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Large Aggregates of ALS-causing Protein Might Actually Help Brain Cells
The Dokholyan and Deshmukh labs published a report in PNAS where they examined the neurotoxicity of various SOD1 protein aggregates in a model of Amyotrophic Lateral Sclerosis (ALS). The large SOD1 aggregates, which are a hallmark of ALS, are generally considered to contribute to motor neuron death in ALS. However, the study found that the large SOD1 aggregates are less toxic than the smaller SOD1 trimers. These results suggest that therapies targeted towards the SOD1 trimers, rather than the larger SOD1 fibrils, may be more effective for the treatment of ALS. Apr 23, 2018
Nagendran Muthusamy, PhD, Wins 2018 Robert & Margaret Grossfeld Award
Matsushima Lab Research Scientist, Nagendran Muthusamy, is the 2018 Robert and Margaret Grossfeld Award Recipient. This award recognizes his outstanding 2017 publication in Nature Neuroscience. Apr 16, 2018
Bryan Roth, MD, PhD, to give Presidential Special Lecture at 2018 SFN Meeting
UNC investigator, Bryan Roth, will give a Presidential Special Lecture entitled "From Salvia Divinorum to LSD—Toward a Molecular Understanding of Psychoactive Drug Actions" at the 2018 meeting of the Society for Neuroscience. Apr 16, 2018
Graham Diering, PhD, Publishes in PNAS
Memories can last a lifetime, but the neuronal synapses that store memories are made of macrolmolecules such as proteins that undergo synthesis and degradation on the scale of hour to days. The Huganir Lab, in which Dieiring was recently a postdoctoral scholar, hypothesized that a population of extremely long-lived proteins may reside at synapses, forming part of the substrate for long-term storage of memories. Here they have used metabolic labeling of mice and cultured neurons, combined with mass spectrometry to identify the synaptic long-lived proteome. Apr 03, 2018
Song Lab Publishes Cover Article of Stem Cell Reports
The latest publication from the Song Lab, "An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus", has made the cover of Stem Cell Reports! Mar 13, 2018