{"id":4694,"date":"2015-09-01T13:41:00","date_gmt":"2015-09-01T17:41:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/directory\/wyatt\/"},"modified":"2018-07-26T13:12:36","modified_gmt":"2018-07-26T17:12:36","slug":"wyatt","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/directory\/wyatt\/","title":{"rendered":"Elliott Wyatt"},"content":{"rendered":"<div>\n<h3><span style=\"color: #000000;\">About<\/span><\/h3>\n<p><span style=\"color: #000000;\">Elliott completed his B.S. degree in Molecular and Structural Biochemistry from North Carolina State University in 2013. Following graduation, he accepted a 2-year NIH fellowship at Rocky Mountain Laboratories in Montana, where he worked under the supervision of Catharine Bosio to investigate how the pathogenic bacterium <i>Francisella tularensis<\/i><\/span><span style=\"color: #000000;\"> avoids detection by the immune system by reprogramming the host\u2019s cellular metabolism. Elliott is currently a member of Dr. Patricia Maness\u2019s lab, where he studies the role of semaphoring signaling on dendritic spine remodeling during brain development. In his free time, he enjoys hiking, biking, craft beer, and going to concerts. <\/span><\/p>\n<h3><span style=\"color: #000000;\"><span style=\"color: #000000;\"> Research<\/span><\/span><\/h3>\n<p style=\"margin: 0in 0in 8pt;\"><span style=\"color: #000000;\">During development of the brain, traveling axons are forming and breaking temporary connections with recipient dendrites, until their final destination has been reached. The Maness lab is focused on understanding the role of guidance cues (L1CAMs, semaphorins, ephrins) in the formation and maturation of proper synapses during development. Specifically, Elliott is interested in how the aversive molecule Semaphorin 3F interacts with the L1CAM family member NrCAM on an immature dendritic spine and signals to the cytoskeleton for retraction \u2013 effectively breaking the connection and allowing the axon to continue migration. Defects in this plasticity process can lead to an over-accumulation of synaptic connections, which disrupts the overall E\/I balance and has been linked to the manifestation of autism spectrum disorder.<\/span><\/p>\n<p class=\" \" style=\"margin: 0in 0in 0pt;\"><b><span style=\"color: #000000;\"><span style=\"color: #000000;\"><span class=\"largeFont\">Activities\/Awards<br \/>\n<\/span><br \/>\n<\/span><\/span><\/b><\/p>\n<p style=\"margin: 0in 0in 8pt;\"><span style=\"color: #000000;\">T32 Neuroscience Training Grant (2017-Present)<br \/>\n<\/span><span style=\"color: #000000;\">NIH Intramural Research Training Award (2014-2016)<\/span><\/p>\n<h3><span style=\"color: #000000;\">\u00a0<\/span><\/h3>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>About Elliott completed his B.S. degree in Molecular and Structural Biochemistry from North Carolina State University in 2013. Following graduation, he accepted a 2-year NIH fellowship at Rocky Mountain Laboratories in Montana, where he worked under the supervision of Catharine Bosio to investigate how the pathogenic bacterium Francisella tularensis avoids detection by the immune system &hellip; <a href=\"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/directory\/wyatt\/\" aria-label=\"Read more about Elliott Wyatt\">Read more<\/a><\/p>\n","protected":false},"featured_media":4483,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-4694","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Elliott Wyatt"],"_upd_reverse_display_name":["Wyatt, Elliott"],"_upd_last_name":["Wyatt"],"_upd_first_name":["Elliott"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Lab Name<\/strong>: Maness\r\n<span style=\"line-height: 1.43em\"><strong>Lab Room #<\/strong>: 3020 GMB\r\n<\/span><span style=\"line-height: 1.43em\"><strong>Lab Phone #<\/strong>:\u00a0919-966-3532 <\/span>\r\n<strong>Email<\/strong>:\u00a0<a href=\"mailto:evwyatt@email.unc.edu\">evwyatt@email.unc.edu<\/a>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[],"_upd_phone":[],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/wp-json\/wp\/v2\/directory\/4694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/wp-json\/wp\/v2\/directory\/4694\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/wp-json\/wp\/v2\/media\/4483"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/curriculum\/wp-json\/wp\/v2\/media?parent=4694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}