished\":\"2017-07-26T22:40:00+00:00\",\"dateModified\":\"2022-12-05T18:31:31+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg\",\"width\":400,\"height\":537,\"caption\":\"Todd Cohen, PhD\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neurology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neurology\/\",\"name\":\"Department of Neurology\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neurology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#organization\",\"name\":\"UNC Department of Neurology\",\"url\":\"https:\/\/www.med.unc.edu\/neurology\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/new_neurology_logo.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/new_neurology_logo.jpg\",\"width\":1657,\"height\":601,\"caption\":\"UNC Department of Neurology\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/UNCNeurology\/\",\"https:\/\/x.com\/UNCneurology\",\"https:\/\/www.instagram.com\/unc_neurology\/\",\"https:\/\/www.linkedin.com\/in\/unc-neurology\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/person\/14c90ff7a3e23f1201695fd9f347c9fd\",\"name\":\"Peggy Felix\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/e918c3efd3be03acc1ec7c6929e8e8708153e7a8a291a69ef96fb5f6f7f563db?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/e918c3efd3be03acc1ec7c6929e8e8708153e7a8a291a69ef96fb5f6f7f563db?s=96&d=mm&r=g\",\"caption\":\"Peggy Felix\"},\"description\":\"Neurosurgery - Admin\",\"url\":\"https:\/\/www.med.unc.edu\/neurology\/author\/pfelix\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease | Department of Neurology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/","og_locale":"en_US","og_type":"article","og_title":"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease | Department of Neurology","og_description":"UNC Neurology's Todd Cohen, PhD and other researchers team up to reverse TDP-43 protein aggregation, a hallmark of degenerative diseases.","og_url":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/","og_site_name":"Department of Neurology","article_publisher":"https:\/\/www.facebook.com\/UNCNeurology\/","article_published_time":"2017-07-26T22:40:00+00:00","article_modified_time":"2022-12-05T18:31:31+00:00","og_image":[{"width":400,"height":537,"url":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","type":"image\/jpeg"}],"author":"Peggy Felix","twitter_card":"summary_large_image","twitter_creator":"@UNCneurology","twitter_site":"@UNCneurology","twitter_misc":{"Written by":"Peggy Felix","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/"},"author":{"name":"Peggy Felix","@id":"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/person\/14c90ff7a3e23f1201695fd9f347c9fd"},"headline":"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease","datePublished":"2017-07-26T22:40:00+00:00","dateModified":"2022-12-05T18:31:31+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/"},"wordCount":1022,"publisher":{"@id":"https:\/\/www.med.unc.edu\/neurology\/#organization"},"image":{"@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","keywords":["Home Page News"],"articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/","url":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/","name":"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease | Department of Neurology","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neurology\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","datePublished":"2017-07-26T22:40:00+00:00","dateModified":"2022-12-05T18:31:31+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#primaryimage","url":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","width":400,"height":537,"caption":"Todd Cohen, PhD"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neurology\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neurology\/"},{"@type":"ListItem","position":2,"name":"ALS: New Clues to the Cause and How Future Drugs Might Reverse Disease"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neurology\/#website","url":"https:\/\/www.med.unc.edu\/neurology\/","name":"Department of Neurology","description":"","publisher":{"@id":"https:\/\/www.med.unc.edu\/neurology\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neurology\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.med.unc.edu\/neurology\/#organization","name":"UNC Department of Neurology","url":"https:\/\/www.med.unc.edu\/neurology\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/logo\/image\/","url":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/new_neurology_logo.jpg","contentUrl":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/new_neurology_logo.jpg","width":1657,"height":601,"caption":"UNC Department of Neurology"},"image":{"@id":"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/UNCNeurology\/","https:\/\/x.com\/UNCneurology","https:\/\/www.instagram.com\/unc_neurology\/","https:\/\/www.linkedin.com\/in\/unc-neurology\/"]},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/person\/14c90ff7a3e23f1201695fd9f347c9fd","name":"Peggy Felix","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neurology\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/e918c3efd3be03acc1ec7c6929e8e8708153e7a8a291a69ef96fb5f6f7f563db?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e918c3efd3be03acc1ec7c6929e8e8708153e7a8a291a69ef96fb5f6f7f563db?s=96&d=mm&r=g","caption":"Peggy Felix"},"description":"Neurosurgery - Admin","url":"https:\/\/www.med.unc.edu\/neurology\/author\/pfelix\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","featured_image_medium":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2-223x300.jpeg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","featured_image_large":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2.jpeg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/neurology\/wp-content\/uploads\/sites\/716\/2018\/05\/als-new-clues-to-the-cause-and-how-future-drugs-might-reverse-disease-image2-150x201.jpeg","featured_image_alt":"Todd Cohen, PhD","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/neurology\/category\/news\/"}],"tag_details":[{"name":"Home Page News","link":"https:\/\/www.med.unc.edu\/neurology\/tag\/home-page-news\/"}],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/posts\/3009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/users\/58435"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/comments?post=3009"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/posts\/3009\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/media\/3010"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/media?parent=3009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/categories?post=3009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/neurology\/wp-json\/wp\/v2\/tags?post=3009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}