{"id":4375,"date":"2018-07-09T10:54:31","date_gmt":"2018-07-09T14:54:31","guid":{"rendered":"https:\/\/www.med.unc.edu\/neuroscience\/?post_type=directory&#038;p=4375"},"modified":"2021-04-28T12:56:00","modified_gmt":"2021-04-28T16:56:00","slug":"jay-brenman-phd","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/","title":{"rendered":"Jay Brenman, PhD"},"content":{"rendered":"<h2>Research Description<\/h2>\n<p>All cells and organisms must monitor and maintain their energy levels for survival. One particular protein kinase, AMP-activated protein kinase (AMPK) plays a central role in energy balance. AMPK consists of a protein complex encoded by three subunits, a serine-threonine kinase catalytic subunit (\u03b1) and two regulatory subunits (\u00df, \u03b3). When AMPK signaling is disrupted cells undergo cell death and organisms can not survive limited starvation.<\/p>\n<p>AMPK has many potential biomedically-relevant functions. AMPK is proposed to be a therapeutic target for Type 2 diabetes and Metabolic syndrome (obesity, insulin resistance, cardiovascular disease). In addition, since cancer cells have larger energetic requirements than non-dividing cells, targeting AMPK might be an attractive approach for attacking cancer.<\/p>\n<p>We identified mutations in the AMPK kinase domain (AMPK\u03b1) during a genetic screen looking for &#8220;neurodegeneration mutants&#8221; in Drosophila. Inactivation of AMPK leads to neurodegeneration-like phenotypes in neurons and abnormal metabolism in other cells. Our lab uses combinations of genetics, biochemistry\/proteomics and cell culture models to try to further identify new molecules involved in AMPK signaling. We are particularly interested in how AMPK signaling and molecules it regulates are relevant to:<\/p>\n<ul>\n<li>Neurodegeneration<\/li>\n<li>Metabolism (Type 2 Diabetes\/Cardiac Disease)<\/li>\n<li>Cancer<\/li>\n<\/ul>\n<p>I am the Director of Graduate Studies for the Neuroscience PhD Curriculum and the Cell Biology and Physiology Curriculum.<\/p>\n<p><a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/browse\/collection\/41147416\/?sort=date&amp;direction=descending\" target=\"_self\" rel=\"noopener noreferrer\">Publications<\/a><\/p>\n<hr \/>\n<h2>Affiliations<\/h2>\n<ul>\n<li><a class=\"external-link\" href=\"http:\/\/www.med.unc.edu\/cellbiophysio\/faculty\/brenman\">Cell Biology and Physiology<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Research Description All cells and organisms must monitor and maintain their energy levels for survival. One particular protein kinase, AMP-activated protein kinase (AMPK) plays a central role in energy balance. AMPK consists of a protein complex encoded by three subunits, a serine-threonine kinase catalytic subunit (\u03b1) and two regulatory subunits (\u00df, \u03b3). When AMPK signaling &hellip; <a href=\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/\" aria-label=\"Read more about Jay Brenman, PhD\">Read more<\/a><\/p>\n","protected":false},"featured_media":2638,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-4375","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jay Brenman, PhD | UNC Neuroscience Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jay Brenman, PhD | UNC Neuroscience Center\" \/>\n<meta property=\"og:description\" content=\"Research Description All cells and organisms must monitor and maintain their energy levels for survival. One particular protein kinase, AMP-activated protein kinase (AMPK) plays a central role in energy balance. AMPK consists of a protein complex encoded by three subunits, a serine-threonine kinase catalytic subunit (\u03b1) and two regulatory subunits (\u00df, \u03b3). When AMPK signaling &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/\" \/>\n<meta property=\"og:site_name\" content=\"UNC Neuroscience Center\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-28T16:56:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"130\" \/>\n\t<meta property=\"og:image:height\" content=\"164\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@uncneuro\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/\",\"name\":\"Jay Brenman, PhD | UNC Neuroscience Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg\",\"datePublished\":\"2018-07-09T14:54:31+00:00\",\"dateModified\":\"2021-04-28T16:56:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg\",\"width\":130,\"height\":164},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/neuroscience\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Jay Brenman, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/neuroscience\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/neuroscience\/\",\"name\":\"UNC Neuroscience Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Jay Brenman, PhD | UNC Neuroscience Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/","og_locale":"en_US","og_type":"article","og_title":"Jay Brenman, PhD | UNC Neuroscience Center","og_description":"Research Description All cells and organisms must monitor and maintain their energy levels for survival. One particular protein kinase, AMP-activated protein kinase (AMPK) plays a central role in energy balance. AMPK consists of a protein complex encoded by three subunits, a serine-threonine kinase catalytic subunit (\u03b1) and two regulatory subunits (\u00df, \u03b3). When AMPK signaling &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/","og_site_name":"UNC Neuroscience Center","article_modified_time":"2021-04-28T16:56:00+00:00","og_image":[{"width":130,"height":164,"url":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_site":"@uncneuro","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/","url":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/","name":"Jay Brenman, PhD | UNC Neuroscience Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg","datePublished":"2018-07-09T14:54:31+00:00","dateModified":"2021-04-28T16:56:00+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#primaryimage","url":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg","contentUrl":"https:\/\/www.med.unc.edu\/neuroscience\/wp-content\/uploads\/sites\/782\/2018\/07\/jay-brenman.jpeg","width":130,"height":164},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/neuroscience\/directory\/jay-brenman-phd\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/neuroscience\/"},{"@type":"ListItem","position":2,"name":"Jay Brenman, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/neuroscience\/#website","url":"https:\/\/www.med.unc.edu\/neuroscience\/","name":"UNC Neuroscience Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/neuroscience\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_upd_display_name":["Jay Brenman, PhD"],"_upd_reverse_display_name":["Brenman, Jay"],"_upd_last_name":["Brenman"],"_upd_first_name":["Jay"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Professor<\/strong>\r\nOffice: 5206C MEJ\r\nPhone: (919) 843-3637\r\n<a class=\"external-link\" title=\"\" href=\"https:\/\/www.med.unc.edu\/cellbiophysio\/people\/primary-faculty\/jay-brenman-phd\" target=\"_blank\" rel=\"noopener\">Bio<\/a>\u00a0|\u00a0<span class=\"mail-link\"><a class=\"mail-link\" href=\"mailto:jay_brenman@med.unc.edu\">Email<\/a><\/span>"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"brenman@med.unc.edu"}]],"_upd_phone":[[{"phone_text":"(919) 843-3637","phone_type":"Office Phone"}]],"_upd_address":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/directory\/4375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/directory\/4375\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media\/2638"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/neuroscience\/wp-json\/wp\/v2\/media?parent=4375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}